The Yin and Yang of hsa-miR-1244 expression levels during activation of the UPR control cell fate DOI Creative Commons

Paulina Czechowicz,

Magdalena Gebert, Sylwia Bartoszewska

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 2, 2024

Abstract Regulation of endoplasmic reticulum (ER) homeostasis plays a critical role in maintaining cell survival. When ER stress occurs, network three pathways called the unfolded protein response (UPR) is activated to reestablish homeostasis. While it known that there cross-talk between these pathways, how this complex regulated not entirely clear. Using human cancer and non-cancer lines, two different genome-wide approaches, models, we searched for miRNAs were decreased during UPR surprisingly found only one, miR-1244, was under all conditions. We also verified ER-stress related downregulation miR-1244 expression occurred with 5 stressors confirmed another line (HeLa S3). These analyses demonstrated outcome reduction supported both IRE1 signaling elevated BIP expression. Further analysis using inhibitors specific IRE1, ATF6, PERK revealed miRNA impacted by UPR. This first example mechanism which serves as regulatory check point 3 switched off activation. In summary, results indicate contributes pro-survival arm

Язык: Английский

The UPRising connection between endoplasmic reticulum stress and the tumor microenvironment DOI
Hery Urra,

Raúl Aravena,

Lucas González-Johnson

и другие.

Trends in cancer, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

8
Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine DOI Creative Commons
Lilian Calderón‐Garcidueñas, Angélica González-Maciel, Rafael Reynoso-Robles

и другие.

Toxics, Год журнала: 2025, Номер 13(3), С. 178 - 178

Опубликована: Фев. 28, 2025

Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.

Язык: Английский

Процитировано

0
Tools to Dissect Lipid Droplet Regulation, Players, and Mechanisms DOI Creative Commons

Jinmin Liu,

Yimon Aye

ACS Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Spurred by the authors' own recent discovery of reactive metabolite-regulated nexuses involving lipid droplets (LDs), this perspective discusses latest knowledge and multifaceted approaches toward deconstructing function these dynamic organelles, LD-associated localized signaling networks, protein players. Despite accumulating surrounding families pathways conserved importance for LD homeostasis surveillance maintenance across taxa, much remains to be understood at molecular level. In particular, metabolic stress-triggered contextual changes in LD-proteins' functions, crosstalk with other feedback loops how are specifically rewired disease states remain illuminated spatiotemporal precision. We hope promotes an increased interest essential organelles innovations new tools strategies better understand context-specific regulation critical organismal health.

Язык: Английский

Процитировано

0
Old drugs, new challenges: reassigning drugs for cancer therapies DOI Creative Commons

Paulina Czechowicz,

Anna Więch-Walów,

Jakub Sławski

и другие.

Cellular & Molecular Biology Letters, Год журнала: 2025, Номер 30(1)

Опубликована: Март 5, 2025

The "War on Cancer" began with the National Cancer Act of 1971 and despite more than 50 years effort numerous successes, there still remains much work to be done. major challenge complexity intrinsic polygenicity neoplastic diseases. Furthermore, safety antitumor therapies a concern given their often off-target effects. Although amount money invested in research development required introduce novel FDA-approved drug has continuously increased, likelihood for new cancer drug's approval limited. One interesting alternative approach, however, is idea repurposing old drugs, which both faster less costly developing drugs. Repurposed drugs have potential address shortage added benefit that concerns are already established. That being said, interactions other combination therapies, should tested. In this review, we discuss history repurposed some successes failures, as well multiple challenges obstacles need addressed order enhance drugs' therapies.

Язык: Английский

Процитировано

0
Pharmacological landscape of endoplasmic reticulum stress: uncovering therapeutic avenues for metabolic diseases DOI
Ghallab Alotaibi,

Abdullah Alkhammash

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177509 - 177509

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Neuroprotection vs. Neurotoxicity: The Dual Impact of Brain Lipids in Depression DOI Open Access
Yuting Yan, Yan Zhang, Mengting Liu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2722 - 2722

Опубликована: Март 18, 2025

Growing neurochemical evidence highlights cerebral lipid dysregulation as a key factor in the pathophysiology of major depressive disorder (MDD). This review systematically explores dual roles species both normal behavioral regulation and MDD development. By critically examining recent literature, we classify these into two functional categories based on their neuroactivity: (1) neuroprotective lipids (sphingomyelin, cholesterol, cardiolipin, sphingosine, phosphatidic acid, phosphatidylserine), which exert effects by modulating membrane fluidity supporting synaptic vesicle trafficking; (2) neurotoxic (ceramides, phosphatidylinositol, phosphocholine, phosphatidylethanolamine), promote apoptotic signaling cascades disrupt mitochondrial bioenergetics. An unresolved but critical question pertains to maintenance homeostatic equilibrium between opposing classes. balance is essential, given significant impact protein localization function, monoaminergic neurotransmitter metabolism, energy homeostasis, redox neural circuits involved mood regulation. emerging framework positions lipidomics promising avenue for identifying novel therapeutic targets developing biomarker-based diagnostic approaches treatment.

Язык: Английский

Процитировано

0
The Yin and Yang of hsa-miR-1244 expression levels during activation of the UPR control cell fate DOI Creative Commons

Paulina Czechowicz,

Magdalena Gebert, Sylwia Bartoszewska

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 2, 2024

Abstract Regulation of endoplasmic reticulum (ER) homeostasis plays a critical role in maintaining cell survival. When ER stress occurs, network three pathways called the unfolded protein response (UPR) is activated to reestablish homeostasis. While it known that there cross-talk between these pathways, how this complex regulated not entirely clear. Using human cancer and non-cancer lines, two different genome-wide approaches, models, we searched for miRNAs were decreased during UPR surprisingly found only one, miR-1244, was under all conditions. We also verified ER-stress related downregulation miR-1244 expression occurred with 5 stressors confirmed another line (HeLa S3). These analyses demonstrated outcome reduction supported both IRE1 signaling elevated BIP expression. Further analysis using inhibitors specific IRE1, ATF6, PERK revealed miRNA impacted by UPR. This first example mechanism which serves as regulatory check point 3 switched off activation. In summary, results indicate contributes pro-survival arm

Язык: Английский

Процитировано

1