Nrf2: a dark horse in doxorubicin-induced cardiotoxicity

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Июль 26, 2023

Abstract Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven to be formidable obstacle. Numerous studies are currently devoted elucidating the pathological mechanisms underlying doxorubicin-induced cardiotoxicity. Nrf2 has always played crucial role in oxidative stress, but numerous demonstrated that it also plays vital part like cell death and inflammation. on associated with cardiotoxicity demonstrate this. Several drugs, natural synthetic compounds, as well small molecule RNAs been prevent by activating Nrf2. Consequently, this study emphasizes introduction of Nrf2, discusses cardiotoxicity, concludes summary therapeutic modalities targeting ameliorate highlighting potential value

Язык: Английский

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Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases

Redox Biology, Год журнала: 2024, Номер 70, С. 103077 - 103077

Опубликована: Фев. 11, 2024

Inflammatory diseases present a serious health challenge due to their widespread prevalence and the severe impact on patients' lives. In quest alleviate burden of these diseases, nuclear factor erythroid 2-related 2 (Nrf2) has emerged as pivotal player. As transcription intimately involved in cellular defense against metabolic oxidative stress, Nrf2's role modulating inflammatory responses immune cells garnered significant attention. Recent findings suggest that ability alter redox status underlies its regulatory effects responses. Our review delves into preclinical clinical evidence underscores complex influence Nrf2 activators cell phenotypes, particularly milieu. By offering detailed analysis different populations, we cast light potential shaping response towards more regulated state, mitigating adverse inflammation through modeling cells. Furthermore, explore innovative use nanoencapsulation techniques enhance delivery efficacy activators, potentially advancing treatment strategies for ailments. We hope this will stimulate development expansion Nrf2-targeted treatments could substantially improve outcomes patients suffering from broad range diseases.

Язык: Английский

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Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation

Antioxidants, Год журнала: 2024, Номер 13(10), С. 1256 - 1256

Опубликована: Окт. 17, 2024

Environmental pollution continues to increase with industrial development and has become a threat human health. Atmospheric particulate matter (PM) was designated as Group 1 carcinogen by the International Agency for Research on Cancer in 2013 is an emerging global environmental risk factor that major cause of death related cardiovascular respiratory diseases. PM complex composed highly reactive organic matter, chemicals, metal components, which mainly excessive production oxygen species (ROS) can lead DNA cell damage, endoplasmic reticulum stress, inflammatory responses, atherosclerosis, airway remodeling, contributing increased susceptibility exacerbation various diseases infections. effects health depending particle size, physical chemical characteristics, source, exposure period. smaller than 5 μm penetrate accumulate alveoli circulatory system, causing harmful skin, brain. In this review, we describe relationship mechanism ROS-mediated oxidative responses caused organs, well comprehensively discuss harmfulness PM.

Язык: Английский

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Metallothionein Alleviates Glutathione Depletion–Induced Oxidative Cardiomyopathy through CISD1-Dependent Regulation of Ferroptosis in Murine Hearts

American Journal Of Pathology, Год журнала: 2024, Номер 194(6), С. 912 - 926

Опубликована: Фев. 28, 2024

Язык: Английский

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NF-ĸB axis in diabetic neuropathy, cardiomyopathy and nephropathy: A roadmap from molecular intervention to therapeutic strategies

Heliyon, Год журнала: 2024, Номер 10(9), С. e29871 - e29871

Опубликована: Апрель 18, 2024

Diabetes mellitus (DM) is a metabolic illness defined by elevated blood glucose levels, mediating various tissue alterations, including the dysfunction of vital organs. can lead to many consequences that specifically affect brain, heart, and kidneys. These issues are known as neuropathy, cardiomyopathy, nephropathy, respectively. Inflammation acknowledged pivotal biological mechanism contributes development diabetes consequences. NF-κB modulates inflammation immune system at cellular level. Its abnormal regulation has been identified in several clinical situations, cancer, inflammatory bowel illnesses, cardiovascular diseases, Mellitus (DM). The purpose this review evaluate potential impact on complications associated with DM. Enhanced activity promotes inflammation, resulting harm compromised organ performance. Phytochemicals, which therapeutic molecules, potentially decline level, therefore alleviating progression problems correlated More importantly, be influenced factors, such TLR4 Highlighting these factors facilitate novel therapies future.

Язык: Английский

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Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 28, 2025

Diabetic kidney disease (DKD) is a prevalent complication of diabetes mellitus (DM), and its incidence increasing alongside the number cases. Effective treatment long-term management DKD present significant challenges; thus, deeper understanding pathogenesis essential to address this issue. Chronic inflammation abnormal cell death in closely associate with development. Recently, there has been considerable attention focused on immune infiltration into renal tissues inflammatory response’s role progression. Concurrently, ferroptosis—a novel form death—has emerged as critical factor pathogenesis, leading increased glomerular filtration permeability, proteinuria, tubular injury, interstitial fibrosis, other pathological processes. The cardiorenal benefits SGLT2 inhibitors (SGLT2-i) patients have demonstrated through numerous large clinical trials. Moreover, further exploratory experiments indicate these drugs may ameliorate serum urinary markers inflammation, such TNF-α, inhibit ferroptosis models. Consequently, investigating interplay between innate responses for guiding future drug This review presents an overview within context DKD, beginning core mechanisms delving potential roles We will also analyze how aberrant cells, molecules, signaling pathways contribute Finally, we discuss interactions responses, well targeted therapeutic agents, based current evidence. By analyzing immunity aim provide insights development area.

Язык: Английский

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Alleviation of albumin glycation-induced diabetic cardiomyopathy by L-Arginine: Insights into Nrf-2 signaling

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130478 - 130478

Опубликована: Фев. 29, 2024

Язык: Английский

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Diabetic peripheral neuropathy based on Schwann cell injury: mechanisms of cell death regulation and therapeutic perspectives

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Авг. 12, 2024

Diabetic peripheral neuropathy (DPN) is a complication of diabetes mellitus that lacks specific treatment, its high prevalence and disabling neuropathic pain greatly affects patients’ physical mental health. Schwann cells (SCs) are the major glial nervous system, which play an important role in various inflammatory metabolic neuropathies by providing nutritional support, wrapping axons promoting repair regeneration. Increasingly, glucose (HG) has been found to promote progression DPN pathogenesis targeting SCs death regulation, thus revealing molecular process programmed cell (PCD) disrupted link gain insight into DPN. This paper first review recent progress HG studies on apoptosis, autophagy, pyroptosis, ferroptosis necroptosis pathways SCs, points out crosstalk between PCDs related therapeutic perspectives, with aim new perspectives for deeper understanding mechanisms exploration effective targets.

Язык: Английский

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Afobazole alleviates streptozotocin-induced diabetic nephropathy in rats via hypoglycemic, antioxidant, anti-inflammatory, and anti-apoptotic properties: Role of the S1R/Nrf2 antioxidant axis

Life Sciences, Год журнала: 2025, Номер 363, С. 123410 - 123410

Опубликована: Янв. 20, 2025

Язык: Английский

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Targeting mTOR with curcumin: therapeutic implications for complex diseases

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 16, 2025

Язык: Английский

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