A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100282 - 100282

Опубликована: Авг. 30, 2024

Bone metastasis remains a clinical challenge and is still considered incurable. While nanoparticles-based drug delivery photothermal therapy (PTT) show promise in treating subcutaneous solid tumor, their therapeutic outcome bone limited, due to the inaccessibility of metastatic site complexity metastasis. Herein, we reported simple nanoplatform composed thermo-sensitive liposomes (TSL) gold nanorods (GNR) treat through improved chemotherapy combined with GNR-assisted PTT. Lipid combination TSL was firstly tailored regulate its stability under physiological condition as well sensitivity responding PTT-caused mild hyperthermia. The obtained loaded then GNR form unsophisticated incubation. Cell experiments revealed that upon near-infrared (NIR) irradiation, effectively inhibited viability migration ability tumor cells PTT, PTT-triggered release, PTT-augmented drug. In murine model metastasis, enabled effective for rapid release local NIR irradiation. Through killing rebalancing turnover osteoclasts osteoblasts, largely preserved structure pain relief survival extension. Inspired by simplicity acquirement treatment operation, strategy liposomes-based PTT greatly promising

Язык: Английский

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Non-invasive methods of monitoring Fe3O4 magnetic nanoparticle toxicity in human liver HepaRG cells using impedance biosensing and Coherent anti-Stokes Raman spectroscopic (CARS) microscopy

Toxicology Letters, Год журнала: 2024, Номер 394, С. 92 - 101

Опубликована: Фев. 28, 2024

Functionalized nanoparticles have been developed for use in nanomedicines treating life threatening diseases including various cancers. To ensure safe of these new nanoscale reagents, assays biocompatibility or cytotoxicity vitro using cell lines often serve as preliminary assessments prior to vivo animal testing. However, many were designed soluble, colourless materials and may not be suitable coloured, non-transparent nanoparticles. Moreover, are always representative mammalian organs vivo. In this work, we non-invasive impedance sensing methods with organotypic human liver HepaRG cells a model test the toxicity PEG-Fe3O4 magnetic We also Coherent anti-Stokes Raman Spectroscopic (CARS) microscopy monitor formation lipid droplets parameter adverse effect on model. The results compared two commercial testing kits (PrestoBlue ATP) cytotoxicity. suggested that can more realistic than while monitoring Fe3O4 circumventing uncertainties due colour assays. These play important roles scientists driving towards 3Rs principle – Replacement, Reduction Refinement.

Язык: Английский

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Polyethylenimine: an efficient carrier in cancer therapeutics

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 85 - 95

Опубликована: Янв. 1, 2024

Язык: Английский

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Multimodal probes for the detection of bone cancer-related disease in biological systems: Recent advances and future prospects

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 181, С. 118030 - 118030

Опубликована: Окт. 29, 2024

Язык: Английский

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