Lipid polymorphism of plant thylakoid membranes. The dynamic exchange model – facts and hypotheses DOI Creative Commons
Győző Garab,

Kinga Böde,

Ondřej Dlouhý

и другие.

Physiologia Plantarum, Год журнала: 2025, Номер 177(2)

Опубликована: Март 1, 2025

Abstract The light reactions of oxygenic photosynthesis are performed by protein complexes embedded in the lipid bilayer thylakoid membranes (TMs). Bilayers provide optimal conditions for build‐up proton motive force (pmf) and ATP synthesis. However, functional plant TMs, besides bilayer, contain an inverted hexagonal (H II ) phase isotropic phases, a polymorphism due to their major, non‐bilayer species, monogalactosyldiacylglycerol (MGDG). behavior TMs is explained within framework Dynamic Exchange Model (DEM), extension fluid‐mosaic model. DEM portrays as inclusions between photosynthetic supercomplexes – characterized compromised membrane impermeability restricted sizes inflicted segregation propensity molecules, safe‐guarding high density TMs. Isotropic phases mediate fusions associated with lumenal lipocalin‐like enzyme, violaxanthin de‐epoxidase. Stromal‐side proteins surrounded lipids give rise H phase. These features instigate experimentally testable hypotheses: (i) sub‐compartmentalization chloroplasts quasi‐autonomous energization synthesis each granum‐stroma TM assembly; (ii) generation utilization pmf depend on hydrated networks proton‐conducting pathways along surfaces rather than strict bilayer.

Язык: Английский

Rethinking the Classical Chemiosmotic Theory DOI
Sunil Nath

Biological Theory, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

3
Field guide to Nath’s research work on ATP synthesis and hydrolysis DOI Creative Commons

Victor Wray

Biosystems, Год журнала: 2025, Номер unknown, С. 105461 - 105461

Опубликована: Апрель 1, 2025

Adenosine triphosphate (ATP) is the universal biological energy source that participates in most prevalent chemical reactions all cell life through vital processes of oxidative phosphorylation (OXPHOS) and photosynthesis. Its synthesis utilisation an area basic research has seen significant progress over last three decades. A series Nath's publications 1990s culminated a detailed description molecular mechanism ATP FO F1 portions FOF1-ATP synthase which from transmembrane ion gradients are converted into F1. Subsequent papers provided thorough theoretical basis exploration validity new theory-named by other authors as torsional transduction two-ion theory coupling. Violation several physical laws previous theories have been dealt with considerable detail. In particular he reevaluated extensive literature on hydrolysis provides rigorously argued tri-site involving filled β-catalytic sites during F1/F1-ATPase. Numerous applications proposed throughout his work resulted four substantial dealing re-interpretation Warburg Effect cancer cells trilogy thermodynamics applied to problems comparative physiology, biochemistry ecology. Finally strict mathematical methods opened up approaches validate mechanistic events synthesis/hydrolysis. Here we provide field guide for easy access different aspects this body work.

Язык: Английский

Процитировано

1
Lateral proton transport induced by acoustic solitons propagating in lipid membranes DOI Creative Commons
Vasiliy N. Kadantsev, Alexey Goltsov

Russian Technological Journal, Год журнала: 2025, Номер 13(2), С. 111 - 120

Опубликована: Янв. 23, 2025

Objectives . The study of proton transport in membrane structures represents a significant technological task the development hydrogen energy as well fundamental problem bioenergetics. Investigation this field aims at finding out physical mechanisms fast meso-porous polymer electrolyte membranes, which serve electrochemical components fuel cells. objectives research bioenergetics are to elucidate molecular effective transmembrane channel proteins, along surface proton-conducting biological membranes. To investigate direct water-membrane interface, we developed model movement quasi-one-dimensional lateral domain multicomponent lipid Methods approach is based on collective excitations spreading membranes form acoustic solitons, represent regions local compression polar groups and structural defects hydrocarbon chains molecules. Results results modeling showed that interaction between an excess soliton leads being trapped by soliton, followed its moving soliton. was applied describe inner mitochondrial role coupling function complexes cell Conclusions demonstrated within can determine one factors affecting efficiency interphase boundaries. Further theoretical approaches, taking into account dynamic properties contribute bioenergetics, investigation characteristics proton-exchange for industry.

Язык: Английский

Процитировано

0
Lipid polymorphism of plant thylakoid membranes. The dynamic exchange model – facts and hypotheses DOI Creative Commons
Győző Garab,

Kinga Böde,

Ondřej Dlouhý

и другие.

Physiologia Plantarum, Год журнала: 2025, Номер 177(2)

Опубликована: Март 1, 2025

Abstract The light reactions of oxygenic photosynthesis are performed by protein complexes embedded in the lipid bilayer thylakoid membranes (TMs). Bilayers provide optimal conditions for build‐up proton motive force (pmf) and ATP synthesis. However, functional plant TMs, besides bilayer, contain an inverted hexagonal (H II ) phase isotropic phases, a polymorphism due to their major, non‐bilayer species, monogalactosyldiacylglycerol (MGDG). behavior TMs is explained within framework Dynamic Exchange Model (DEM), extension fluid‐mosaic model. DEM portrays as inclusions between photosynthetic supercomplexes – characterized compromised membrane impermeability restricted sizes inflicted segregation propensity molecules, safe‐guarding high density TMs. Isotropic phases mediate fusions associated with lumenal lipocalin‐like enzyme, violaxanthin de‐epoxidase. Stromal‐side proteins surrounded lipids give rise H phase. These features instigate experimentally testable hypotheses: (i) sub‐compartmentalization chloroplasts quasi‐autonomous energization synthesis each granum‐stroma TM assembly; (ii) generation utilization pmf depend on hydrated networks proton‐conducting pathways along surfaces rather than strict bilayer.

Язык: Английский

Процитировано

0