International Journal of Human-Computer Interaction, Год журнала: 2025, Номер unknown, С. 1 - 22
Опубликована: Июнь 5, 2025
Язык: Английский
Cells, Год журнала: 2023, Номер 12(12), С. 1599 - 1599
Опубликована: Июнь 10, 2023
Apathy is commonly defined as a loss of motivation leading to reduction in goal-directed behaviors. This multidimensional syndrome, which includes cognitive, emotional and behavioral components, one the most prevalent neuropsychiatric features Parkinson’s disease (PD). It has been established that prevalence apathy increases PD progresses. However, pathophysiology anatomic substrate this syndrome remain unclear. seems be underpinned by impaired anatomical structures link prefrontal cortex with limbic system. can encountered prodromal stage fluctuating patients receiving bilateral chronic subthalamic nucleus stimulation. In these stages, may considered disorder embodies amotivational combined dopaminergic serotonergic denervation dopa-responsive. contrast, advanced patients, cognitive announces decline dementia, diffuse neurotransmitter system dysfunction Lewy pathology spreading no longer review, we discuss clinical patterns their treatment, neurobiological basis apathy, potential role involved pathways motivational apathy.
Язык: Английский
Процитировано
26
Foods, Год журнала: 2023, Номер 12(16), С. 3083 - 3083
Опубликована: Авг. 17, 2023
Due to today’s fast-paced lifestyle, most people are in a state of sub-health and face “unexplained fatigue”, which can seriously affect their health, work efficiency, quality life. Fatigue is also common symptom several serious diseases such as Parkinson’s, Alzheimer’s, cancer, etc. However, the contributing mechanisms not clear, there currently no official recommendations for treatment fatigue. Some dietary polysaccharides often used health care supplements; these have been reported specific anti-fatigue effects, with minor side effects rich pharmacological activities. Dietary be activated during food processing or gastrointestinal transit, exerting unique effects. This review aims comprehensively summarize evaluate latest advances biological processes exercise-induced fatigue, understand possible molecular alleviating systematically elaborate roles gut microbiota gut-muscle axis this process. From perspective axis, investigating relationship between fatigue will enhance our understanding may lead significant breakthrough regarding mechanism paper provide new perspectives further research into use science nutrition, could help develop potential agents open up novel therapies conditions.
Язык: Английский
Процитировано
20
International Journal of Sports Physiology and Performance, Год журнала: 2025, Номер unknown, С. 1 - 5
Опубликована: Янв. 1, 2025
Background : Mental fatigue (MF) is a psychobiological state that could negatively impact physical and cognitive performance, although the extent of this remains controversial. While laboratory studies have provided valuable insights into acute effects MF, their ecological validity in real-world sport settings limited. Recent research indicates MF can naturally arise during activities, leading to chronic on endurance perceptual-cognitive skills. These may persist beyond individual sessions, potentially increasing risk injury due cumulative nature. Purpose This commentary aims guide future by emphasizing need investigate natural occurrence applied settings. Conclusions Understanding how develops manifests settings, particularly differences perception response, crucial for creating more effective management strategies. Addressing these factors will enable better support athletes who experience prolonged periods affect training competitive performance. Future should prioritize studying enhance findings. By focusing nature as well variability, researchers develop tailored strategies managing MF. not only bridge gap between applications but also contribute precise monitoring intervention techniques. Ultimately, advancements improve athletes’ ability maintain peak performance reduce injury, thereby enhancing overall athletic well-being.
Язык: Английский
Процитировано
1
Опубликована: Март 3, 2025
Процитировано
1
PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0299634 - e0299634
Опубликована: Март 29, 2024
Multiple Sclerosis (MS) is an autoimmune disease affecting the central nervous system, characterised by neuroinflammation and neurodegeneration. Fatigue depression are common, debilitating, intertwined symptoms in people with relapsing-remitting MS (pwRRMS). An increased understanding of brain changes mechanisms underlying fatigue RRMS could lead to more effective interventions enhancement quality life. To elucidate relationship between connectivity pwRRMS we conducted a systematic review. Searched databases were PubMed, Web-of-Science Scopus. Inclusion criteria were: studied participants ( n ≥ 20; 18 years old) differentiated subtypes; published 2001-01-01 2023-01-18; used assessments validated for MS; included structural, functional magnetic resonance imaging (fMRI) or diffusion MRI (dMRI). Sixty studies met criteria: dMRI (15 fatigue, 5 depression) 22 fMRI (20 studies. The literature was heterogeneous; half reported no correlation measures depression. Positive findings showed that abnormal cortico-limbic structural associated linked cortico-thalamic-basal-ganglial networks. Additionally, both related altered cingulum connectivity, involving thalamus, cerebellum, frontal lobe, ventral tegmental area, striatum, default mode attention networks, supramarginal, precentral, postcentral gyri. Qualitative analysis suggests changes, possibly due axonal and/or myelin loss, network may underlie pwRRMS, respectively, but overall results inconclusive, explained heterogeneity limited number This highlights need further including advanced detect subtle association fatigue. Future using optimised protocols required clarify substrates these pwRRMS.
