Autoantibodies in COVID-19 survivors with post-COVID symptoms: a systematic review
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 5, 2024
Objective
The
long-lasting
persistence
of
autoantibodies
stands
as
one
the
hypotheses
explaining
multisystemic
manifestations
seen
in
individuals
with
post-COVID-19
condition.
current
review
offers
restricted
insights
into
plasma/serum
people
post-COVID
symptoms.
Methods
PubMed/MEDLINE,
CINAHL,
EMBASE,
and
Web
Science
databases,
well
on
medRxiv
bioRxiv
preprint
servers
were
searched
up
to
January
5
th
,
2024.
Papers
investigating
presence
samples
symptoms
included.
Newcastle-Ottawa
Scale
(NOS)
was
used
assess
methodological
quality.
Results
From
162
identified
records,
five
articles
met
all
inclusion
criteria;
four
studies
included
infected
controls
no
whereas
non-infected
(410
COVID-19
survivors
symptoms,
223
266
healthy
controls).
Four
concluded
that
had
a
potential
(but
small)
role
condition
study
not
associated.
Quality
assessment
showed
high
Conclusion
Although
evidence
suggests
persistent
can
be
associated
clinical
relevance
their
seems
modest
at
this
stage.
Current
results
highlight
further
research
clarify
development
guiding
tailored
diagnostic
treatment
approaches
enhance
patient
outcomes.
Systematic
registration
https://osf.io/vqz28
.
Язык: Английский
Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2296 - 2296
Опубликована: Фев. 15, 2024
Autoimmune
autonomic
ganglionopathy
(AAG)
is
a
disease
of
failure
caused
by
ganglionic
acetylcholine
receptor
(gAChR)
autoantibodies.
Although
the
detection
autoantibodies
important
for
distinguishing
from
other
neuropathies
that
present
with
dysfunction,
factors
are
accurate
diagnosis.
Here,
we
provide
comprehensive
review
clinical
features
AAG,
highlighting
differences
in
course,
presentation,
and
laboratory
findings
presenting
symptoms.
The
first
step
diagnosing
AAG
careful
history
taking,
which
should
reveal
whether
mode
onset
acute
or
chronic,
followed
an
examination
time
course
progression,
including
presentation
extra-autonomic
neuropathy
be
differentiated
when
patient
presents
dysfunction.
Immune-mediated
neuropathies,
such
as
sensory
neuropathy,
sometimes
difficult
to
differentiate,
therefore,
well
understood.
Other
non-neuropathic
conditions,
postural
orthostatic
tachycardia
syndrome,
chronic
fatigue
long
COVID,
also
symptoms
similar
those
AAG.
often
challenging,
efforts
made
differentiate
among
candidates.
Язык: Английский
Diagnostik und Therapie bei Post-COVID-19 und Post-Vaccination-Syndrom
Deutsche Zeitschrift für Akupunktur,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Long COVID: current research and future directions
Infectious Diseases & Immunity,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Long
coronavirus
disease
(COVID)
is
defined
as
the
continuation
or
development
of
new
symptoms
three
months
after
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection,
and
that
last
for
at
least
two
months,
with
no
other
explanation
their
cause.
This
includes
various
clinical
manifestations
affect
multiple
organ
systems,
such
complications
in
respiratory,
cardiovascular,
neurological,
musculoskeletal
systems.
The
most
commonly
reported
include
fatigue,
cognitive
dysfunction,
dyspnea,
chest
pain;
however,
prevalence
severity
these
vary
greatly
among
individuals.
underlying
mechanisms
long
COVID
are
complex
multifaceted,
encompassing
viral
persistence,
immune
system
mitochondrial
abnormalities,
endothelial
impairment,
alterations
microbiome.
Further,
has
imposed
a
significant
burden
on
individuals,
healthcare
economy
by
impairing
an
individual’s
quality
life
functional
capacity,
thereby
increasing
costs
demand
care
rehabilitation
services.
review
summarizes
definition,
phenotypes,
mechanisms,
current
treatment
advancements
highlights
specific
research
directions
future
investigation.
