Genetically Confirmed Optimal Causal Association of Cerebrospinal Fluid Metabolites With Hemorrhagic Stroke
Journal of Neurochemistry,
Год журнала:
2025,
Номер
169(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Hemorrhagic
stroke
(HS)
mainly
includes
intracerebral
hemorrhage
(ICH)
and
subarachnoid
(SAH),
both
of
which
seriously
affect
the
patient's
prognosis.
Cerebrospinal
fluid
(CSF)
metabolites
HS
showed
a
link
in
observational
studies.
However,
causal
association
between
them
is
not
clear.
We
aimed
to
establish
optimal
causality
CSF
with
HS.
Mendelian
randomization
(MR)
was
employed
identify
associations
different
sources
Univariable
MR
false
discovery
rates
(FDR)
were
used
initial
associations.
Linkage
disequilibrium
score
regression
determined
genetic
correlations.
Multiple
sensitive
analyses
ensured
reliability
results.
Multivariable
Bayesian
Model
Averaging
The
combined
effects
assessed
by
meta‐analyses.
Pathway
performed
potential
pathways
action.
Reverse
also
conducted
reverse
Finally,
Corresponding
blood
explore
multiple
roles
metabolites.
identified
20
six
metabolic
associated
ICH;
15
three
SAH.
Nineteen
seven
causally
deep
lobar
ICH,
respectively.
levels
mannose
(OR
0.63;
95%
CI
0.45–0.88;
P
=
0.0059)
N
‐acetyltaurine
0.68;
0.47–0.98;
0.0395)
may
serve
as
exposures
for
ICH
SAH,
Additionally,
ascorbic
acid
3‐sulfate
significantly
decrease
risk
0.79;
0.66–0.94;
p
0.0065;
FDR
0.091).
Supplemental
analysis
suggested
‐formylanthranilic
hippurate.
There
are
significant
HS,
provides
further
rationale
prevention
monitoring
image
Язык: Английский
Immune control of brain physiology
Nature reviews. Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Key actors in neuropathophysiology: The role of γδ T cells
European Journal of Immunology,
Год журнала:
2024,
Номер
54(12)
Опубликована: Сен. 6, 2024
The
neuroimmune
axis
has
been
the
focus
of
many
studies,
with
special
emphasis
on
interactions
between
central
nervous
system
and
different
immune
cell
subsets.
T
cells
are
namely
recognized
to
play
a
critical
role
due
their
interaction
nerves,
by
secreting
cytokines
neurotrophins,
which
regulate
development,
function,
survival
neurons.
In
this
context,
γδ
particularly
relevant,
as
they
colonize
specific
tissues,
meninges,
have
wide
variety
complex
functions
that
balance
physiological
systems.
Notably,
not
only
key
components
for
maintaining
brain
homeostasis
but
also
responsible
triggering
or
preventing
inflammatory
responses
in
various
pathologies,
including
neurodegenerative
diseases
well
neuropsychiatric
developmental
disorders.
Here,
we
provide
an
overview
current
state
art
contribution
neuropathophysiology
delve
into
molecular
mechanisms
behind
it.
We
aim
shed
light
while
highlighting
upcoming
challenges
field
providing
new
clues
potential
therapeutic
strategies.
Язык: Английский