SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

Brain Behavior and Immunity, Год журнала: 2021, Номер 100, С. 267 - 277

Опубликована: Дек. 13, 2021

Язык: Английский

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Psychiatric and neurological complications of long COVID

Journal of Psychiatric Research, Год журнала: 2022, Номер 156, С. 349 - 360

Опубликована: Окт. 20, 2022

Язык: Английский

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Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Current Neuropharmacology, Год журнала: 2023, Номер 22(4), С. 557 - 635

Опубликована: Май 3, 2023

Abstract: This narrative state-of-the-art review paper describes the progress in understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over last four decades, scientific landscape has matured, with many interdisciplinary contributions to its diagnosis, etiology, epidemiology. Advances genetics, neurobiology, stress pathophysiology, brain imaging have made it apparent that chronic PTSD is a systemic disorder high allostatic load. The current state includes wide variety pharmacological psychotherapeutic approaches, which are evidence-based. However, myriad challenges inherent disorder, such as individual barriers good outcome, comorbidity, emotional dysregulation, suicidality, dissociation, substance use, trauma-related guilt shame, often render response suboptimal. These discussed drivers for emerging novel including early interventions Golden Hours, interventions, medication augmentation use psychedelics, well targeting nervous system. All this aims improve symptom relief clinical outcomes. Finally, phase orientation recognized tool strategize position step progression pathophysiology. Revisions guidelines systems care will be needed incorporate innovative treatments evidence emerges they become mainstream. generation well-positioned address devastating disabling impact traumatic events through holistic, cutting-edge efforts research.

Язык: Английский

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Neuropsychiatric aspects of long COVID: A comprehensive review

Psychiatry and Clinical Neurosciences, Год журнала: 2022, Номер 77(2), С. 84 - 93

Опубликована: Ноя. 17, 2022

Although some patients have persistent symptoms or develop new following coronavirus disease 2019 (COVID-19) infection, neuropsychiatric aspects of long COVID are not well known. This review summarizes and provides an update on the dimensions COVID. Its manifestations commonly include fatigue, cognitive impairment, sleep disorders, depression, anxiety, post-traumatic stress disorder. There no specific tests for COVID, but characteristic findings such as hypometabolism positron emission tomography been reported. The possible mechanisms inflammation, ischemic effects, direct viral invasion, social environmental changes. Some patient characteristics severity complications acute COVID-19 infection may be associated with increased risk symptoms. Long resolve spontaneously persist, depending type established treatments lacking, various psychological pharmacological attempted. Vaccination against plays a key role in prevention disease. With differences among SARS-CoV-2 variants, including omicron variant, likely to change future. Further studies clarifying effective warranted.

Язык: Английский

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Long COVID and neuropsychiatric manifestations (Review)

Experimental and Therapeutic Medicine, Год журнала: 2022, Номер 23(5)

Опубликована: Апрель 1, 2022

There is accumulating evidence in the literature indicating that a number of patients with coronavirus disease 2019 (COVID‑19) may experience range neuropsychiatric symptoms, persisting or even presenting following resolution acute COVID‑19. Among manifestations more frequently associated 'long COVID' are depression, anxiety, post‑traumatic stress disorder, sleep disturbances, fatigue and cognitive deficits, can potentially be debilitating negatively affect patients' wellbeing, albeit majority cases symptoms tend to improve over time. Despite variations results obtained from studies using different methodological approaches define syndrome, most widely accepted factors higher risk developing include severity foregoing COVID‑19, female sex, presence comorbidities, history mental health an elevation levels inflammatory markers, further research required establish causal associations. To date, pathophysiological mechanisms implicated remain only partially elucidated, while role indirect effects COVID‑19 pandemic, such as social isolation uncertainty concerning social, financial recovery post‑COVID, have also been highlighted. Given alarming 'long‑COVID', interdisciplinary cooperation for early identification who at high persistent presentations, beyond recovery, crucial ensure appropriate integrated physical support provided, aim mitigating risks long‑term disability societal individual level.

