Oxytocin impairs wound-healing during social isolation but not social living

Psychoneuroendocrinology, Год журнала: 2025, Номер unknown, С. 107445 - 107445

Опубликована: Март 1, 2025

Язык: Английский

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Understanding autism: Causes, diagnosis, and advancing therapies

Brain Research Bulletin, Год журнала: 2025, Номер 227, С. 111411 - 111411

Опубликована: Май 29, 2025

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition marked by difficulties in social communication, languages, and repetitive behaviors. Its rising prevalence has made it critical global public health issue. ASD believed to arise from combination of genetic environmental influences. While some gene mutations associated with have been identified, most cases lack clear explanations. Evidence increasingly points early-life factors as key contributors ASD, including advanced parental age, maternal diabetes during pregnancy, infections, hormonal imbalances, certain medications, exposure air pollution. Currently, diagnosis relies on behavioral assessments, but the absence specific molecular biomarkers poses significant obstacles early detection targeted therapies. Encouragingly, research identified potential biomarkers, such neuroimaging classifiers, electroencephalography patterns, eye-tracking data, digital analytics, expression profiles, inflammatory chemokine markers, proteomic metabolomic gut microbiota characteristics. Potential therapeutical strategies under investigation include therapies, non-invasive brain stimulation, antioxidants, oxytocin, AVPR1a antagonists, PPAR agonists, mTOR inhibitors. This review explores across five areas: epidemiological trends, mechanisms, their roles, diagnostic therapeutic approaches.

Язык: Английский

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Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases

Neuroscience Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Язык: Английский

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