Cr(vi) permanently binds to the lipid bilayer in an inverted hexagonal phase throughout the reduction process DOI Creative Commons
Michał Nowakowski, Anna Wiśniewska-Becker, Joanna Czapla–Masztafiak

и другие.

RSC Advances, Год журнала: 2023, Номер 13(27), С. 18854 - 18863

Опубликована: Янв. 1, 2023

Cr(vi) is a harmful, carcinogenic agent with high permeability rate throughout the lipid membranes. In an intracellular environment and during interactions cellular membranes, it undergoes instant reduction to lower oxidation states radical states, recognized as most dangerous factor for cells. The membrane visible organelle in interior exterior of cell. this study, liposomes non-lamellar inverted hexagonal phase structures based on phosphoethanolamine (PE) were used model bilayers because their simple composition, preparation procedure, many other properties natural systems. membranes subjected 0.075 mM 15 min, after which Cr content was removed via dialysis. This way, remaining could be studied qualitatively quantitatively. Using combined XRF/XAS/EPR approach, we revealed that some (Cr(iii) Cr(vi)) still present samples even long-term dialysis at temperature significantly above transition chosen liposome. amount bound increased increasing PE -C[double bond, length m-dash]C- bond mixtures. Internal order decreased less fluid while more liquified ones, internal only slightly changed subjecting them agent. results suggest much sensitive than lamellar phase, can play important role strong cytotoxicity Cr(vi).

Язык: Английский

Sterol and lipid metabolism in bees DOI Creative Commons
Samuel Furse, Hauke Koch, Geraldine A. Wright

и другие.

Metabolomics, Год журнала: 2023, Номер 19(9)

Опубликована: Авг. 29, 2023

Abstract Background Bees provide essential pollination services for many food crops and are critical in supporting wild plant diversity. However, the dietary landscape of pollen sources social solitary bees has changed because agricultural intensification habitat loss. For this reason, understanding basic nutrient metabolism meeting nutritional needs is becoming an urgent requirement agriculture conservation. We know that principal source fat sterols pollinators, but a precise what nutrients how much needed not yet clear. Sterols key producing hormones control development may be present cell membranes, where fatty-acid-containing species important structural signalling molecules (phospholipids) or to supply, store distribute energy (glycerides). Aim review In review, we examine current general sterol lipid from variety literature discuss implications bee health. Key scientific concepts found while eusocial resilient some variation supply scope limited. The evidence both de novo lipogenesis need particular fatty acids (FAs) shows FA insects analogous mammals with distinct features. rely on their intake lipids way dependent upon availability.

Язык: Английский

Процитировано

10
Systemic analysis of lipid metabolism from individuals to multi-organism systems DOI Creative Commons
Samuel Furse, Carlos Martel, David F. Willer

и другие.

Molecular Omics, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Complete pipeline for system-level of biological systems, from indivituals to ecosystems, using only metabolite data.

Язык: Английский

Процитировано

4
Alterations in phosphatidylethanolamine metabolism impacts hepatocellular lipid storage, energy homeostasis, and proliferation DOI Creative Commons

Courtney M Holdaway,

Kelly‐Ann Leonard,

Randal C. Nelson

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2025, Номер unknown, С. 159608 - 159608

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Temporal oscillation of phospholipids promotes metabolic efficiency DOI
Sen Yang, Yuan Wang, Huang Sisi

и другие.

Nature Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Lipidomic and transcriptomic analysis reveals the self-regulation mechanism of Schizochytrium sp. in response to temperature stresses DOI

Xuechao Hu,

Yangyang Luo,

Yanli Man

и другие.

Algal Research, Год журнала: 2022, Номер 64, С. 102664 - 102664

Опубликована: Март 21, 2022

Язык: Английский

Процитировано

12
A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies DOI Creative Commons
Samuel Furse, Huw E. L. Williams, Adam J. Watkins

и другие.

