Transfusion and Apheresis Science, Год журнала: 2023, Номер 63(1), С. 103848 - 103848
Опубликована: Ноя. 16, 2023
Язык: Английский
Cytokine, Год журнала: 2025, Номер 187, С. 156866 - 156866
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
0
Multiple Sclerosis and Related Disorders, Год журнала: 2025, Номер unknown, С. 106401 - 106401
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3348 - 3348
Опубликована: Апрель 3, 2025
Multiple System Atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder marked by autonomic dysfunction, parkinsonism, and cerebellar ataxia. While predominantly affecting individuals in their fifth or sixth decade, advancements assisted reproductive technologies (ART) have created new clinical scenarios involving pregnancies women within MSA's typical onset range. Given the scarcity of documented MSA pregnancies, this review leverages insights from related Parkinson's spectrum mechanisms to explore hypothetical for how pregnancy-induced physiological changes might influence progression. Pregnancy-induced hormonal fluctuations, including elevated estrogen progesterone levels, may modulate α-synuclein aggregation neuroinflammatory pathways. Immune adaptations, such as fetal microchimerism Th2-biased immune profiles, introduce additional complexities, particularly donor embryo complex microchimerism. Metabolic demands oxidative stress further intersect with these mechanisms, potentially accelerating disease We analyze existing literature theoretical models, emphasizing need interdisciplinary research. Clinical implications are discussed propose evidence-based strategies optimizing maternal-fetal outcomes. This paper identifies critical knowledge gaps proposes avenues future investigation optimize outcomes unique underexplored intersection.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 19, 2024
Background Multiple sclerosis (MS) is the most common non-traumatic disabling disease affecting young adults. A definitive curative treatment currently unavailable. Many randomized controlled trials (RCTs) have reported efficacy of Chinese herbal medicine (CHM) on MS. Because uncertain quality these RCTs, recommendations for routine use CHM MS remain inconclusive. The comprehensive evaluation RCTs urgent. Methods Nine databases, namely, PubMed, Embase, Web Science, Cochrane Library, EBSCO, Sinomed, Wanfang Database, China National Knowledge Infrastructure, and VIP were searched from inception to September 2023. comparing with placebo or pharmacological interventions considered eligible. Consolidated Standards Reporting Trials (CONSORT) its extension formulas (CONSORT-CHM Formulas) checklists used evaluate reporting RCTs. risk bias was assessed using Risk Bias tool. selection criteria high-frequency herbs those cumulative frequency over 50% among top-ranked herbs. Results total 25 included. In included 33% CONSORT items 21% CONSORT-CHM Formulas reported. Eligibility title, sample size calculation, allocation concealment, implementation, blinded description in core by less than 5% trials. For Formulas, source authentication method each ingredient particularly poorly Most studies classified as “unclear” due insufficient information. top five frequently were, order, Radix Rehmanniae Preparata , Recens Herba Epimedii Scorpio Poria . No serious adverse effect had been Conclusions low unclear indicate inadequate terms completeness result validity. appropriately consider unique characteristics CHM, including principles, formulas, medicinal substances. To improve MS, researchers should adhere more closely guidelines ensure disclosure all study design elements.
Язык: Английский
Процитировано
3
S S Korsakov Journal of Neurology and Psychiatry, Год журнала: 2024, Номер 124(7), С. 43 - 43
Опубликована: Янв. 1, 2024
Planning for pregnancy and possibility of disease modifying treatment (DMTs) is an important question in female patients reproductive age who suffer from multiple sclerosis (MS). The frequency refusals to plan 14%. This due numerous concerns about the course pregnancy, its outcomes, as well possible effect DMTs on fetus probability transmission a child. article discusses immunological reactions taking place MS during which are protective nature. Data all groups regarding planning, risks their impact fertility teratogenicity presented.
Язык: Английский
Процитировано
3
NeuroImmune Pharmacology and Therapeutics, Год журнала: 2024, Номер 3(3-4), С. 175 - 182
Опубликована: Сен. 1, 2024
Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease of the central nervous system (CNS) in which CNS-driven immune response destroys myelin, leading to wide range symptoms including numbness tingling, vision problems, mobility impairment, etc. Oligodendrocytes are myelinating cells CNS, generated from oligodendroglial progenitor (OPCs) via differentiation. However, for multiple reasons, OPCs fail differentiate oligodendrocytes MS as result, stimulating differentiation considered beneficial MS. The β-hydroxy β-methylbutyrate (HMB) widely-used muscle-building supplement human recently it has been shown that low-dose HMB capable cultured remyelination. Moreover, other causes demyelination decrease and/or suppression Foxp3-expressing anti-autoimmune regulatory T (Tregs) upregulation T-helper 1(Th1) Th17 cells. Experimental encephalomyelitis (EAE) an animal model nicely visible. It reported EAE mice, oral upregulates Tregs decreases Th1 responses, remyelination CNS. Here, we analyze these newly-described features HMB, highlighting putative promyelinating nature this supplement.
Язык: Английский
Процитировано
0
Transfusion and Apheresis Science, Год журнала: 2023, Номер 63(1), С. 103848 - 103848
Опубликована: Ноя. 16, 2023
Язык: Английский
Процитировано
0