Association of combined pulmonary fibrosis and emphysema in rheumatoid arthritis with high titer of rheumatoid factor and autoimmunity to the lung

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Background Combined pulmonary fibrosis and emphysema (CPFE) commonly coexists with connective tissue diseases (CTD), such as rheumatoid arthritis (RA). However, the risk factors contributing to development of CTD-CPFE remain largely unidentified. This study aimed characterize CPFE using a large cohort consecutive RA patients elucidate potential associated RA- development. Methods A total 976 were enrolled in this cross-sectional RA-CPFE. Multiple logistic analyses conducted identify for RA-CPFE Patient IgG IgM autoantibodies primary human bronchial epithelial cells (HBEC) from healthy donors assessed flow cytometry. Findings Among patients, 414 (42.4%) developed interstitial lung disease (ILD), 74 (7.6%) experiencing CPFE. In comparison centrilobular or paraseptal emphysema, those panacinar had higher scores decreased function parameters. regression analysis revealed that male gender, cigarette smoking, occupational exposure dust, high ILD score, factor (RF) titers, presence anti-SSA an increased Additionally, levels HBEC elevated compared controls positively correlated RF levels. Interpretation is first demonstrate association titer against HBEC, suggesting link between autoimmunity

Язык: Английский

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Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus

Autoimmunity Reviews, Год журнала: 2024, Номер 23(7-8), С. 103581 - 103581

Опубликована: Июль 1, 2024

Язык: Английский

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Identification of TRAPPC4 as a Key Autoantigen in Immune-Related Pancytopenia: Epitope Characterization and Immune Activation Mechanisms

Turkish Journal of Hematology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Immune-related pancytopenia (IRP) is characterized by autoantibody-mediated destruction or suppression of bone marrow cells, leading to pancytopenia. This study aimed explore the role TRAPPC4 (trafficking protein particle complex subunit 4) as a key autoantigen in IRP, including epitope identification and immune activation mechanisms. A total 90 participants were included study, divided into four groups: 30 newly diagnosed IRP patients, 25 remission 20 patients with control hematologic conditions (severe aplastic anemia [SAA] myelodysplastic syndrome [MDS]), 15 healthy controls. was identified using affinity screening phage random peptide library confirmed ELISPOT prediction software. expression cells serum antibody titers assessed via flow cytometry, ELISA, real-time PCR. Immune cell profiling peripheral blood mononuclear (PBMNCs) conducted cytometry. overexpressed on CD34+ hematopoietic progenitor compared disease controls (SAA MDS), controls, no significant differences observed CD15+ granulocytes CD235a+ nucleated red cells. The YTADGKEVLEYLG activated Th2 ELISPOT. Newly exhibited elevated mRNA levels higher revealed increased CD19+ CD5+CD19+ B lymphocytes patients. found along primary targets autoantibody attacks. its provided insights pathogenesis suggested potential diagnostic therapeutic strategies.

Язык: Английский

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Frequency of autoantibodies and their associated clinical characteristics and outcomes in patients with dilated cardiomyopathy: A systematic review and meta-analysis

Autoimmunity Reviews, Год журнала: 2025, Номер 24(4), С. 103755 - 103755

Опубликована: Янв. 22, 2025

Dilated cardiomyopathy (DCM) is a prevalent myocardial disorder characterized by impaired cardiac function affecting either the left ventricle or both ventricles. Accumulating evidence suggests that autoimmunity represents key mechanism implicated in its pathogenesis, as several abundant autoantibodies have been identified patients with condition. However, prevalence of these antibodies (Abs) DCM compared to healthy controls (HCs) and those ischemic (ICM), well their potential association DCM, remains unclear. This study aimed elucidate certain HCs ICM, evaluate correlation clinical characteristics outcomes. A comprehensive literature search PubMed, Web Science, EMBASE, Cochrane Library, Scopus was conducted up March 26, 2024, any article fulfilled our inclusion criteria reviewed. meta-analysis then conducted, using random- fixed-effects models. total 38 studies met were pulled for this analysis. Significantly higher rates targeting anti-β1 adrenergic receptor (β1-AR; odds ratio [OR] = 4.96, p 0.000), M2 muscarinic (M2-R; OR 4.07, adenine nucleotide translocator (ANT; 21.18, 0.001) myosin (OR 12.26, 0.000) observed HCs. Moreover, exhibited significantly frequency positive ANT Abs 34.52, 0.005) ICM. Regarding outcomes, seropositivity β1-AR found be correlated New York Heart Association (NYHA) classification (standardized mean difference [SMD] 0.78, 0.006), ventricular ejection fraction (LVEF) (SMD -1.38, 0.001), heart rate (HR) 1.505, 0.022). Seropositivity anti‑calcium channel associated sudden death (SCD; 3.17, all-cause mortality 2.06, 0.008), while anti-troponin I (TnI) atrial fibrillation 0.21, 0.042). In terms Ab rates, significant heterogeneity anti-β1-AR between investigating ICM may partially explained detection methods used ages patients. Meta-regression analysis suggested patients' explain regarding HR. comparing prevalences vs characteristics, could not subgroup analyses demographic factors such age sex-nor function. Patients are more likely elevated levels anti- β1-AR, M2-R, HCs, Anti-β1-AR, calcium channel, TnI play an essential role severity poor prognosis. first autoantibody thus potentially guide management further research warranted accuracy presumed owing small number included high degree heterogeneity.

