Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management
Jinjin Pei,
Ranil Vikraman Kumarasamy,
Selvaraj Jayaraman
и другие.
Ageing Research Reviews,
Год журнала:
2025,
Номер
unknown, С. 102665 - 102665
Опубликована: Янв. 1, 2025
Язык: Английский
From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors
Critical Reviews in Clinical Laboratory Sciences,
Год журнала:
2025,
Номер
unknown, С. 1 - 30
Опубликована: Фев. 1, 2025
Monitoring
individuals'
laboratory
data
is
essential
for
assessing
their
health
status,
evaluating
the
effectiveness
of
treatments,
predicting
disease
prognosis
and
detecting
subclinical
conditions.
Currently,
monitoring
performed
intermittently,
measuring
serum,
plasma,
whole
blood,
urine
occasionally
other
body
fluids
at
predefined
time
intervals.
The
ideal
approach
entails
continuous
measurement
concentration
activity
biomolecules
in
all
fluids,
including
solid
tissues.
This
can
be
achieved
through
use
biosensors
strategically
placed
various
locations
on
human
where
measurements
are
required
monitoring.
High-tech
wearable
provide
an
ideal,
noninvasive,
esthetically
pleasing
solution
data.
However,
despite
significant
advances
biosensor
technology,
capacities
number
different
analytes
that
continuously
monitored
patients
not
yet
desired
level.
In
this
review,
we
conducted
a
literature
search
examined:
(i)
overview
background
personalized
medicine,
(ii)
used
individuals,
(iii)
types
methods
biomolecules,
(iv)
statistical
algorithms
analysis
interpretation
evaluation.
Язык: Английский
Simulation and Local Parametric Sensitivity Analysis of a Computational Model of Fructose Metabolism
Processes,
Год журнала:
2025,
Номер
13(1), С. 125 - 125
Опубликована: Янв. 6, 2025
This
research
utilized
a
mathematical
model
of
fructose
metabolism
within
the
CellDesigner
software
package
to
investigate
effects
varying
dietary
intake
on
fat
metabolism.
By
simulating
different
meal
patterns
with
levels
fructose,
provided
valuable
insights
into
relationship
between
consumption
and
hepatic
triglyceride
accumulation.
The
results
demonstrated
clear
correlation
increased
elevated
triglycerides.
Additionally,
local
parametric
sensitivity
analysis
identified
glyceraldehyde-3-phosphate
pyruvate
as
key
regulatory
factors
in
this
process.
Importantly,
accurately
simulated
changes
concentration
its
metabolites,
validating
predictive
capabilities.
These
findings
underscore
importance
systems
biology
elucidating
complex
mechanisms
underlying
nutrition-related
diseases.
integrating
computational
modeling
experimental
data,
researchers
can
gain
deeper
understanding
how
influence
metabolic
pathways
contribute
health
outcomes.
Ultimately,
holds
promise
enabling
personalized
nutrition
recommendations
tailored
individual
needs
genetic
predispositions.
Язык: Английский
Stimuli‐Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases
Small,
Год журнала:
2025,
Номер
21(9)
Опубликована: Янв. 22, 2025
Abstract
Nanomaterials
with
unparalleled
physical
and
chemical
attributes
have
become
a
cornerstone
in
the
field
of
nanomedicine
delivery.
These
materials
can
be
engineered
into
various
functionalized
nanocarriers,
which
focus
research.
Stimulus‐responsive
nanodrug
delivery
systems
(SRDDS)
stand
out
as
sophisticated
class
nanocarriers
that
release
drugs
response
to
environmental
cues.
Due
complex
pathogenesis
multifaceted
pathological
environment
nervous
system,
developing
accurate
effective
drug
therapy
low
side‐effects
is
formidable
task.
In
recent
years,
SRDDS
been
widely
used
treatment
neurological
diseases.
By
customizing
align
specific
microenvironment
system
tissues
or
external
stimulation,
efficacy
enhanced.
This
review
provides
an
in‐depth
look
at
characteristics
diseases
highlights
case
studies
tailored
treat
these
disorders
based
on
unique
stimulation
criteria
triggers.
Additionally,
this
comprehensive
overview
progress
future
prospects
technology
diseases,
providing
valuable
guidance
for
its
transition
from
fundamental
research
clinical
application.
Язык: Английский
Advancing clinical biochemistry: addressing gaps and driving future innovations
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 8, 2025
Modern
healthcare
depends
fundamentally
on
clinical
biochemistry
for
disease
diagnosis
and
therapeutic
guidance.
The
discipline
encounters
operational
constraints,
including
sampling
inefficiencies,
precision
limitations,
expansion
difficulties.
Recent
advancements
in
established
technologies,
such
as
mass
spectrometry
the
development
of
high-throughput
screening
point-of-care
are
revolutionizing
industry.
biosensor
technology
wearable
monitors
facilitate
continuous
health
tracking,
Artificial
Intelligence
(AI)/machine
learning
(ML)
applications
enhance
analytical
capabilities,
generating
predictive
insights
individualized
treatment
protocols.
However,
concerns
regarding
algorithmic
bias,
data
privacy,
lack
transparency
decision-making
(“black
box”
models),
over-reliance
automated
systems
pose
significant
challenges
that
must
be
addressed
responsible
AI
integration.
limitations
remain—substantial
implementation
expenses,
system
incompatibility
issues,
information
security
vulnerabilities
intersect
with
ethical
considerations
fairness
protected
information.
Addressing
these
demands
coordinated
efforts
between
clinicians,
scientists,
technical
specialists.
This
review
discusses
current
biochemistry,
explicitly
addressing
reference
intervals
barriers
to
implementing
innovative
biomarkers
medical
settings.
discussion
evaluates
how
advanced
technologies
multidisciplinary
collaboration
can
overcome
constraints
while
identifying
research
priorities
diagnostic
accessibility
better
delivery.
Язык: Английский
The Role of Proteomics and Genomics in the Development of Colorectal Cancer Diagnostic Tools and Potential New Treatments
ACS Pharmacology & Translational Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Diagnosis Based on Population Data versus Personalized Data: The Evolving Paradigm in Laboratory Medicine
Diagnostics,
Год журнала:
2024,
Номер
14(19), С. 2135 - 2135
Опубликована: Сен. 25, 2024
The
diagnosis
of
diseases
is
a
complex
process
involving
the
integration
multiple
parameters
obtained
from
various
sources,
including
laboratory
findings.
interpretation
data
inherently
comparative,
necessitating
reliable
references
for
accurate
assessment.
Different
types
references,
such
as
reference
intervals,
decision
limits,
action
and
change
values,
are
essential
tools
in
data.
Although
these
used
to
interpret
individual
data,
they
typically
derived
population
which
raises
concerns
about
their
reliability
consequently
accuracy
individuals’
critical
all
subsequent
steps
medical
practice,
making
estimate
priority.
For
more
precise
interpretation,
should
ideally
be
an
individual’s
own
rather
than
averages.
This
manuscript
summarizes
current
sources
examines
themselves,
discusses
transition
population-based
medicine
personalized
medicine.
Язык: Английский