Mapping acute neuroinflammation in vivo with diffusion-MRI in rats given a systemic lipopolysaccharide challenge

Brain Behavior and Immunity, Год журнала: 2023, Номер 113, С. 289 - 301

Опубликована: Июль 21, 2023

It is becoming increasingly apparent that neuroinflammation plays a critical role in an array of neurological and psychiatric disorders. Recent studies have demonstrated the potential diffusion MRI (dMRI) to characterize changes microglial density morphology associated with neuroinflammation, but these were conducted mostly ex vivo and/or extreme, non-physiological animal models. Here, we build upon by investigating utility well-established dMRI methods detect more clinically relevant model sickness behavior. We show tensor imaging (DTI) neurite orientation dispersion (NODDI) indicate widespread increases diffusivity brains rats given systemic lipopolysaccharide challenge (n = 20) vs. vehicle-treated controls 12). These correlated histologically measured morphology, confirming sensitivity neuroinflammatory processes. This study marks further step towards establishing noninvasive indicator which would greatly facilitate early diagnosis treatment monitoring various diseases.

Язык: Английский

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Brain ventricle and choroid plexus morphology as predictor of treatment response in major depression: Findings from the EMBARC study

Brain Behavior & Immunity - Health, Год журнала: 2023, Номер 35, С. 100717 - 100717

Опубликована: Дек. 20, 2023

Recent observations suggest a role of the volume cerebral ventricle volume, corpus callosum (CC) segment in particular that central-anterior part, and choroid plexus (CP) for treatment resistance major depressive disorder (MDD). An increased CP has been associated with inflammatory activity changes structure ventricles callosum. We attempt to replicate confirm these imaging markers are clinical outcome subjects from EMBARC study, as implied by recent pilot study. The study is placebo controlled randomized comparing sertraline vs. patients MDD identify biological therapy resistance. Association baseline volumes lateral (LVV), (CPV) segments CC response after 4 weeks was evaluated. 171 (61 male, 110 female) completed week assessments; gender age were taken into account this analyses. As previously reported, no effect observed, therefore characterized prognostic pooled population. Change depression severity identified ratio Hamilton-Depression rating scale 17 (HAMD-17) at divided HAMD-17 (HAMD-17 ratio). Volumes plexi positively correlated ratio, indication worse larger volumes, whereas negatively ratio. Responders (n = 54) had significantly smaller compared non-responders 117), mid-anterior confirming our previous findings. In an exploratory way associations between enlarged LVV CPV signs lipid dysregulation observed. conclusion, we confirmed ventricles, improvement may be indicators metabolic/inflammatory activity.

Язык: Английский

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Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression

Brain, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

Although both central and peripheral inflammation have been observed consistently in depression, the relationship between two remains obscure. Extra-axial immune cells may play a role mediating connection immunity. This study investigates potential roles of calvarial bone marrow parameningeal spaces interactions immunity depression. PET was used to measure regional TSPO expression skull parameninges as marker inflammatory activity. correlated with brain cytokine concentrations cohort enriched for heightened comprising 51 individuals depression 25 healthy controls. The findings reveal complex Facial parietal showed significant associations confluence sinuses also linked markers. Group-dependent elevations within occipital were found be significantly associated inflammation. Significant activity skull, parameninges, parenchyma periphery highlight venous pivotal sites interactions.

Язык: Английский

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The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Март 6, 2025

Depression is common in people living with Inflammatory Bowel Disease (IBD). rates increase active disease and are linked to poorer clinical outcomes. Previous studies investigating the relationship between contemporaneous IBD activity depression often poorly controlled, use small samples and/or rely on self-reported measures of activity. (SRDA) increased healthcare usage, however, objective inflammation rarely statistically controlled. The primary aim was understand how related depression. Secondary aims included assessing relative influence activity, usage. This a cross-sectional analysis baseline data collected as part randomised controlled trial (trial registration no: ISRCTN71618461) digital treatment for symptom self-management (n = 599). Bivariate associations demographic variables were conducted identify relevant covariates. Multiple linear regressions assessed (i) relationships (Patient Health Questionnaire-9 (PHQ-9)), SRDA (IBD-Control) intestinal (faecal calprotectin (FCP)) (ii) whether these explained variance usage economic indicators. significantly predicted by (β -0.82, p < 0.001) but not FCP, model explaining 37% (F(2,596) 175.1, 0.001). FCP only weakly associated (r -0.16, independently visits care 0.19, 0.001), secondary 0.13, IBD-related A&E attendance 0.10 0.05) impact productivity 0.24 last 3 months. FCP. also even when Routinely treating alongside managing may improve symptoms patients reduce costs.

