Development and validation of a risk prediction model for cognitive impairment in breast cancer patients DOI Creative Commons
Xinmiao Zhang, Jingsong Lu,

Zhangyi Ding

и другие.

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 15, 2024

Breast cancer patients often experience cognitive impairment as a complication during treatment, which seriously affects their quality of life. This study aimed to assess the risk factors associated with in breast and construct validate nomogram model predict this population. In study, we used convenience sampling method select 423 who attended Department Surgery at First Hospital Jinzhou Medical University from September 2023 March 2024. We analyzed these patients' through LASSO regression logistic analysis develop predictive model. The was evaluated using area under curve (AUC) receiver operating characteristic (ROC) calibration decision analysis. found prevalence 19.62% among patients. A developed based on six influencing factors: age, educational level, pathological type, treatment program, emotional state, fatigue. for model's training validation groups 0.944 0.931, respectively. curves showed high degree consistency, (DCA) indicated good clinical applicability demonstrates discrimination, calibration, applicability, making it more intuitive predictor

Язык: Английский

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) DOI Creative Commons
Míkel Izquierdo, Philipe de Souto Barreto, Hidenori Arai

и другие.

The journal of nutrition health & aging, Год журнала: 2025, Номер 29(1), С. 100401 - 100401

Опубликована: Янв. 1, 2025

Aging, a universal and inevitable process, is characterized by progressive accumulation of physiological alterations functional decline over time, leading to increased vulnerability diseases ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) exercise, significantly modulate aging phenotypes. Physical exercise can prevent or ameliorate lifestyle-related diseases, extend health span, enhance function, reduce the burden non-communicable chronic including cardiometabolic disease, cancer, musculoskeletal neurological conditions, respiratory well premature mortality. influences cellular molecular drivers biological aging, slowing rates-a foundational aspect geroscience. Thus, PA serves both preventive medicine therapeutic agent in pathological states. Sub-optimal levels correlate with disease prevalence populations. Structured prescriptions should therefore be customized monitored like any other medical treatment, considering dose-response relationships specific adaptations necessary for intended outcomes. Current guidelines recommend multifaceted regimen that includes aerobic, resistance, balance, flexibility training through structured incidental (integrated lifestyle) activities. Tailored programs have proven effective helping older adults maintain their capacities, extending enhancing quality life. Particularly important are anabolic exercises, such Progressive resistance (PRT), which indispensable maintaining improving capacity adults, particularly those frailty, sarcopenia osteoporosis, hospitalized residential aged care. Multicomponent interventions include cognitive tasks hallmarks frailty (low body mass, strength, mobility, level, energy) thus preventing falls optimizing during aging. Importantly, PA/exercise displays characteristics varies between individuals, necessitating personalized modalities tailored conditions. Precision remains significant area further research, given global impact broad effects PA. Economic analyses underscore cost benefits programs, justifying broader integration into care adults. However, despite these benefits, far from fully integrated practice people. Many healthcare professionals, geriatricians, need more incorporate directly patient care, whether settings hospitals, outpatient clinics, Education about use isolated adjunctive treatment geriatric syndromes would do much ease problems polypharmacy widespread prescription potentially inappropriate medications. This intersection prescriptive practices offers promising approach well-being An strategy combines pharmacotherapy optimize vitality independence people whilst minimizing adverse drug reactions. consensus provides rationale promotion, prevention, management strategies Guidelines included dosages efficacy randomized controlled trials. Descriptions beneficial changes, attenuation phenotypes, role disability provided. The sarcopenia, neuropsychological emphasized. Recommendations bridge existing knowledge implementation gaps integrate mainstream Particular attention paid it applies geroscience, inter-individual variability adaptation demonstrated adult cohorts. Overall, this foundation applying current base an population span

Язык: Английский

Процитировано

33
Effects of exercise on older adults with mild cognitive impairment: A systematic review and network meta-analysis DOI Creative Commons

M. Jia,

Fengting Hu,

Yifeng Hui

и другие.

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Background: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and Alzheimer's disease (AD), with significantly elevated risk of progressing to AD. In recent years, accumulating evidence has indicated that exercise interventions may mitigate decline in individuals MCI reduce the conversion AD, potentially through mechanisms such as enhancing cerebral blood flow promoting neuroplasticity. Objective: To explore which type is most effective improving global cognition older adults investigate whether can enhance their balance abilities. Methods: Randomized controlled trials were retrieved from four databases. Stata software was used for Network Meta-Analysis traditional meta-analysis. Results: A total 33 studies included, 28 determine best modality. The results multicomponent (SUCRA = 76.5%) moderate-intensity aerobic 73.6%) are two modalities. meta-analysis showed combined training, exercise, resistance land-based kayaking training improve ability. Conclusions: Multicomponent be optimal modality MCI, various modalities However, more larger sample sizes higher quality needed provide further evidence.