Analytical and Bioanalytical Chemistry, Год журнала: 2021, Номер 413(19), С. 4763 - 4773

Опубликована: Июль 12, 2021

Abstract Detailed molecular analysis is of increasing importance in research into the regulation biochemical pathways, organismal growth and disease. Lipidomics particular increasingly sought after as it provides insight species involved energy storage, signalling fundamental cellular structures. This has led to use a range tools techniques acquire lipidomics data. 31 P NMR for offers well-resolved head group/lipid class analysis, structural data that can be used inform strengthen interpretation mass spectrometry part priori determination. In present study, we codify studies make technique more accessible new users useful wider questions. The isolation (phospholipidomics) or determining lipid composition (lipidomics). We describe process from sample extraction processing analysis. pipeline important because allows greater thoroughness increases scope answering scientific questions about lipid-containing systems.

Язык: Английский

Процитировано

13
Short Linear Motifs Orchestrate Functioning of Human Proteins during Embryonic Development, Redox Regulation, and Cancer DOI Creative Commons
Susanna S. Sologova, S. P. Zavadskiy, Innokenty M. Mokhosoev

и другие.

Metabolites, Год журнала: 2022, Номер 12(5), С. 464 - 464

Опубликована: Май 21, 2022

Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins that represent amino acid stretches composed 3 to 10 residues. The biological activities two short peptide segments human alpha-fetoprotein (AFP), a major embryo-specific and cancer-related protein, have been confirmed experimentally. This is heptapeptide segment LDSYQCT in domain I designated as AFP14-20 nonapeptide EMTPVNPGV III GIP-9. In our work, we searched the UniprotKB database for contain SLiMs with sequence similarity both AFP undertook gene ontology (GO)-based categorization retrieved proteins. Gene set enrichment analysis included GO terms process, molecular function, metabolic pathway, KEGG protein-protein interaction (PPI) categories. We identified interest variety non-homologous involved multiple cellular processes underlying embryonic development, cancer progression, and, unexpectedly, regulation redox homeostasis. These transcription factors, cell adhesion proteins, ubiquitin-activating conjugating enzymes, signaling oxidoreductase enzymes. They function by regulating proliferation differentiation, cycle, DNA replication/repair/recombination, metabolism, immune/inflammatory response, apoptosis. addition genes, new interacting genes were identified. Our data support hypothesis incorporated into serve blocks their orchestrated functioning.

Язык: Английский

Процитировано

7
Changes in glycosyl inositol phosphoceramides during the cell cycle of the red alga Galdieria sulphuraria DOI
Milada Vítová, Mária Čížková, Vít Náhlík

и другие.

Phytochemistry, Год журнала: 2021, Номер 194, С. 113025 - 113025

Опубликована: Ноя. 25, 2021

Язык: Английский

Процитировано

4
Boosting concurrent lipid accumulation and secretion by Coccomyxa subellipsoidea with glucose coupling glycerol as accelerator DOI
Yuqin Li,

Zhenhua Qi,

Yiwen Fan

и другие.

Algal Research, Год журнала: 2022, Номер 67, С. 102838 - 102838

Опубликована: Сен. 1, 2022

Язык: Английский

Процитировано

2
Cr(vi) permanently binds to the lipid bilayer in an inverted hexagonal phase throughout the reduction process DOI Creative Commons
Michał Nowakowski, Anna Wiśniewska-Becker, Joanna Czapla–Masztafiak

и другие.

RSC Advances, Год журнала: 2023, Номер 13(27), С. 18854 - 18863

Опубликована: Янв. 1, 2023

Cr(vi) is a harmful, carcinogenic agent with high permeability rate throughout the lipid membranes. In an intracellular environment and during interactions cellular membranes, it undergoes instant reduction to lower oxidation states radical states, recognized as most dangerous factor for cells. The membrane visible organelle in interior exterior of cell. this study, liposomes non-lamellar inverted hexagonal phase structures based on phosphoethanolamine (PE) were used model bilayers because their simple composition, preparation procedure, many other properties natural systems. membranes subjected 0.075 mM 15 min, after which Cr content was removed via dialysis. This way, remaining could be studied qualitatively quantitatively. Using combined XRF/XAS/EPR approach, we revealed that some (Cr(iii) Cr(vi)) still present samples even long-term dialysis at temperature significantly above transition chosen liposome. amount bound increased increasing PE -C[double bond, length m-dash]C- bond mixtures. Internal order decreased less fluid while more liquified ones, internal only slightly changed subjecting them agent. results suggest much sensitive than lamellar phase, can play important role strong cytotoxicity Cr(vi).

Язык: Английский

Процитировано

0