Язык: Английский

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Choroid plexus enlargement correlates with cognitive impairment and brain atrophy in patients with mood disorders

Journal of Affective Disorders, Год журнала: 2025, Номер 379, С. 370 - 378

Опубликована: Март 13, 2025

Язык: Английский

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Glymphatic function and choroid plexus volume is associated with systemic inflammation and oxidative stress in major depressive disorder

Brain Behavior and Immunity, Год журнала: 2025, Номер 128, С. 266 - 275

Опубликована: Апрель 11, 2025

Язык: Английский

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No relationship between inflammatory cytokines, heart rate variability, and morphology of the vagus nerves in patients with major depressive disorder

Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 101009 - 101009

Опубликована: Май 1, 2025

Язык: Английский

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Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship

Cancers, Год журнала: 2023, Номер 15(17), С. 4414 - 4414

Опубликована: Сен. 4, 2023

About one-in-three breast cancer survivors have lingering cognitive complaints and objective impairment. Chronic inflammation intestinal permeability (i.e., leaky gut), two risk factors for decline, can also fuel depression—another vulnerability decline. The current study tested whether depression accompanied by high levels of or predicted lower subjective function in survivors. We combined data from four survivor studies (n = 613); some had repeated measurements a total 1015 visits. All participants blood draw to obtain baseline measures lipopolysaccharide binding protein—a measure permeability, as well three inflammatory markers that were incorporated into an index: C-reactive protein, interleukin-6, tumor necrosis factor-α. They reported depressive symptoms on the Center Epidemiological Studies scale (CES-D), binary variable indicated clinically significant (CES-D ≥ 16). Kohli (749 observations) Breast Cancer Prevention Trial (591 scales assessed function. Objective tests included trail-making test, Hopkins verbal learning Conners continuous performance n-back FAS animal-naming test (239–246 observations). Adjusting education, age, BMI, treatment type, time since treatment, visit, fatigue, women who elevated heightened poorer focus marginally memory. However, across was not specific inflammation-associated depression. Rather, there evidence fluency; attention, memory, working memory; difficulties with visuospatial search among depressed survivors, regardless inflammation. By themselves, less consistently either may perceive greater difficulty, even though depression-related deficits be inflammation- leaky-gut-associated

Язык: Английский

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Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 13907 - 13907

Опубликована: Сен. 9, 2023

Major depressive disorder (MDD) is a highly prevalent psychiatric condition affecting an estimated 280 million individuals globally. Despite the occurrence of suicidal behaviors across various conditions, MDD distinctly associated with highest risk suicide attempts and death within this population. In study, we focused on to identify potential inflammatory biomarkers risk, given relationship between states ideation. Articles published before June 2023 were searched in PubMed, Embase, Web Science, Cochrane Library all relevant studies reporting blood patients suicide-related behaviors. Of 571 articles, 24 included study. Overall, 43 significant identified. Our study provided compelling evidence alterations peripheral factors behaviors, demonstrating roles interleukin (IL)-1β, IL-6, C-reactive protein, C-C motif chemokine ligand 2, tumor necrosis factor-α as biomarkers. These findings underscore intricate processes these their interactions risk.

Язык: Английский

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A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging

ACS Central Science, Год журнала: 2024, Номер 10(5), С. 1105 - 1114

Опубликована: Апрель 25, 2024

Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In central nervous system (CNS), COX-2 implicated neurodegenerative psychiatric disorders as potential therapeutic target biomarker. However, clinical studies with have yielded inconsistent results, partly due to limited mechanistic understanding of how activity relates CNS pathology. Therefore, developing positron emission tomography (PET) radiotracers for human neuroimaging interest. This study introduces [11C]BRD1158, which potent uniquely fast-binding, selective PET radiotracer. [11C]BRD1158 was developed by prioritizing potency at COX-2, isoform selectivity over COX-1, fast binding kinetics, free fraction brain. Evaluated through vivo rodent models overexpression, demonstrated high brain uptake, target-engagement, functional reversibility, excellent specific binding, advantageous imaging applications. Lastly, post-mortem samples from Huntington's disease (HD) patients preclinical HD mouse showed levels were elevated specifically disease-affected regions, primarily increased expression microglia. These findings indicate holds promise novel marker onset progression, one many applications PET.

Язык: Английский

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