Язык: Английский

Процитировано

1
Principais estratégias de treinamento para pessoas idosas portadoras de doença de Alzheimer: estudo de revisão DOI Open Access
Igor Conterato Gomes

Brazilian Journal of Health Review, Год журнала: 2025, Номер 8(1), С. e76714 - e76714

Опубликована: Янв. 10, 2025

A doença de Alzheimer (DA) é a etiologia mais comum entre as demências, correspondendo 60% dos quadros demenciais e tende se intensificar com o envelhecimento populacional. prática exercício físico proporciona efeitos benéficos um grande número agravos relacionados à DA. Além disso, tem anti-inflamatórios antioxidantes menos colaterais do que os medicamentos. Muitos estudos recomendam seu uso no tratamento da DA, dada crescente evidência para apoiar seus positivos na saúde mental, doenças neurodegenerativas demências. No entanto, profissionais movimento precisam estar atualizados sobre estratégias treinamento efetivas eficazes essa população. Dessa forma, objetivo desse estudo revisão foi refletir, baseado em evidências científicas, das principais (aeróbio, resistido multicomponente) pessoas portadoras Entre apresentadas, multicomponente apresentou maior respaldo literatura melhora aspectos relacionado além qualidade vida depressão, sendo institucionalizadas ou não.

Процитировано

0
TaiChi-MSS protocol: enhancing cognitive and brain function in MCI patients through Tai Chi exercise combined with multisensory stimulation DOI Creative Commons

Chunhui Zhou,

Ganfeng Yang, Yinying Wang

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Фев. 25, 2025

The aging population in China is confronted with considerable challenges, 14.71% of elderly individuals affected by mild cognitive impairment (MCI). practice Tai Chi has been demonstrated to enhance function, while sensory stimulation shown facilitate neural activity. Nevertheless, the combined impact and on cognitive, functions, brain activation older adults MCI remains uncertain. This study aims ascertain whether integration can more efficacious interventions for these outcomes. TaiChi-MSS (Tai Multisensory Stimulation Cognitive Function) a multi-center, randomized controlled trial (RCT) conducted Suzhou Shanghai, enrolling 88 participants aged 60 years or MCI. Participants will be randomly assigned one four groups: Chi, multisensory stimulation, control. intervention last 6 months, follow-up assessments at 3, 6, 9 months. Primary outcomes include assessments, assessed using Montreal Assessment (MoCA), Mini-Mental State Examination (MMSE), domain-specific tests, Pure Tone Audiometry (PTA), Sniffin' Sticks Odor Identification Test. Secondary involve activation, measured through functional Magnetic Resonance Imaging (fMRI) scans. fMRI used assess structure connectivity changes, focusing neuroplasticity. Data analyzed mixed-effects models. False Discovery Rate (FDR) correction method multiple comparisons control expected proportion false positives. was approved ethics committee Shanghai University Sport (No. 102772023RT200). results this disseminated peer-reviewed journals presented academic conferences.

Язык: Английский

Процитировано

0
Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations DOI Creative Commons

Zijiao Liu,

Jun Zhang, Jiang Fei

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(4)

Опубликована: Апрель 1, 2025

ABSTRACT Backgrounds Dementia can impose a heavy economic burden on both society and families. Alzheimer's disease (AD), the most prevalent form of dementia, is complex neurodegenerative characterized by abnormal deposition extracellular amyloid β‐protein (Aβ) aggregation intracellular Tau protein to neurofibrillary tangles (NFTs). Given limited efficacy pharmacological treatment, scientists have already paid more attention non‐pharmacological strategies, including dietary restriction (DR). DR refers nutritional paradigm aimed at promoting overall health modifying balance between energy consumption expenditure. Studies demonstrated that effectively extends healthy lifespan, delays aging process, achieves promising results in prevention treatment AD preclinical studies. Methods In this review we collected related studies viewpoints searching PubMed database using keywords. Most citations were published 2015 2025. A few older literatures also included due their relevance significance field. Results We first provide concise overview current therapeutic preventive strategies for AD. Then, introduce several specific protocols favorable effects Furthermore, potential mechanisms underlying benefits are discussed. Finally, briefly highlight role maintaining brain health. Conclusion This may offer valuable insights into development innovative treatment.

Язык: Английский

Процитировано

0
Physical Activity to Counter Age-Related Cognitive Decline: Benefits of Aerobic, Resistance, and Combined Training—A Narrative Review DOI Creative Commons
Wissem Dhahbi, Walid Briki, Andreas Heißel

и другие.

