Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target DOI Creative Commons

Qian-Yun Ye,

Yan Cui, Haoyu Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Bone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of can lead to the development metabolic diseases such as osteoporosis osteoarthritis. The maintenance is a complex process that does not solely rely on functions tissue itself. In fact, an isolated entity; it closely connected other tissues in body via exosomes. Within this interconnectivity, exosomes derived from both non-bone cells interfere with each other, forming regulatory network. Therefore, cell origin guiding principle, we have delineated network exosomes, elaborated specific roles mechanisms common types (cells within skeletal microenvironment, stem extra-osseous tissues, vascular-derived cells, muscle-derived neurogenic cells) formation, resorption, We also discussed challenges faced field exosome research related homeostasis, unveiled critical role maintaining proposed could serve highly valuable therapeutic targets for diseases.

Язык: Английский

Nrf2 Activation as a Therapeutic Target for Flavonoids in Aging-Related Osteoporosis DOI Open Access

Samia S. Messeha,

Fidara F. Fidudusola,

Sherif Gendy

и другие.

Nutrients, Год журнала: 2025, Номер 17(2), С. 267 - 267

Опубликована: Янв. 13, 2025

Biological aging is a substantial change that leads to different diseases, including osteoporosis (OP), condition involved in loss of bone density, deterioration structure, and increased fracture risk. In old people, there natural decline mineral density (BMD), exacerbated by hormonal changes, particularly during menopause, it continues the early postmenopausal years. During this transition time, alterations are linked elevated oxidative stress (OS) decreased antioxidant defenses, leading significant increase OP. Aging significantly associated with an abnormal ratio oxidant/antioxidant modified nuclear factor erythroid-derived two related factor2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway. OS adversely affects health promoting osteoclastic (bone resorbing) activity impairing osteoblastic (bone-forming cells). Nrf2 critical controlling various cellular processes. The expression multiple age-related OP, deficiency unbalanced formation/resorption consequent mass. Various drugs available for treating OP; however, long-term uses these medicines implicated diverse illnesses such as cancer, cardiovascular, stroke. At same categories products, particular flavonoids, were proposed safe alternatives anti-osteoporotic effects.

Язык: Английский

Процитировано

1
Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases DOI Creative Commons
Hong Li, Peng Zhang, Minghui Lin

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 12, 2025

Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types offer strong regenerative potential, making them promising for treating various diseases. However, issues with immune response survival limit effectiveness transplantation. This has led increased interest in cell-free therapy, particularly use exosomes, which is most studied form this approach. Exosomes are extracellular vesicles that contain proteins, lipids, nucleic acids play key role communication material exchange. Pyroptosis, death involved innate immunity, also associated many Studies have shown MSC-derived exosomes therapeutic potential range conditions by regulating inflammation pyroptosis. study explored modulating pyroptosis improve bone-related

Язык: Английский

Процитировано

1
Deciphering the skeletal interoceptive circuitry to control bone homeostasis DOI Creative Commons

Yefeng Wu,

Jiusi Guo, Zhen Chen

и другие.

BMEMat, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Bone tissue is richly innervated, and the influence of nervous system on physiological pathological status bone has emerged as a significant research focus. The recent discovery skeletal interoceptive circuits further emphasizes crucial role central in control homeostasis. Skeletal interoception represents one most intricate mechanisms human body for maintaining homeostasis, it involves orchestrated efforts skeletal, nervous, immune, endocrine systems. In this review, we comprehensively introduce three primary components circuitry, including ascending pathways that perceive convey signals to system, neural process interpret these signals, descending mediate regulatory effects tissue. We also discuss how innovative therapeutic strategies can be developed modulate homeostasis by leveraging updated findings circuitry. anticipate application knowledge will lead paradigm shift field orthopaedics biomaterials.

Язык: Английский

Процитировано

0
Schwann cell-derived exosomes accelerate periodontal bone regeneration with osteogenesis, angiogenesis, and neurogenesis DOI

Ya Feng Cui,

Xiaojing Li,

Xiaoya He

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Severe periodontitis frequently leads to irreversible degradation of alveolar bone. Periodontal regeneration techniques hold immense potential in reconstructing bone post periodontal diseases. Schwann cells (SCs) play a critical role supporting, maintaining, and regenerating tissues, with SC-derived exosomes (SC-EXO) exhibiting cell homing tissue repair capabilities. Nevertheless, the specific SC-EXO remains unknown. To address issue, we treated human ligament (hPDLCs) observed notable increase proliferation, osteogenic neurogenic differentiation. Moreover, stimulated expression angiogenic factors vascular endothelial cells. In rat model defects, facilitated recruitment endogenous cells, regulated neural neogenesis, accelerated regeneration. This study successfully prepared SC-EXO, which effectively promotes by regulating healing microenvironment, potentially offering valuable strategy for engineering.

Язык: Английский

Процитировано

0
Tavns Enhances Hippocampal Il10 to Aid Fracture Healing Via Nfatc1/Rankl Pathway Combined Ai Functional Evaluation DOI
Huifang Zhao, Yang Zhang, Yingnan Li

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Cerebrospinal fluid metabolites reveal the potential pathogenesis of osteoporosis DOI Creative Commons

Chuanglong Xu,

Hongyu Wang,

Chunlan Tang

и другие.

Asian Journal of Surgery, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target DOI Creative Commons

Qian-Yun Ye,

Yan Cui, Haoyu Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Bone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of can lead to the development metabolic diseases such as osteoporosis osteoarthritis. The maintenance is a complex process that does not solely rely on functions tissue itself. In fact, an isolated entity; it closely connected other tissues in body via exosomes. Within this interconnectivity, exosomes derived from both non-bone cells interfere with each other, forming regulatory network. Therefore, cell origin guiding principle, we have delineated network exosomes, elaborated specific roles mechanisms common types (cells within skeletal microenvironment, stem extra-osseous tissues, vascular-derived cells, muscle-derived neurogenic cells) formation, resorption, We also discussed challenges faced field exosome research related homeostasis, unveiled critical role maintaining proposed could serve highly valuable therapeutic targets for diseases.

Язык: Английский

Процитировано

0