Biomolecules, Год журнала: 2024, Номер 14(11), С. 1365 - 1365
Опубликована: Окт. 27, 2024
Fibrogenesis is a physiological process required for wound healing and tissue repair. It induced by activation of quiescent fibroblasts, which first proliferate then change their phenotype into migratory, contractile myofibroblasts. Myofibroblasts secrete extracellular matrix proteins, such as collagen, to form scar. Once the terminated, most myofibroblasts undergo apoptosis. However, in some tissues, heart, remain active sensitive neurohumoral factors inflammatory mediators, lead eventually excessive organ fibrosis. Many cellular processes involved fibroblast activation, including cell proliferation, protein secretion contraction, are highly regulated intracellular Ca
Язык: Английский