Язык: Английский

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Chronische Schmerzsyndrome bei muskuloskelettalen Erkrankungen – wie verschieden sind Fibromyalgie und Long COVID? – Teil 1

Zeitschrift für Rheumatologie, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

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Cerebral Malaria as an Autoimmune-like Disease Driven by Pathogenic B cell Responses and Systemic Inflammation

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Cerebral malaria (CM) is a life-threatening complication of Plasmodium infection, traditionally attributed to parasite sequestration and inflammation. Here, we identify the spleen as central driver systemic lethal inflammation, with B cell-mediated humoral immunity playing key role in disease progression. Single-cell sequencing reveals that GLUT1⁺ marginal zone macrophages (MZMs) activate cells promote autoantibody production, amplifying immunopathology. To counter this process, develop Glutoborin, GLUT1-specific proteasome inhibitor, which disrupts MZM-B cell interactions, suppresses activation, alleviates ultimately protecting against CM. Mechanistically, proteomic analysis identifies anti-CD36 antibodies autoantibodies driving CM pathogenesis, triggering complement-dependent cytotoxicity platelets endothelial while activating through CD36-TLR4 axis, further exacerbating These findings redefine an autoimmune-driven highlight Glutoborin promising therapeutic strategy.

Язык: Английский

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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA‐A*3303 and HLA‐DPB1*0501

Annals of Neurology, Год журнала: 2024, Номер 95(5), С. 901 - 906

Опубликована: Фев. 24, 2024

We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that GFAP astrocytopathy was associated with HLA-A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] 1.32-3.06, p 0.00072,

Язык: Английский

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Anti-CCP biosensors in rheumatoid arthritis

Clinica Chimica Acta, Год журнала: 2024, Номер 561, С. 119767 - 119767

Опубликована: Июнь 10, 2024

Язык: Английский

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The application potential of iMSCs and iMSC-EVs in diseases

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Июль 29, 2024

The immune system, functioning as the body's "defense army", plays a role in surveillance, defense. Any disruptions system can lead to development of immune-related diseases. Extensive researches have demonstrated crucial immunoregulatory mesenchymal stem cells (MSCs) these Of particular interest is ability induce somatic under specific conditions, generating new cell type with characteristics known induced pluripotent (iPSC). differentiation iPSCs into MSCs, specifically cell-derived (iMSCs), hold promise potential solution challenges potentially serving an alternative traditional drug therapies. Moreover, products iMSCs, termed extracellular vesicles (iMSC-EVs), may exhibit functions similar iMSCs. With biological advantages EVs, they become focus "cell-free therapy". Here, we provided comprehensive summary impact iMSCs on cells, explored applications and iMSC-EVs diseases, briefly discussed fundamental EVs. Finally, overviewed current associated iMSC-EVs. It our hope that this review related will contribute approaches for treatment

Язык: Английский

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Association of Angiotensin II Receptor Type 1 and Endothelin‐1 Receptor Type A Agonistic Autoantibodies With Adverse Remodeling and Cardiovascular Events After Acute Myocardial Infarction

Journal of the American Heart Association, Год журнала: 2024, Номер 13(4)

Опубликована: Фев. 13, 2024

The left ventricular remodeling (LVR) process has limited the effectiveness of therapies after myocardial infarction. relationship between autoantibodies activating AT1R-AAs (angiotensin II receptor type 1-AAs) and ETAR-AAs (autoantibodies endothelin-1 A) with infarction been described. Among patients ST-segment-elevation infarction, we investigated these LVR subsequent major adverse cardiac events.

Язык: Английский

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