Extracellular vesicles in Helicobacter pylori-mediated diseases: mechanisms and therapeutic potential
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 11, 2025
Extracellular
vesicles
(EVs)
are
relevant
elements
for
cell-to-cell
communication
and
considered
crucial
in
host-pathogen
interactions
by
transferring
molecules
between
the
pathogen
host
during
infections.
These
structures
participate
various
physiological
pathological
processes
promising
candidates
as
disease
markers,
therapeutic
reagents,
drug
carriers.
Both
H.
pylori
epithelial
cells
infected
secrete
EVs,
which
contribute
to
inflammation
development
of
phenotypes.
However,
many
aspects
cellular
molecular
biology
EV
functions
remain
incompletely
understood
due
methodological
challenges
studying
these
small
structures.
This
review
also
highlights
roles
EVs
derived
from
pylori-infected
pathogenesis
gastric
extragastric
diseases.
Understanding
specific
infections,
whether
advantageous
or
pathogen,
may
help
new
approaches
prevent
disease.
Язык: Английский
Microglia and Gut Microbiota: A Double-Edged Sword in Alzheimer's Disease
Ageing Research Reviews,
Год журнала:
2024,
Номер
unknown, С. 102515 - 102515
Опубликована: Сен. 1, 2024
Язык: Английский
Polymicrobial interactions of Helicobacter pylori and its role in the process of oral diseases
Journal of Oral Microbiology,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 25, 2025
Objective
Helicobacter
pylori
(H.
pylori)
infection
affects
approximately
50%
of
the
global
population.
The
predominant
route
H.
transmission
is
through
oral
pathway,
making
cavity
highly
significant
in
its
infection.
This
review
focuses
on
relationship
between
and
diseases,
influence
microbiota,
potential
mechanisms
involving
certain
pathogens.
Язык: Английский
Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study
BMC Gastroenterology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 21, 2025
Current
evidence
on
the
associations
between
insulin
resistance
(IR)
and
Helicobacter
pylori
(H.
pylori)
infection
remains
limited.
This
study
aimed
to
investigate
association
non-insulin-based
surrogate
markers
of
IR,
including
triglyceride
glucose
(TyG)
index,
high-density
lipoprotein
cholesterol
(TG/HDL-C)
ratio,
metabolic
score
for
IR
(METS-IR),
H.
in
U.S.
populations.
cross-sectional
involving
939
participants
from
National
Health
Nutrition
Examination
Survey
(NHANES)
1999–2000.
The
three
were
respectively
investigated
using
logistic
regression
model,
restricted
cubic
spline
(RCS)
curve
subgroup
analysis.
Three
levels
significantly
elevated
participants.
There
was
a
positive
infection,
even
after
adjusting
potential
confounding
variables
by
different
models.
In
analysis,
adjusted
more
likely
be
observed
female
Non-Hispanic
White.
Additionally,
RCS
revealed
linear
correlation
TyG
index
across
all
models,
METS-IR
Model
3.
However,
nonlinear
TG/HDL-C
ratio
These
findings
suggest
that
positively
associated
with
infection.
may
serve
as
indicators
identifying
risk
Not
applicable.
Язык: Английский
Association of helicobacter pylori infection with coronary artery disease and the severity of angiographic lesions
Cerasus journal of medicine.,
Год журнала:
2025,
Номер
2(1), С. 38 - 48
Опубликована: Фев. 15, 2025
Objective:
There
are
controversies
evaluating
the
association
between
different
strains
of
Helicobacter
pylori
(HP)
and
occurrence
coronary
arterial
disease
(CAD).
HP
may
facilitate
gastric
ulcers
gastrointestinal
bleeding.
As
angiographic
lesions
high
thrombus
burden
needs
more
potent
risky
antithrombotic
treatment
regimens,
we
aimed
to
investigate
role
for
with
burden.
Methods:
Medical
drug
history
109
consecutive
patients
who
were
candidate
angiography
taken.
Blood
samples
obtained
measure
anti
(Ig)
immunoglobulin
G
anti-CagA
(cytotoxin-associated
gene)
IgG
antibody.
According
reports,
participants
divided
into
three
groups.
Normal
(n
=
34),
no
(n=38)
37).
To
CagA
positive
less
virulan
severity
CAD,
ordinal
logistic
regression
tests
used
by
adjusting
age,
sex,
hypertention,
diabetes
mellitus
,
dyslipidemia
smoking.
Results:
The
mean
ages
without
CAD
59±14.
prevalence
seropositivity
titer
was
69%
(n=75).
Fifty
nine
(79%)
subject
had
seropositivity.
Positive
serology
67%
(n=50)
44%
(n=15)
in
control
groups
respectively.
While
wasn’t
associated
lesion
severity;
independently
(OR:
2.4
(1.1-5.6)
p=0.03).
Conclusion:
Colonization
an
independent
risk
factor
severity..
Язык: Английский
The Legalome: Microbiology, Omics and Criminal Justice
Microbial Biotechnology,
Год журнала:
2025,
Номер
18(3)
Опубликована: Март 1, 2025
ABSTRACT
Advances
in
neuromicrobiology
and
related
omics
technologies
have
reinforced
the
idea
that
unseen
microbes
play
critical
roles
human
cognition
behaviour.
Included
this
research
is
evidence
indicating
gut
microbes,
through
direct
indirect
pathways,
can
influence
aggression,
anger,
irritability
antisocial
Moreover,
manufacture
chemicals
are
known
to
compromise
cognition.