Язык: Английский
Процитировано
6
Journal of Clinical Medicine, Год журнала: 2022, Номер 11(13), С. 3886 - 3886
Опубликована: Июль 4, 2022
Fatigue is one of the most disabling symptoms in several neurological disorders and has an important cognitive component. However, relationship between self-reported fatigue objective assessment results remains elusive. Patients with post-COVID syndrome often report issues months after acute infection. We aimed to develop predictive models using neuropsychological assessments evaluate results. conducted a cross-sectional study 113 patients syndrome, assessing them Modified Impact Scale (MFIS) comprehensive battery including standardized computerized tests. Several machine learning algorithms were developed predict MFIS scores (total score score) based on test scores. showed moderate correlations only Stroop Color–Word Interference Test. Classification obtained modest F1-scores for classification non-fatigued or 3 4 degrees severity. Regression estimate did not achieve adequate R2 metrics. Our find reliable predictors syndrome. This implications interpretation assessment. Specifically, domain could properly capture actual fatigue. In addition, our findings suggest different pathophysiological mechanisms dysfunction
Язык: Английский
Процитировано
23
Biological Psychology, Год журнала: 2023, Номер 185, С. 108727 - 108727
Опубликована: Дек. 4, 2023
Fatigue-specific changes in the autonomic nervous system are often assumed to underlie development of mental fatigue caused by prolonged cognitive tasks (i.e. Time-on-Task). Therefore, several previous studies have chosen investigate Time-on-Task related heart rate variability (HRV). However, used many different HRV indices, and their results show inconsistencies. The present study, therefore, systematically reviewed empirical with healthy individuals which is induced tasks. Articles relevant objectives were searched selected applying PRISMA guidelines. We screened 360 records found on 4 databases that 19 eligible for full review accordance inclusion criteria. In general, all (with exception two studies) significant increasing Time-on-Task, suggesting a reliable marker fatigue. most conclusive indices showed consistent effect low frequency component time domain particularly root mean square successive differences. typically an trend both type measures.
Язык: Английский
Процитировано
13
Scientific Reports, Год журнала: 2022, Номер 12(1)
Опубликована: Ноя. 21, 2022
A prolonged period of cognitive performance often leads to mental fatigue, a psychobiological state that increases the risk injury and accidents. Previous studies have trained machine learning algorithms on Heart Rate Variability (HRV) data detect fatigue in order prevent its consequences. However, results these cannot be generalised because various methodological issues including use only one type task induce which makes any predictions task-specific. In this study, we combined datasets three experiments each applied different tasks for induction predict severity. We also tested time window lengths compared resting related data. found classification was best when support vector classifier HRV calculated 5-min (AUC = 0.843, accuracy 0.761). For prediction severity, CatBoost regression showed 3-min self-reported measures (R2 0.248, RMSE 17.058). These indicate both detection based are effective models heterogeneous, multi-task datasets.
Язык: Английский
Процитировано
17
Behavioral Sciences, Год журнала: 2023, Номер 13(11), С. 918 - 918
Опубликована: Ноя. 10, 2023
Prolonged cognitive effort can be considered one of the core determinants mental fatigue and may negatively affect efficacy efficiency performance. Metacognition-understood as a multi-componential set skills concerning awareness control one's own cognition-might reduce such negative outcomes. This study aimed to explore relation between metacognitive skills, neurocognitive performance, level mirrored by electrophysiological (EEG) markers load task demand. A challenging was used prompt collect metacognition reports, performance data (accuracy response times-RTs), physiological (task-related changes spectral power for standard EEG frequency bands) via wearable EEG. Data analysis highlighted that different aspects are associated with measured by, respectively, accuracy RTs. Furthermore, specific were found consistently correlated effort, regardless increasing demands. Finally, behavioral metrics mirroring information processing depending on low or high demand imposed task.
Язык: Английский
Процитировано
11
PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0316252 - e0316252
Опубликована: Янв. 3, 2025
Introduction Mental fatigue, a psychobiological state induced by prolonged and sustained cognitive tasks, impairs both physical performance. Several studies have investigated strategies to counteract mental fatigue. However, potential health risks contextual restrictions often limit these strategies, which hinder their practical application. Due its noninvasive portable nature, music has been proposed as promising strategy the effects of on performance decrements vary with different styles. Synthesizing that systematically report style impact counteracting is crucial for theoretical applications. Objectives This review aims provide comprehensive systematic analysis styles in fatigue Additionally, mechanisms counteracts will be discussed. Methods A search was conducted across five databases—Web Science, PubMed, SCOPUS, SPORTDiscus via EBSCOhost, Psychological Behavioral Sciences Collection EBSCOhost—up November 18, 2023. The selected focused solely interventions, outcomes including subjective feelings physiological markers, behavioral Results Nine met predetermined criteria inclusion this review. types interventions include relaxing, exciting, personal preference music, all were associated decreased changes objective markers. Cognitive performance, particularly inhibition working memory tasks impaired countered relaxing exciting music. Exciting found decrease reaction time more effectively than tasks. marker steady-state visually evoked potential-based brain-computer interface (SSVEP-BCI) amplitude increased, confirming such arm-pointing, Yo-Yo intermittent test, 5 km time-trial, counteracted Conclusion Relaxing reducing mitigating decrements. Individuals engaged mentally demanding can concurrent or subsequent simultaneously listening without lyrics using during recovery from effective Personal motor control endurance Mentally fatigued individuals could apply listen it Future should specify examine genres, tempos, intensities role contexts work productivity, traffic accident risk, sports requires further investigation, along underlying mechanisms.
Язык: Английский
Процитировано
0