Tianma Gouteng Decoction improve neuronal synaptic plasticity and oligodendrocyte apoptosis in Parkinson's disease mice
Phytomedicine,
Год журнала:
2025,
Номер
140, С. 156553 - 156553
Опубликована: Фев. 25, 2025
Язык: Английский
From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research
Chinese Medical Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Abstract
The
high
failure
rates
in
clinical
drug
development
based
on
animal
models
highlight
the
urgent
need
for
more
representative
human
biomedical
research.
In
response
to
this
demand,
organoids
and
organ
chips
were
integrated
greater
physiological
relevance
dynamic,
controlled
experimental
conditions.
This
innovative
platform—the
organoids-on-a-chip
technology—shows
great
promise
disease
modeling,
discovery,
personalized
medicine,
attracting
interest
from
researchers,
clinicians,
regulatory
authorities,
industry
stakeholders.
review
traces
evolution
organoids-on-a-chip,
driven
by
necessity
advanced
biological
models.
We
summarize
applications
of
simulating
pathological
phenotypes
therapeutic
evaluation
technology.
section
highlights
how
integrating
technologies
chips,
such
as
microfluidic
systems,
mechanical
stimulation,
sensor
integration,
optimizes
organoid
cell
types,
spatial
structure,
functions,
thereby
expanding
their
applications.
conclude
addressing
current
challenges
offering
insights
into
prospects.
advancement
is
poised
enhance
fidelity,
standardization,
scalability.
Furthermore,
integration
cutting-edge
interdisciplinary
collaborations
will
be
crucial
progression
Язык: Английский
Blood–brain barrier disruption: a pervasive driver and mechanistic link between traumatic brain injury and Alzheimer's disease
Translational Neurodegeneration,
Год журнала:
2025,
Номер
14(1)
Опубликована: Март 26, 2025
Abstract
Traumatic
brain
injury
(TBI)
has
emerged
as
a
significant
risk
factor
for
Alzheimer’s
disease
(AD),
complex
and
devastating
neurodegenerative
disorder
characterized
by
progressive
cognitive
decline
memory
loss.
Both
conditions
share
common
feature:
blood‒brain
barrier
(BBB)
dysfunction,
which
is
believed
to
play
pivotal
role
in
linking
TBI
the
development
of
AD.
This
review
delves
into
intricate
relationship
between
AD,
with
focus
on
BBB
dysfunction
its
critical
mechanisms
therapeutic
development.
We
first
present
recent
evidence
from
epidemiological
studies
highlighting
increased
incidence
AD
among
individuals
history
TBI,
well
pathological
animal
model
that
demonstrate
how
can
accelerate
AD-like
pathology.
Next,
we
explore
may
mediate
TBI-induced
Finally,
investigate
shared
molecular
pathways
associated
both
discuss
latest
findings
targeting
these
employing
regenerative
approaches,
such
stem
cell
therapy
pharmacological
interventions,
enhance
function
mitigate
neurodegeneration.
Язык: Английский