Methyltransferase‐Like 3‐Mediated N⁶‐Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis and Treatment of Bone Diseases

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(5)

Опубликована: Март 1, 2025

Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance possess a high mortality risk, thus representing substantial health threats. To mitigate these concerns, it is imperative to investigate novel mechanistic insights. Methyltransferase-like 3 (METTL3) pivotal in disorders by modulating gene expression via N6-methyladenosine (m6A) modifications on RNA, thereby impacting cellular processes. Although considerable research has elucidated METTL3's involvement diseases, systematic review essential summarise findings evaluate significance. This endeavours aggregate examine contemporary studies elucidate role bone its clinical implications. We propose that METTL3 constitutes risk mediating m6A both mRNAs non-coding RNAs, suggesting may serve as critical diagnostic biomarker target. In conclusion, this provides an extensive analysis correlation osteoarthritis, osteosarcoma, offering valuable perspectives extant serving reference for researchers engaged basic translational studies.

Язык: Английский

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Methyltransferase-like 3-mediated RNA N6-methyladenosine contributes to immune dysregulation: diagnostic biomarker and therapeutic target

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 24, 2025

Methyltransferase-like 3 (METTL3) plays a crucial role in post-transcriptional gene regulation. Substantial evidence links METTL3 to various immune dysfunctions, such as the suppression of antiviral immunity during viral infections and disruption tolerance conditions like autoimmune diseases, myeloid leukemia, skin cancers, anticancer immunotherapy. However, thorough review analysis this is currently missing, which limits understanding METTL3’s mechanisms significance dysfunctions. This aims elucidate roles these issues, highlighting its connections proposing new insights into modulation responses. Analysis results suggest that hampers immunity, worsens replication infection, disrupts tolerance; conversely, regulating enhances facilitates clearance. Moreover, clinical data corroborates findings, showing overexpression associated with increased susceptibility conditions. establishes theoretical basis for considering novel regulator, an important diagnostic biomarker, potential target treating

Язык: Английский

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Understanding how methyltransferase-like 3 functions in lung diseases: From pathogenesis to clinical application

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117421 - 117421

Опубликована: Сен. 6, 2024

Язык: Английский

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The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 2, 2024

Methyltransferase-like 3(METTL3), recognized as the primary N

Язык: Английский

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Regulatory Network of Methyltransferase-Like 3 in Stem Cells: Mechanisms and Medical Implications

Cell Transplantation, Год журнала: 2024, Номер 33

Опубликована: Янв. 1, 2024

Stem cells have the potential to replace defective in several human diseases by depending on their self-renewal and differentiation capacities that are controlled genes. Currently, exploring regulation mechanism for stem cell from perspective of methyltransferase-like 3 (METTL3)-mediated N 6 -methyladenosine modification has obtained great advance, which functions regulating target genes post-transcriptionally. However, reviews interpret regulatory network METTL3 still lacking. In this review, we systematically analyze available publications report role mechanisms cells, including embryonic pluripotent mesenchymal cancer cells. The analysis such suggests controls fates is indispensable maintaining its normal capacities. dysfunction induces various pathologies, particularly cancers. To sum up, review as a key regulator capacities, with further exploration translational clinical fields. conclusion, promotes understanding how provides valuable reference fundamental studies applications.

Язык: Английский

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Research Progress on the Mechanism and Clinical Characteristics of Obesity in Thyroid Cancer

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(11), С. 1428 - 1437

Опубликована: Янв. 1, 2024

Язык: Английский

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