Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Purpose of review This narrative includes the latest clinical and preclinical evidence on fatty acid exposure telomere length, a widely accepted hallmark aging. Recent findings A large body literature focused n-3 (omega-3) polyunsaturated acids (PUFAs). Observational studies reported beneficial associations with length for self-reported consumption PUFA-rich foods; estimated intake PUFAs; PUFAs blood-based biomarkers in most (but not all) involving lipidomics, promising tool field. Benefits were also observed using different mouse models. Regarding other lipids, inconsistent circulating linoleic acid, whereas inverse n-6/n-3 PUFA ratio. Finally, study Mendelian randomization that monounsaturated have positive effect opposite was saturated acids. Summary Evidence supporting might effects maintaining reinforce salutary these dietary fats. Approach considering ratio is discouraged because it sustained incorrect assumption all species from n-6 families are functionally equivalent.

Язык: Английский