Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls

Psychological Medicine, Год журнала: 2024, Номер unknown, С. 1 - 11

Опубликована: Окт. 2, 2024

Abstract Background While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) bipolar (BD) spectrum disorders. There however, limited knowledge about the longitudinal course this relationship. Methods Systemic (C-Reactive Protein, CRP) cognition (nine domains) was measured from baseline to 1 year follow-up first treatment SZ BD ( n = 221), healthy controls (HC, 220). Linear mixed models were used evaluate changes separately CRP domains specific diagnostic status (SZ, BD, HC). Hierarchical clustering applied on entire sample investigate inflammatory-cognitive subgroups. Results no case-control differences or change follow-up. We confirm previous observations at both time-points domain stability/improvement over time regardless status. identified differing demographics clinical severity. Despite improvement cognition, symptoms functioning, higher – lower subgroup (75% SZ; 48% BD; 38% HC) had sustained more symptoms, functioning (SMI only) This comparison a (25% SZ, 52% 62% HC), where SMI participants showed HC level positive course. Conclusions Our findings support heterogenous that are stable time, may benefit targeted interventions.

Язык: Английский

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Inflammation-related abnormal dynamic brain activity correlates with cognitive impairment in first-episode, drug-naïve major depressive disorder

Journal of Affective Disorders, Год журнала: 2024, Номер 366, С. 217 - 225

Опубликована: Авг. 27, 2024

Язык: Английский

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Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 3, 2023

Abstract Recent findings link cognitive impairment and inflammatory-immune dysregulation in schizophrenia (SZ) bipolar (BD) spectrum disorders. However, heterogeneity translation between the periphery central (blood-to-brain) mechanisms remains a challenge. Starting with large SZ, BD healthy control cohort ( n =1235), we aimed to i) identify candidate peripheral markers =25) associated domains =9) elucidate heterogenous immune-cognitive patterns, ii) evaluate regulation of using human induced pluripotent stem cell (iPSC)-derived astrocytes neural progenitor cells =10), iii) marker messenger RNA expression leukocytes microarray available data from subsample main =776), RNA-sequencing deconvolution analysis postmortem brain samples =474) CommonMind Consortium (CMC). We identified transdiagnostic subgroups based on covariance (measures speed verbal learning) reflecting inflammatory response (CRP, sTNFR1, YKL-40), innate immune activation (MIF) extracellular matrix remodelling (YKL-40, CatS). Of there was considerable variance secretion YKL-40 iPSC-derived SZ compared HC. Further, provide evidence dysregulated genes encoding related signalling pathways high subgroup consisting predominantly samples. Our suggest relationship activity impairment, highlight as potential functioning individuals severe mental illness.

Язык: Английский

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Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

Abstract Background While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) bipolar (BD) spectrum disorders. There however, limited knowledge about the longitudinal course this relationship. Methods Systemic (C-Reactive Protein, CRP) cognition (nine domains) was measured from baseline to 1 year follow-up first treatment SZ BD (n=221), healthy controls (HC, n=220). Linear mixed models were used evaluate changes separately CRP domains specific diagnostic status (SZ, BD, HC). Hierarchical clustering applied on entire sample investigate inflammatory-cognitive subgroups. Results no case-control differences or change follow-up. We confirm previous observations at both time-points domain stability/improvement over time regardless status. identified differing demographics clinical severity. Despite improvement cognition, symptoms functioning, higher – lower subgroup (75% SZ; 48% BD; 38% HC) had sustained more symptoms, functioning (SMI only) This comparison a (25% SZ, 52% 62% HC), where SMI participants showed HC level positive course. Conclusions Our findings support heterogenous that are stable time, may benefit targeted interventions.

Язык: Английский

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The psychoneuroimmunology of Psychosis: Peeking past the clouds of Heterogeneity: Editorial

Brain Behavior and Immunity, Год журнала: 2024, Номер 119, С. 709 - 712

Опубликована: Апрель 24, 2024

Язык: Английский

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