Biochemical and immunological insights into COVID-19 multi system involvement in Iraqi patients

Regulatory Mechanisms in Biosystems, Год журнала: 2025, Номер 33(1), С. e25025 - e25025

Опубликована: Фев. 9, 2025

The emergence of COVID-19 has created a serious and pressing international public health emergency. In cases infection, biomarkers may be employed to detect severity the disease as reflected by level some infla m matory mediators such as; IL-6, IL-8 CRP. This case control study was performed examine demographic charact e ristics, biochemical inflammatory meditators in Iraqi patients diagnosed with who were admitted Al-Sheffa 14 Hospital, Kirkuk, Iraq for management. included cohort 100 infection depending on clinical features , which confirmed PCR testing. Those hospital during period from November 2021 March 2022. Demographic data age gender gathered group 30 sex matched healthy persons also included. following serum (ALT, AST, ALP, u rea, c reatinine, v itamin D LDH), (CRP, d imer ferritin) immunological (Il-6 Il-8) measured compared those group. range ’ 31–81 years is statistically not different that (31–90 years). (54% female, 46% male) (53.3% females, 46.7% males) groups have similar distribution. Among p tients group, greater incidence among individuals aged 61–70 while lowest 31–40 These observations indicate higher all above abnormalities relative control. Correlation analyses showed significant connections between D-dimer vitamin levels, well IL-6 levels COVID-19. displayed clear dem o graphic traits notable biochemical, indicators when persons. work highlights significance integrating these discoveries into risk assessment models patient care methods

Язык: Английский

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The Characteristics of Patients With COVID‐19–Associated Pediatric Vasculitis: An International, Multicenter Study

Arthritis & Rheumatology, Год журнала: 2022, Номер 75(4), С. 499 - 506

Опубликована: Дек. 2, 2022

COVID-19-associated pediatric vasculitis, other than Kawasaki disease (KD)-like vasculitis in multisystem inflammatory syndrome children (MIS-C), is very rare. This study sought to analyze the characteristics, treatment, and outcomes patients with (excluding KD-like MIS-C).The inclusion criteria were as follows: 1) age <18 years at onset; 2) evidence of vasculitis; 3) SARS-CoV-2 exposure; 4) ≤3 months between exposure onset. Patients MIS-C excluded. The features subset our cohort who had IgA vasculitis/Henoch Schönlein purpura (IgAV/HSP) compared against a pre-pandemic IgAV/HSP patients.Forty-one (median 8.3 years; male female ratio 1.3) included from 14 centers 6 countries. most frequent subtype was (n = 30). median duration onset 13 days. Involvement skin (92.7%) gastrointestinal system (61%) common manifestations vasculitis. Most (68.3%) received glucocorticoids, 14.6% also additional immunosuppressive drugs. Remission achieved all patients. All manifestations, while 18 (60%) involvement (43.3%) renal involvement. When we this 30 those 159), clinical characteristics fever more (fever, 30% versus 5%, respectively [P < 0.001]; involvement, 43.3% 17.6%, 0.002]). Recovery without treatment complete recovery each less among (recovery 10% 39%, 0.002]; recovery, 86.7% 99.4%, 0.002]).This largest MIS-C) studied date. Our findings suggest that experience severe course before pandemic.

Язык: Английский

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COVID-19 and Intestinal Ischemia: A Multicenter Case Series

Frontiers in Medicine, Год журнала: 2022, Номер 9

Опубликована: Май 18, 2022

Introduction Gastrointestinal symptoms are common among COVID-19 patients. Although gastrointestinal involvements mostly benign, they rarely indicate a severe pathology like intestinal ischemia. The present case series describes 21 patients with bowel ischemia, necrosis, or perforation. Methods was conducted from April 2020 to February 2022 in the surgical wards of two Iranian hospitals. We retrospectively included adult concomitant and Primary outcomes were defined as length stay survival. Results Twenty-four median age 61.5 years study. Sixteen (67%) male, 13 (54%) without any comorbidities. Macrovascular mesenteric ischemia not identified (87.5%). manifestations appeared on seven days (range 2–21) after diagnosis COVID-19, most symptom being abdominal pain. All had significantly elevated C-Reactive Protein prior surgery, ranging 68 362. D-dimer measured eight elevated, 1,878 over 5,000 ng/mL. One patient managed conservatively due good clinical condition. Except for one angioinvasive mucormycosis other leukocytoclastic vasculitis, pathologic evaluation revealed general features including ulcer, hemorrhage, neutrophilic infiltration (in patients), abscess four edema. Bowel necrosis accompanied mortality 15 (62.5%) 6.5 hospital stay. Conclusion Intestinal is associated high rate. Further research needed elucidate dynamics setting COVID-19.

Язык: Английский

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Severe stroke in patients admitted to intensive care unit after COVID-19 infection: Pictorial essay of a case series

Brain Hemorrhages, Год журнала: 2021, Номер 3(1), С. 29 - 35

Опубликована: Дек. 13, 2021

Patients infected by COVID-19 could require intensive care unit admission especially due to acute respiratory failure. However, neurological manifestations are very common. Among these, ischemic stroke or cerebral hemorrhage may have unfavorable outcome. The mechanisms leading damage SARS-CoV2 still under debate. One of the most accepted theories implies an endothelial activation which in turns increase risk thrombus formation with development stroke, either hemorrhagic. more severe disease, higher stroke. Stroke ICU patients not frequent, but has devastating effects high mortality. In these pictorial essay case reports, main clinical aspects discussed, along a summary evidence about pathophysiology and treatment patients.

Язык: Английский

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Acute mesenteric arterial thrombosis in severe SARS-Co-2 patient: A case report and literature review

International Journal of Surgery Case Reports, Год журнала: 2021, Номер 86, С. 106307 - 106307

Опубликована: Авг. 11, 2021

CoV-2 infection generates a pro-inflammatory state, which conditions the formation of thrombi that can affect any system. Multi-organ dysfunction is cause death, mesenteric ischemia in COVID 2019 patients reported 1.9-4%.We present case 73-year-old male patient who started with severe SARS-CoV-2 and arterial-type intestinal ischemia, necrosis 3 m small intestine, based on SCARE 2020 guide.Complications secondary to thrombosis are as follows; myocardial infarction 1.1%, ischemic cerebral events, 2.5-3.7%, microvascular including less than 1% cases. In postoperative mortality 23.8% especially during first 30 days.Intestinal increases mortality.

Язык: Английский

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