Metabolic diseases and interferon immune responses
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
Metabolic
diseases,
including
obesity,
diabetes,
and
metabolic‐associated
fatty
liver
disease
(MAFLD),
are
increasingly
common
worldwide,
posing
a
significant
public
health
challenge.
Recent
research
has
revealed
complex
interplay
between
these
metabolic
disorders
interferon
(IFN)
immune
responses.
As
key
regulators,
interferons
coordinate
the
host's
defense
against
viral
infections
essential
for
maintaining
homeostasis.
However,
dysregulation
can
significantly
disrupt
IFN
signaling
pathways,
affecting
intensity
efficiency
of
Conversely,
alterations
in
influence
onset
progression
diseases.
This
review
explores
mechanisms
by
which
diseases
modulate
responses,
focusing
on
how
MAFLD
alter
signaling.
Additionally,
we
examine
implications
changes
responses
By
synthesizing
current
research,
this
aims
to
elucidate
offering
insights
future
clinical
applications
field
IFN‐related
Язык: Английский
Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Ноя. 13, 2024
Pelvic
organ
prolapse
(POP)
and
urinary
incontinence
(UI)
are
common
disorders
that
significantly
impact
women's
quality
of
life.
Studies
have
demonstrated
cytokines,
including
pro-
anti-inflammatory
immune
mediators,
play
a
role
in
illness
genesis
progression.
Research
on
the
inflammatory
milieu
pelvic
floor
has
shown
POP
patients
increased
inflammation
vaginal
tissues.
This
evidence
revealed
significant
changes
an
aspect
pathogenesis
POP.
exhibit
levels
cytokines
(IL-1,
TNF,
IFN,
others)
front
wall,
which
may
alter
collagen
metabolism
contribute
to
indicate
such
as
IL-6,
IL-10,
TGF,
involved
inflammation,
remodelling,
repair,
dual
effects
UI.
They
can
promote
tissue
healing
regeneration
but
also
exacerbate
fibrosis,
contributing
progression
these
conditions.
Understanding
roles
could
help
us
improve
microenvironment
women
treat
Given
considerable
this
review
addresses
studies
published
between
2000
2024
molecular
mechanisms
by
affect
with
Furthermore,
we
explain
novel
therapeutic
strategies
for
cytokine
regulation,
emphasizing
possibility
personalized
treatments
address
underlying
vagina
UI
patients.
thorough
analysis
aims
establish
foundation
future
research
clinical
applications,
ultimately
improving
patient
outcomes
via
designed
cytokine-based
therapies.
Язык: Английский
Research Progress on the Role of Inflammatory Cytokines and Molecular Mechanisms in Bone Metabolism in Postmenopausal T2DM
Journal of Clinical Personalized Medicine,
Год журнала:
2025,
Номер
04(02), С. 193 - 201
Опубликована: Янв. 1, 2025
Язык: Английский
The interleukin gene landscape: understanding its influence on inflammatory mechanisms in apical periodontitis
Tuqa Z. Omran,
Fatima Salem Obaid Al Jasmi,
Kawthar Mahdi Obaid
и другие.
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Апрель 7, 2025
Язык: Английский
Nonlinear Relationship Between Monocyte‐to‐Lymphocyte Ratio and Bone Mineral Density in Type 2 Diabetes Mellitus: Mediating Role of Fat Distribution
Clinical Endocrinology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 7, 2025
ABSTRACT
Objective
The
objective
of
study
is
to
clarify
the
relationship
between
monocyte‐to‐lymphocyte
ratio
(MLR)
and
lumbar
spine
bone
mineral
density
(BMD)
in
type
2
diabetes
mellitus
(T2DM),
analyse
mediating
role
fat
distribution,
providing
a
new
indicator
for
early
diagnosis
osteoporosis
T2DM.
Methods
A
total
430
T2DM
patients
over
50
years
were
included.
Subjects
divided
into
T1,
T2
T3
three
groups
based
on
MLR.
adjusted
regression
models,
subgroup
analysis,
generalised
additive
model
(GAM),
smoothed
curve
fitting,
mediated
effects
analysis
methods
used.
Results
results
indicated
significant
negative
correlation
MLR
BMD
(
β
=
−0.701;
95%CI:
−0.112,
−0.290).
Subgroup
fitting
threshold
effect
showed
nonlinear
BMD,
with
an
optimal
inflection
point
at
value
0.1266.
Additionally,
visceral
subcutaneous
area
(VSR)
was
negatively
correlated
−0.775;
−1.007,
−0.504).
Mediation
VSR
that
estimate
−0.0717,
direct
−0.0524,
mediation
−0.0193,
proportion
accounting
26.88%
effect.
Conclusion
significantly
associated
Higher
levels
reduced
BMD.
plays
this
relationship,
highlighting
MLR's
potential
utility
importance
management
health.
Язык: Английский
Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets
Fei Yang,
Changshun Chen,
Rongjin Chen
и другие.
Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 686 - 686
Опубликована: Май 8, 2025
Osteoporosis
(OP)
is
a
prevalent
metabolic
bone
disease,
with
several
million
cases
of
fractures
resulting
from
osteoporosis
worldwide
each
year.
This
phenomenon
contributes
to
substantial
increase
in
direct
medical
expenditures
and
poses
considerable
socioeconomic
burden.
Despite
its
prevalence,
our
understanding
the
underlying
mechanisms
remains
limited.
Recent
studies
have
demonstrated
involvement
serum
glucocorticoid-regulated
protein
kinase
1
(SGK1)
multiple
signaling
pathways
that
regulate
metabolism
significant
role
development
osteoporosis.
Therefore,
it
great
significance
deeply
explore
mechanism
SGK1
therapeutic
potential.
In
this
paper,
we
present
comprehensive
review
structure
activation
SGK1,
biological
function,
different
types
osteoporosis,
inhibitors
SGK1.
The
aim
comprehensively
assess
latest
research
progress
regards
SGK1’s
clarify
regulation
potential
as
target,
lay
foundation
for
novel
strategies
personalized
treatment
future.
Furthermore,
by
thoroughly
examining
interactions
between
other
molecules
or
pathways,
biomarkers
may
be
identified,
thereby
enhancing
efficacy
early
screening
intervention
Язык: Английский
From malaria fighter to diabetes guardian: the emerging role of artesunate in treating diabetes and diabetic complications
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 22, 2025
Diabetes
mellitus
(DM)
is
a
metabolic
disease
influenced
by
both
genetic
and
environmental
factors.
The
global
incidence
of
DM
rising,
its
multiple
complications
seriously
affect
patients'
quality
life
create
huge
economic
burden.
At
present,
the
prevention
treatment
mainly
rely
on
oral
or
subcutaneous
drugs,
although
drugs
are
more
acceptable,
they
may
produce
side
effects
have
limited
effect
diabetic
complications.
Artesunate
(ART)
first-line
antimalarial
drug
widely
used
worldwide.
Whether
orally
intravenously,
ART
has
high
bioavailability
excellent
pharmacokinetic
properties
in
humans,
shown
good
tolerance
safety
patients
ages.
Recent
pharmacological
studies
that,
except
for
properties,
also
wide
range
therapeutic
potential
This
review
aims
to
synthesize
latest
research
results,
summarize
discuss
current
role
mechanism
improving
diabetes
complications,
provide
theoretical
basis
subsequent
exploration
anti-diabetes
development
new
antidiabetic
agents
based
ART,
which
great
clinical
significance
strengthening
Язык: Английский