Язык: Английский
Link Between the G Protein-Coupled Receptor (GPCR), SARS-CoV-2 Spike Protein, ACE2, Vaccines, and Long COVID
Опубликована: Март 11, 2024
The
knowledge
of
COVID-19
impact
on
the
human
body
has
increased
rapidly.
Although
many
people
recover
from
COVID-19,
some
continue
to
experience
persistent
symptoms
that
have
been
identified
as
Long
COVID.
This
condition
can
a
severe
quality
life,
and
it
remains
significant
concern
for
medical
professionals
researchers.
One
key
components
SARS-CoV-2
virus
enables
enter
cells
is
spike
(S)
protein.
Recent
studies
revealed
complex
network
interactions
between
G
proteins,
protein,
Renin-Angiotensin
System
(RAS)
may
be
responsible,
at
least
in
part,
long
also
affect
brain,
leading
neurological
such
confusion,
memory
loss,
fatigue.
Increasing
evidence
suggests
not
just
respiratory
illness
since
likely
could
influence
signal
transduction
pathways
G-protein-coupled
receptor
(GPCR),
among
others,
either
directly
or
indirectly,
affecting
neural
functions.
These
with
protein
RAS,
alongside
are
require
deep
research
understand
their
implications
manifestation
fully.
While
recent
shed
light
angiotensin
system,
this
article
explores
these
interconnected
manifestations.
present
review
summarises
current
different
molecular
mechanisms
COVID
pathophysiology
help
identify
possible
targets
new
strategies
diagnosis
treatment.
Язык: Английский
Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19
Yulin Wei,
Hongyan Gu,
Jun Ma
и другие.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 27, 2024
Long
COVID
is
an
often-debilitating
condition
with
severe,
multisystem
symptoms
that
can
persist
for
weeks
or
months
and
increase
the
risk
of
various
diseases.
Currently,
there
a
lack
diagnostic
tools
in
clinical
practice.
Therefore,
this
study
utilizes
plasma
proteomics
metabolomics
technologies
to
understand
molecular
profile
pathophysiological
mechanisms
COVID,
providing
evidence
development
potential
biomarkers.
This
included
three
age-
gender-matched
cohorts:
healthy
controls
(
n
=
18),
COVID-19
recovered
patients
17),
15).
The
results
revealed
significant
differences
proteins
between
patients,
dysregulation
mainly
focused
on
pathways
such
as
coagulation,
platelets,
complement
cascade
reactions,
GPCR
cell
signal
transduction,
substance
transport,
which
participate
regulating
immune
responses,
inflammation,
tissue
vascular
repair.
Metabolomics
showed
have
similar
metabolic
disorders,
involving
lipid
metabolites
fatty
acid
metabolism,
glycerophospholipids,
sphingolipid
arachidonic
metabolism
processes.
In
summary,
our
indicate
protein
abnormalities
leading
coagulation
dysfunction,
impaired
energy
chronic
dysregulation,
are
more
pronounced
than
patients.
Язык: Английский
High prevalence of long COVID in anti-TPO positive euthyroid individuals with strongly elevated SARS-CoV-2-specific T cell responses and moderately raised anti-spike IgG levels 23 months post-infection
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 10, 2024
Severe
acute
respiratory
syndrome
coronavirus
type
2
(SARS-CoV-2)
infection,
the
causative
agent
of
disease
2019
(COVID-19),
causes
post-acute
infection
in
a
surprisingly
large
number
cases
worldwide.
This
condition,
also
known
as
long
COVID
or
sequelae
COVID-19,
is
characterized
by
extremely
complex
symptoms
and
pathology.
There
growing
consensus
that
this
condition
consequence
virus-induced
immune
activation
inflammatory
cascade,
with
its
prolonged
duration
caused
persistent
virus
reservoir.
Язык: Английский