Язык: Английский

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A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Июль 21, 2022

A considerable number of individuals infected with SARS-CoV-2 continue to experience symptoms after the acute phase. Here, we report findings from a nationwide questionnaire study in Denmark including 61,002 RT-PCR confirmed cases and 91,878 test-negative controls aged 15-years or older. Six twelve months test, risks 18 out 21 were elevated among test-positives. The largest adjusted risk differences (RD) observed for dysosmia (RD = 10.92%, 95% CI 10.68-11.21%), dysgeusia 8.68%, 8.43-8.93%), fatigue/exhaustion 8.43%, 95%CI 8.14-8.74%), dyspnea 4.87%, 4.65-5.09%) reduced strength arms/legs 4.68%, 4.45-4.89%). During period test until completion questionnaire, new diagnoses anxiety 1.15%, 0.95-1.34%) depression 1.00%, 0.81-1.19%) also more common Even population where majority test-positives not hospitalized, proportion experiences up 12 infection. Being female middle-aged increases risks.

Язык: Английский

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The emotional well-being of Long COVID patients in relation to their symptoms, social support and stigmatization in social and health services: a qualitative study

BMC Psychiatry, Год журнала: 2023, Номер 23(1)

Опубликована: Янв. 25, 2023

Long COVID patients have experienced a decline in their quality of life due to, part but not wholly, its negative emotional impact. Some the most prevalent mental health symptoms presented by long are anxiety, depression, and sleep disorders. As such, need has arisen to analyze personal experiences these understand how they managing daily lives while dealing with condition. The objective this study is increase understanding about well-being people diagnosed COVID.

Язык: Английский

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The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 6, 2024

Post COVID-19 syndrome, also known as "Long COVID," is a complex and multifaceted condition that affects individuals who have recovered from SARS-CoV-2 infection. This systematic review meta-analysis aim to comprehensively assess the global prevalence of depression, anxiety, sleep disorder in coping with syndrome.

Язык: Английский

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Role of SARS-CoV-2 Spike-Protein-Induced Activation of Microglia and Mast Cells in the Pathogenesis of Neuro-COVID

Cells, Год журнала: 2023, Номер 12(5), С. 688 - 688

Опубликована: Фев. 22, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a few months after the initial infection and develop post-acute sequelae SARS-CoV-2 (PASC), referred to as “Long-COVID,” characterized by persistent physical mental fatigue. However, exact pathogenetic mechanisms affecting brain are still not well-understood. There is increasing evidence neurovascular inflammation in brain. precise role neuroinflammatory response that contributes severity long COVID pathogenesis clearly understood. Here, we review reports spike protein can cause blood–brain barrier (BBB) dysfunction damage neurons either directly, or via activation mast cells microglia release various molecules. Moreover, provide recent novel flavanol eriodictyol particularly suited for development an effective treatment alone together with oleuropein sulforaphane (ViralProtek®), all which have potent anti-viral anti-inflammatory actions.

Язык: Английский

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Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Work, Год журнала: 2023, Номер 74(4), С. 1179 - 1186

Опубликована: Март 10, 2023

BACKGROUND: Long COVID describes a condition with symptoms that linger for months to years following acute COVID-19. Many of these are like those experienced by patients myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). OBJECTIVE: We wanted determine if people post-exertional malaise (PEM), the hallmark symptom ME/CFS, and so, how it compared PEM ME/CFS. METHODS: A questionnaire asked about domains including triggers, experience, recovery, prevention was administered 80 seeking care at Bateman Horne Center. Their responses were given 151 ME/CFS using chi-square tests independence. RESULTS: All but one respondent reported having PEM. There many significant differences in types during PEM, ways recover prevent between Similarities included low medium physical cognitive exertion trigger fatigue, pain, immune reaction, neurologic, orthostatic intolerance, gastrointestinal rest from pacing CONCLUSION: People experience This may be due newness COVID, not knowing what exertional intolerance is or manage it.

Язык: Английский

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