Selective head-and-neck cooling on biomarker levels and symptom rating following a boxing bout- protocol for an exploratory randomized trial DOI Creative Commons
Ali Al-Husseini, Yelverton Tegner, Kaj Blennow

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Abstract Background Head impacts are common in contact sports such as boxing and occur at times of elevated core body brain temperatures induced by the exercise. Following impact, temperature may lead to development exacerbated injury that can be monitored blood biomarkers. We hypothesized acute head-and-neck cooling, recently shown shorten return-to-play concussed ice hockey players, applied acutely following a bout is associated with an attenuated release biomarkers improved symptom rating. Methods The trial academically driven funded external hospital research funds. Young, healthy elite boxers ≥ 18 years old recruited. Prior to, immediately after competitive over 3x2 or 3x3 minutes, samples drawn. Boxers randomized intervention control management 1:1 allocation prior baseline testing. After initial post-fight sample drawn rating using concussion assessment tool-5 (SCAT-5) has been collected, receive either selective cooling for 45 min, routine management. number head counted all on match video recordings. In both groups, minutes post-bout sample, well 3 6 days post-fight. At time points sampling, symptoms (NOS) severity score (SSS) assessed part SCAT-5. primary endpoint difference biomarker levels (GFAP, NF-L, tau, UCH-L1, neuronal-specific enolase) between pre-intervention levels, those obtained SCAT-5 NOS SSS secondary endpoints. Discussion There no treatment available boxing-induced injury. Biomarkers surrogate yet objective marker injury, attenuate injury-related reduce attained during fight. Potentially, option bout. Trials registration ClinicalTrials.gov, ClinicalTrials.gov Identifier NCT06386484. Registered April 23, 2024.

Язык: Английский

Neurofilament light (NfL) concentrations in patients with epilepsy with recurrent isolated seizures: insights from a clinical cohort study DOI Creative Commons
Justina Dargvainiene,

Safa Sahaf,

Jeanette Franzenburg

и другие.

Seizure, Год журнала: 2024, Номер 121, С. 91 - 94

Опубликована: Авг. 5, 2024

To detect possible neuronal damage due to recurrent isolated seizures in patients with epilepsy a clinical routine setting.

Язык: Английский

Процитировано

1
Drivers of resting-state fMRI heterogeneity in traumatic brain injury across injury characteristics and imaging methods: a systematic review and semiquantitative analysis DOI Creative Commons

Alexander W. Kashou,

Daniel M. Frees,

Kaylee Kang

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 27, 2024

Traumatic brain injury (TBI) is common and costly. Although neuroimaging modalities such as resting-state functional MRI (rsfMRI) promise to differentiate injured from healthy brains prognosticate long-term outcomes, the field suffers heterogeneous findings. To assess whether this heterogeneity stems variability in TBI populations studied or imaging methods used, determine a consensus exists literature, we performed first systematic review of studies comparing rsfMRI connectivity (FC) patients with matched controls for seven canonical networks across severity, age, chronicity, population type, various methods. Searching PubMed, Web Science, Google Scholar, ScienceDirect, 1,105 manuscripts were identified, 50 fulfilling our criteria. Across these manuscripts, 179 comparisons reported between total 1,397 1,179 controls. Collapsing characteristics, methods, networks, there roughly equal significant null findings increased decreased differences reported. Whereas most factors did not explain mixed findings, stratifying severity separately, showed trend at higher severities greater chronicities TBI. Among methodological factors, more likely find when scans longer than 360 s, custom image processing pipelines kept their eyes open versus closed during scans. We offer guidelines address variability, focusing on aspects study design acquisition move toward reproducible results potential clinical translation.

Язык: Английский

Процитировано

0
Brain Expression Levels of Commonly Measured Blood Biomarkers of Neurological Damage Differ with Respect to Sex, Race, and Age DOI Creative Commons
Grant C. O’Connell, Christine G. Smothers, Jing Wang

и другие.

Neuroscience, Год журнала: 2024, Номер 551, С. 79 - 93

Опубликована: Май 16, 2024

It is increasingly evident that blood biomarkers have potential to improve the diagnosis and management of both acute chronic neurological disorders. The most well-studied candidates, arguably those with broadest utility, are proteins highly enriched in neural tissues released into circulation upon cellular damage. currently unknown how brain expression levels these influenced by demographic factors such as sex, race, age. Given source tissue abundance likely a key determinant observed during pathology, understanding influences important terms identifying clinical scenarios could produce diagnostic bias. In this study, we leveraged existing mRNA sequencing data originating from 2,642 normal specimens harvested 382 human donors examine variability genes which code for 28 candidate Existing mass spectrometry 26 additional separate was subsequently used tentatively assess whether transcriptional variance corresponding protein abundance. Genes associated several or emerging including neurofilament light chain (NfL), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1), neuron-specific enolase (NSE), synaptosomal-associated 25 (SNAP-25) exhibited significant differences respect many instances, align well provide mechanistic explanation previously reported levels.

Язык: Английский

Процитировано

0
UCH-L1 and GFAP: Efficient biomarkers for diagnosing traumatic brain injury DOI Creative Commons

Thangavel Lakshmipriya,

Subash C.B. Gopinath

Brain and Spine, Год журнала: 2024, Номер 4, С. 102913 - 102913

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Selective head-and-neck cooling on biomarker levels and symptom rating following a boxing bout- protocol for an exploratory randomized trial DOI Creative Commons
Ali Al-Husseini, Yelverton Tegner, Kaj Blennow

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Abstract Background Head impacts are common in contact sports such as boxing and occur at times of elevated core body brain temperatures induced by the exercise. Following impact, temperature may lead to development exacerbated injury that can be monitored blood biomarkers. We hypothesized acute head-and-neck cooling, recently shown shorten return-to-play concussed ice hockey players, applied acutely following a bout is associated with an attenuated release biomarkers improved symptom rating. Methods The trial academically driven funded external hospital research funds. Young, healthy elite boxers ≥ 18 years old recruited. Prior to, immediately after competitive over 3x2 or 3x3 minutes, samples drawn. Boxers randomized intervention control management 1:1 allocation prior baseline testing. After initial post-fight sample drawn rating using concussion assessment tool-5 (SCAT-5) has been collected, receive either selective cooling for 45 min, routine management. number head counted all on match video recordings. In both groups, minutes post-bout sample, well 3 6 days post-fight. At time points sampling, symptoms (NOS) severity score (SSS) assessed part SCAT-5. primary endpoint difference biomarker levels (GFAP, NF-L, tau, UCH-L1, neuronal-specific enolase) between pre-intervention levels, those obtained SCAT-5 NOS SSS secondary endpoints. Discussion There no treatment available boxing-induced injury. Biomarkers surrogate yet objective marker injury, attenuate injury-related reduce attained during fight. Potentially, option bout. Trials registration ClinicalTrials.gov, ClinicalTrials.gov Identifier NCT06386484. Registered April 23, 2024.

Язык: Английский

Процитировано

0