Clinical Epigenetics,
Год журнала:
2024,
Номер
16(1)
Опубликована: Ноя. 19, 2024
In
recent
years,
epigenetic
modifications
have
been
strongly
linked
to
tumor
development,
with
histone
representing
a
key
mechanism.
addition,
non-coding
RNAs
(ncRNAs)
play
critical
role
in
regulating
cancer-related
pathways.
The
abnormal
interaction
between
and
ncRNAs,
both
pivotal
regulators,
has
widely
observed
across
various
cancer
types.
Here,
we
systematically
explore
the
molecular
mechanisms
through
which
ncRNAs
contribute
pathogenesis
of
digestive
system
cancers,
aberrant
ncRNA-mediated
manipulate
biological
behaviors
cells
including
proliferation,
migration,
angiogenesis,
etc.
provide
new
insights
into
diagnostic,
prognostic
markers,
therapeutic
targets
chemoradiation
resistance
for
cancers
from
perspective.
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 30, 2025
Lactate,
the
end
product
of
glycolysis,
plays
a
crucial
role
in
cellular
signaling
and
metabolism.
The
discovery
lactylation,
novel
post-translational
modification,
has
uncovered
lactate
regulating
diseases,
especially
brain.
Lactylation
connects
genetic
encoding
with
protein
function,
thereby
influencing
key
biological
processes.
Increasing
evidence
supports
lactate-mediated
lactylation
as
critical
modulator
neurological
disorders.
This
review
offers
an
overview
metabolism
highlighting
recent
advances
understanding
regulatory
enzymes
their
central
nervous
system.
We
investigate
impact
on
brain
dysfunctions,
including
neurodegenerative
cerebrovascular
disorders,
neuroinflammation,
tumors,
psychiatric
conditions.
Moreover,
we
highlight
therapeutic
potential
targeting
treating
disorders
outline
research
gaps
future
directions
needed
to
advance
this
promising
field.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13614 - 13614
Опубликована: Дек. 19, 2024
Neuroimmunology
is
reshaping
the
understanding
of
central
nervous
system
(CNS),
revealing
it
as
an
active
immune
organ
rather
than
isolated
structure.
This
review
delves
into
unprecedented
discoveries
transforming
field,
including
emerging
roles
microglia,
astrocytes,
and
blood–brain
barrier
(BBB)
in
orchestrating
neuroimmune
dynamics.
Highlighting
their
dual
both
repair
disease
progression,
we
uncover
how
these
elements
contribute
to
intricate
pathophysiology
neurodegenerative
diseases,
cerebrovascular
conditions,
CNS
tumors.
Novel
insights
microglial
priming,
astrocytic
cytokine
networks,
meningeal
lymphatics
challenge
conventional
paradigms
privilege,
offering
fresh
perspectives
on
mechanisms.
work
introduces
groundbreaking
therapeutic
innovations,
from
precision
immunotherapies
controlled
modulation
BBB
using
nanotechnology
focused
ultrasound.
Moreover,
explore
fusion
with
neuromodulatory
technologies,
underscoring
new
frontiers
for
personalized
medicine
previously
intractable
diseases.
By
synthesizing
advancements,
propose
a
transformative
framework
that
integrates
cutting-edge
research
clinical
translation,
charting
bold
path
toward
redefining
management
era
neuroimmunology.
ACS Chemical Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 24, 2024
Epigenetic
modifications
play
a
pivotal
role
in
the
process
of
neurogenesis.
Among
these
modifications,
reversible
acetylation
fine-tunes
gene
expression
for
both
embryonic
and
adult
The
CBP/KAT3A
its
paralogue
p300/KAT3B
are
well-known
lysine
acetyltransferases
with
transcriptional
coactivation
ability
that
engage
neural
plasticity
memory.
exclusive
their
KAT
activity
neurogenesis
memory
could
not
be
addressed
due
to
absence
p300/CBP
modulator,
which
can
cross
blood-brain
barrier.
Previous
work
from
our
laboratory
has
shown
small
molecule
activator,
TTK21,
specific
CBP/p300,
when
conjugated
glucose-derived
carbon
nanospheres
(CSP),
is
efficiently
delivered
mouse
brain
induce
dendritic
branching
extend
long-term
However,
molecular
mechanisms
p300
acetyltransferase
activity-dependent
enhanced
dendritogenesis
yet
understood.
Here,
we
report
CSP-TTK21
treatment
primary
neuronal
culture
derived
embryo
enhances
five
critical
genes:
Clinical Epigenetics,
Год журнала:
2024,
Номер
16(1)
Опубликована: Ноя. 19, 2024
In
recent
years,
epigenetic
modifications
have
been
strongly
linked
to
tumor
development,
with
histone
representing
a
key
mechanism.
addition,
non-coding
RNAs
(ncRNAs)
play
critical
role
in
regulating
cancer-related
pathways.
The
abnormal
interaction
between
and
ncRNAs,
both
pivotal
regulators,
has
widely
observed
across
various
cancer
types.
Here,
we
systematically
explore
the
molecular
mechanisms
through
which
ncRNAs
contribute
pathogenesis
of
digestive
system
cancers,
aberrant
ncRNA-mediated
manipulate
biological
behaviors
cells
including
proliferation,
migration,
angiogenesis,
etc.
provide
new
insights
into
diagnostic,
prognostic
markers,
therapeutic
targets
chemoradiation
resistance
for
cancers
from
perspective.
