Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 18, 2025

The tryptophan (TRP)-kynurenine (KYN) pathway is involved in the pathogenesis of schizophrenia. This study aimed to investigate levels TRP-KYN metabolites serum and urine patients with first-episode schizophrenia (FES) their association clinical manifestations. included 38 drug-naive FES 43 healthy controls (HCs). Clinical symptoms were evaluated using Positive Negative Syndrome Scale (PANSS). Levels quantified. Patients showed significantly higher quinolinic acid/kynurenic acid (QUIN/KYNA) ratio KYN/TRP compared HCs, while neuroprotective metabolites, including KYNA, xanthurenic (XA), picolinic (PIC) levels, reduced, along a decreased PIC/QUIN (p < 0.05). KYNA/KYN was negatively correlated PANSS general psychopathology scores (r = -0.35, p 0.04) total 0.046). exhibited dysregulation peripheral pathway, characterized by an increased neurotoxic-to-neuroprotective QUIN/KYNA reduced metabolites. shift towards neurotoxic product generation suggests that could play role pathophysiology

Язык: Английский

---

Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102250 - 102250

Опубликована: Фев. 26, 2024

Язык: Английский

---

The role of immune inflammation in electroconvulsive therapy for schizophrenia: Treatment mechanism, and relationship with clinical efficacy

Psychiatry Research, Год журнала: 2023, Номер 332, С. 115708 - 115708

Опубликована: Дек. 31, 2023

Язык: Английский

---

Cytokines as Predictors of Response to Electroconvulsive Therapy: an Update

Current Behavioral Neuroscience Reports, Год журнала: 2023, Номер 10(4), С. 99 - 109

Опубликована: Ноя. 8, 2023

Язык: Английский

---