Epigenetic clocks and programmatic aging
Ageing Research Reviews,
Год журнала:
2024,
Номер
101, С. 102546 - 102546
Опубликована: Окт. 16, 2024
The
last
decade
has
seen
remarkable
progress
in
the
characterization
of
methylation
clocks
that
can
serve
as
indicators
biological
age
humans
and
many
other
mammalian
species.
While
processes
aging
underlie
these
have
remained
unclear,
several
clues
pointed
to
a
link
developmental
mechanisms.
These
include
presence
vicinity
clock
CpG
sites
genes
specify
development,
including
those
Hox
(homeobox)
polycomb
classes.
Here
we
discuss
how
recent
advances
programmatic
theories
provide
framework
within
which
be
understood
part
process
aging.
This
includes
such
evolve,
mechanisms
cause
aging,
they
give
rise
late-life
disease.
combination
ideas
from
evolutionary
biology,
biogerontology
biology
open
path
new
discipline,
gerontology
(devo-gero).
Drawing
on
properties
clocks,
offer
hypotheses
exemplify
devo-gero
thinking.
We
suggest
controls
trade-off
between
earlier
fidelity
later
plasticity.
also
propose
existence
an
evolutionarily-conserved
sequence
spanning
ontogenesis,
adult
development
both
constrains
determines
evolution
Язык: Английский
Biological constraint, evolutionary spandrels and antagonistic pleiotropy
Ageing Research Reviews,
Год журнала:
2024,
Номер
101, С. 102527 - 102527
Опубликована: Окт. 5, 2024
Язык: Английский
Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin
Aging,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 12, 2025
The
untimely
passing
of
Dr.
Mikhail
"Misha"
Blagosklonny
has
left
a
lasting
void
in
geroscience
and
oncology.
This
review
examines
his
profound
contributions,
focusing
on
pioneering
the
Hyperfunction
Theory
advocacy
for
rapamycin,
an
mTOR
inhibitor,
as
therapeutic
agent
lifespan
extension.
Contrary
to
traditional
damage-centric
models,
rejects
damage
accumulation
primary
driver
aging.
Instead,
it
redefines
aging
quasi-programmed
process
driven
by
persistent,
excessive
activity
growth-promoting
pathways
beyond
their
developmental
roles,
leading
age-related
pathologies.
We
explore
how
Blagosklonny's
insights
predict
rapamycin's
ability
decelerate
modulating
signaling,
supported
empirical
evidence
across
multiple
physiological
systems,
including
immune,
cardiovascular,
cognitive,
oncologic
health.
His
forward-thinking
approach,
advocating
cautious
clinical
use
rapamycin
suggesting
personalized,
preventive,
combination
therapy
strategies,
catalyzed
interest
translational
geroscience.
synthesizes
legacy,
presenting
foundational
pharmacological
intervention
with
potential
managing
decline
extending
healthspan,
underlines
impact
shifting
research
from
theoretical
frameworks
actionable
interventions.
work
remains
enduring
inspiration,
paving
way
toward
treating
modifiable
condition.
Язык: Английский