Mechanisms of ferroptosis and glucagon-like peptide-1 receptor agonist in post-percutaneous coronary intervention restenosis

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Язык: Английский

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Glucagon-like Peptide 1 Receptor Agonists in Cardio-Oncology: Pathophysiology of Cardiometabolic Outcomes in Cancer Patients

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11299 - 11299

Опубликована: Окт. 21, 2024

Cancer patients, especially long cancer survivors, are exposed to several cardio-metabolic diseases, including diabetes, heart failure, and atherosclerosis, which increase their risk of cardiovascular mortality. Therapy with glucagon-like peptide 1 (GLP1) receptor agonists demonstrated beneficial effects, atherosclerosis failure prevention. Cardiovascular outcome trials (CVOTs) suggest that GLP-1 RA could exert cardiorenal benefits systemic anti-inflammatory effects in patients type-2 diabetes through the activation cAMP PI3K/AkT pathways inhibition NLRP-3 MyD88. In this narrative review, we highlight biochemical properties a deep analysis clinical preclinical evidence primary prevention cardiomyopathies. The overall picture review encourages study as potential strategy against atherosclerosis.

Язык: Английский

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Mitochondria-targeting therapeutic strategies for chronic kidney disease

Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116669 - 116669

Опубликована: Ноя. 1, 2024

Язык: Английский

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Roles of ferroptosis in the development of diabetic nephropathy

Journal of Zhejiang University (Medical Sciences), Год журнала: 2024, Номер 53(6), С. 708 - 714

Опубликована: Дек. 1, 2024

Diabetic nephropathy is a common microvascular complication of diabetes mellitus and one the main causes death in patients with mellitus. Ferroptosis newly discovered iron-dependent regulated cell death, which may contribute to pathogenesis development diabetic nephropathy. Adenosine monophosphate-activated protein kinase (AMPK)-mediated ferroptosis-related signaling pathways can slow down progression nephropathy, but excessive activation AMPK pathway induce cells undergo autophagic death. Activation mediated by nuclear factor-erythroid 2-related factor (Nrf) 2 heme oxygenase (HO)-1 inhibit ferroptosis alleviate However, regulatory effect HO-1 on bidirectional, HIF-1α/HO-1 lead intracellular iron overload ultimately promote ferroptosis. Transforming growth (TGF)-β1 accelerate lipid peroxidation down-regulating levels SLC7A11/GSH/GPX4. The exosome lncRNAs/circRNAs/miRNAs are also involved In addition, stimulator interferon gene (STING) novel promoter acyl-CoA synthetase long-chain family (ACSL) 1 this review, we focus roles through AMPK, Nrf2/HO-1, TGF-β exosomes, elaborate potential therapeutic target for

Язык: Английский

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Control of Mitochondrial Quality: A Promising Target for Diabetic Kidney Disease Treatment

Kidney International Reports, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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