Sports Medicine - Open, Год журнала: 2025, Номер 11(1)

Опубликована: Май 17, 2025

With the increase in life expectancy, age-related cognitive decline has become a prevalent concern. Physical activity (PA) is increasingly being recognized as vital non-pharmacological strategy to counteract this decline. This review aimed (i) critically evaluate and synthesize impact of different PA exercise modalities (aerobic, resistance, concurrent training) on health overall well-being older adults, (ii) discuss influence intensity functions, (iii) elucidate potential mechanisms through which may enhance or mitigate performance among adults. An exhaustive analysis peer-reviewed studies pertaining PA/exercise adults from January 1970 February 2025 was conducted using PubMed, Scopus, Web Science, PsycINFO, MEDLINE. There compelling evidence that aerobic resistance training (RT) improve function mental with benefits influenced by type exercise. Specifically, moderate-intensity appears bolster memory, executive mood regulation, potentially increased cerebral blood flow, neurogenesis, production brain-derived neurotrophic factors hippocampus. Moderate-to-high-intensity RT acutely enhances visuospatial processing chronic promoting possibly stimulating insulin-like growth factor-1 augmenting flow prefrontal cortex. Findings related effects are heterogeneous, some reporting no significant others revealing substantial improvements. However, emerging indicates combination tasks (i.e., dual tasks) particularly effective, often outperforming alone. Regular beneficial for their well-being. engaging exercises moderate-to-high-intensity safe effective improving demographic. These exercises, can be conveniently incorporated into daily routines, effectively agility, function, mood. The findings mixed, indicating effectiveness combined Key Points - Moderate-intensity associated improvements linked structural functional changes brain such hippocampal volume elevated levels factor. training, both acute forms, functions processing. Cognitive benefits, including information-processing speed, attention, sustained regular training. mixed. combining dual-task outperforms mediated oxygen delivery, enhanced reduced oxidative stress inflammation, positive hormonal changes. While optimal dosage remains undetermined, empirical correlation between

Язык: Английский

Процитировано

0
Neurotechnological Approaches to Cognitive Rehabilitation in Mild Cognitive Impairment: A Systematic Review of Neuromodulation, EEG, Virtual Reality, and Emerging AI Applications DOI Creative Commons
Evgenia Gkintoni, Stephanos P. Vassilopoulos, Γεώργιος Νικολάου

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(6), С. 582 - 582

Опубликована: Май 28, 2025

Background/Objectives: Mild Cognitive Impairment (MCI) represents a clinical syndrome characterized by cognitive decline greater than expected for an individual’s age and education level but not severe enough to significantly interfere with daily activities, variable trajectories that may remain stable, progress dementia, or occasionally revert normal cognition. This systematic review examines neurotechnological approaches rehabilitation in MCI populations, including neuromodulation, electroencephalography (EEG), virtual reality (VR), training, physical exercise, artificial intelligence (AI) applications. Methods: A following PRISMA guidelines was conducted on 34 empirical studies published between 2014 2024. Studies were identified through comprehensive database searches included if they employed interventions targeting outcomes individuals MCI. Results: Evidence indicates promising across multiple intervention types. Neuromodulation techniques showed beneficial effects memory executive function. EEG analyses characteristic neurophysiological markers of potential early detection monitoring. Virtual enhanced assessment sensitivity engagement ecologically valid environments. training demonstrated the most excellent efficacy multi-domain, adaptive approaches. Physical exercise yielded improvements neurobiological pathways. Emerging AI applications personalized predictive modeling algorithms. Conclusions: Neurotechnological offer avenues rehabilitation, substantial evidence integrated mechanisms. Neurophysiological monitoring provides valuable biomarkers diagnosis treatment response. Future research should focus more extensive trials, standardized protocols, accessible implementation models translate these technological advances into practice.

Язык: Английский

Процитировано

0
Blocking progression from intervenable mild cognitive impairment to irreversible dementia, what can we do? DOI Open Access

Yaohan Peng,

Peipei Song,

Takashi Karako

и другие.

BioScience Trends, Год журнала: 2024, Номер 18(5), С. 409 - 412

Опубликована: Окт. 10, 2024

With the rapid growth of elderly population, dementia has become a global challenge that governments must address. Given incurable nature dementia, rehabilitation interventions starting in mild cognitive impairment (MCI) stage may offer solution. For intervention to be implemented as early possible, existing problems identification MCI and development MCI-specific forms addressed. Use computer technologies such virtual reality artificial intelligence might helpful overcoming these problems. Multi-disciplinary integrated approaches should direction dementia-related takes future. In addition rehabilitation, prevention decline through public community-based services for more reasonable approach.

Язык: Английский

Процитировано

2
Development and validation of a risk prediction model for cognitive impairment in breast cancer patients DOI Creative Commons
Xinmiao Zhang, Jingsong Lu,

Zhangyi Ding

и другие.

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 15, 2024

Breast cancer patients often experience cognitive impairment as a complication during treatment, which seriously affects their quality of life. This study aimed to assess the risk factors associated with in breast and construct validate nomogram model predict this population. In study, we used convenience sampling method select 423 who attended Department Surgery at First Hospital Jinzhou Medical University from September 2023 March 2024. We analyzed these patients' through LASSO regression logistic analysis develop predictive model. The was evaluated using area under curve (AUC) receiver operating characteristic (ROC) calibration decision analysis. found prevalence 19.62% among patients. A developed based on six influencing factors: age, educational level, pathological type, treatment program, emotional state, fatigue. for model's training validation groups 0.944 0.931, respectively. curves showed high degree consistency, (DCA) indicated good clinical applicability demonstrates discrimination, calibration, applicability, making it more intuitive predictor

Язык: Английский

Процитировано

2