For
example,
recent
court
decisions
United
States
Europe
acknowledge
produce
high
levels
of
ethanol,
without
consumption
alcohol
by
defendants.
The
dismissal
driving
while
intoxicated
charges
these
cases—so‐called
auto‐brewery
syndrome—highlights
way
which
microbiome
knowledge
will
enhance
precision,
objectivity
fairness
our
legal
systems.
Here
opinion
essay,
we
introduce
concept
‘legalome’—the
application
science
forensic
psychiatry
criminal
law.
We
argue
rapid
pace
microbial
discoveries,
including
those
challenge
ideas
free
moral
responsibility,
necessitate
a
reconsideration
traditional
doctrines
justifications
retributive
punishment.
implications
extend
beyond
courtroom,
challenging
us
reconsider
how
environmental
factors—from
diet
socioeconomic
conditions—might
shape
preventative
rehabilitative
efforts
their
effects
on
microbiome.
Язык: Английский
Identification of Released Bacterial Extracellular Vesicles Containing Lpp20 from Helicobacter pylori
Microorganisms,
Год журнала:
2025,
Номер
13(4), С. 753 - 753
Опубликована: Март 26, 2025
Helicobacter
pylori
is
a
pathogenic
bacterium
that
causes
gastric
and
extragastric
diseases.
We
have
previously
demonstrated
one
of
the
mechanisms
H.
pylori-associated
chronic
immune
thrombocytopenia
involves
complexes
platelets,
protein
Lpp20
an
anti-Lpp20
antibody.
However,
it
remains
unclear
how
enters
body.
hypothesize
bacterial
extracellular
vesicles
(bEVs)
transport
Lpp20.
Thus,
this
study
assessed
in
bEVs
released
from
seven
clinical
isolates,
using
immunoprecipitation
(IP),
immunoblotting
(IB),
surface
plasmon
resonance
imaging
(SPRi),
with
anti-GroEL
(a
marker
bEVs)
antibodies.
were
each
detected
lysates
all
strains.
IP–IB
experiments
containing
produced
by
five
strains
(J99,
SS1,
HPK5,
JSHR3,
JSHR31).
SPRi
antibody
significantly
higher
reflectance
strain
HPK5
than
its
lpp20-disrupted
(p
<
0.01),
indicating
localization
on
bEVs’
surface;
may
also
be
contained
within
bEVs.
The
not
two
(26695
JSHR6)
or
(26695ΔLpp20
HPK5ΔLpp20).
Differences
detection
are
likely
due
to
variations
bEV
production
resulting
diversity.
Язык: Английский
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Helicobacter pylori infection
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 12, 2025
Evidence
on
the
association
between
non-high-density
lipoprotein
cholesterol
to
high-density
ratio
(NHHR)
and
Helicobacter
pylori
(H.
pylori)
infection
remains
limited.
This
study
investigates
this
correlation
based
U.S.
population.
cross-sectional
research
included
data
834
participants
from
National
Health
Nutrition
Examination
Survey
1999-2000.
The
NHHR
H.
was
examined
using
logistic
regression
models,
restricted
cubic
spline
(RCS)
curve
subgroup
analyses.
Individuals
with
exhibited
significantly
higher
value.
A
significant
positive
observed
across
all
three
even
after
adjusting
for
potential
confounders,
a
stronger
noted
in
males,
individuals
under
60
years
of
age,
non-Hispanic
White
participants.
These
findings
suggest
may
act
as
non-invasive
biomarker
detecting
populations.
Язык: Английский
Sleep-promoting mechanism of Lactobacillus plantarum P8 combined with traditional Chinese medicine revealed by network pharmacology, microbiome, metabolome, and transcriptome analyses
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106606 - 106606
Опубликована: Апрель 1, 2025
Язык: Английский
Helicobacter pylori Vaccine: Mechanism of Pathogenesis, Immune Evasion and Analysis of Vaccine Types
Vaccines,
Год журнала:
2025,
Номер
13(5), С. 526 - 526
Опубликована: Май 15, 2025
Helicobacter
pylori
(H.
pylori)
is
a
gram-negative,
spiral-shaped
bacterium
that
colonizes
the
human
gastric
mucosa,
leading
to
various
diseases.
H.
infection
has
become
pressing
public
health
issue
affects
more
than
50%
of
population
worldwide,
almost
40
years
after
its
discovery.
Traditional
treatments,
based
on
use
bismuth-based
triple
and
quadruple
therapies,
are
effective
while
facing
series
problems,
such
as
difficulty
in
patient
compliance,
rise
antibiotic
resistance,
possible
recurrence
infection.
Therefore,
development
an
efficacious
vaccine
against
would
be
extremely
urgent.
This
review
mainly
elaborates
pathogenic
mechanism
immune
evasion
pylori,
well
strategies
adopted
development,
including
whole-cell
vaccines,
subunit
DNA
live
vector
vaccines.
Animal
studies
clinical
trials
demonstrate
vaccines
significantly
reduce
bacterial
load
provide
cellular
immunity
over
some
time.
Multiple
have
clarified
advantages
limitations
each
candidate
vaccine.
Although
provides
benefits
global
burden,
there
still
significant
challenges
developing
safety,
efficacy,
availability.
Overcoming
these
challenges,
along
with
advancement
technology,
can
better
prevent
treat
Язык: Английский