Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects DOI Creative Commons

Yang Hao,

Chu Zhong,

Shuwen Han

и другие.

Cell Proliferation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

ABSTRACT Membraneless organelles (MLOs) are a type of subcellular compartment structure discovered in eukaryotes recent years. They mainly formed through the liquid–liquid phase separation (LLPS) and aggregation macromolecular substances such as proteins or nucleic acids cells. When cells stimulated, they initiate series stress responses including gene transcription, RNA metabolism, translation, protein modification signal transduction to maintain homeostasis. The dysregulation these cellular processes is key event occurrence development cancer. This article provides an overview function membraneless organelles, well mechanisms separation, summarise latest research progress on tumours. It focuses role molecular mechanism LLPS tumours, with aim providing new theoretical references for developing drug action targets innovative treatment strategies.

Язык: Английский

Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects DOI Creative Commons

Yang Hao,

Chu Zhong,

Shuwen Han

и другие.

Cell Proliferation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

ABSTRACT Membraneless organelles (MLOs) are a type of subcellular compartment structure discovered in eukaryotes recent years. They mainly formed through the liquid–liquid phase separation (LLPS) and aggregation macromolecular substances such as proteins or nucleic acids cells. When cells stimulated, they initiate series stress responses including gene transcription, RNA metabolism, translation, protein modification signal transduction to maintain homeostasis. The dysregulation these cellular processes is key event occurrence development cancer. This article provides an overview function membraneless organelles, well mechanisms separation, summarise latest research progress on tumours. It focuses role molecular mechanism LLPS tumours, with aim providing new theoretical references for developing drug action targets innovative treatment strategies.

Язык: Английский

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