Food Bioscience, Год журнала: 2024, Номер 63, С. 105676 - 105676
Опубликована: Дек. 11, 2024
Язык: Английский
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Июль 15, 2024
The gut microbial ecosystem communicates bidirectionally with the brain in what is known as gut-microbiome-brain axis. Bidirectional signaling occurs through several pathways including via vagus nerve, circulation of metabolites, and immune activation. Alterations microbiota are implicated Alzheimer's disease (AD), a progressive neurodegenerative disease. Perturbations communities may affect within axis altered production metabolites ɣ-aminobutyric acid (GABA), primary inhibitory mammalian neurotransmitter. GABA has been shown to act on integrity modulation mucins tight junction proteins be involved nerve signal inhibition. GABAergic pathway dysregulated AD, responsive interventions. Gut recent interest neurological disorders, AD. Bacteroides Lactic Acid Bacteria (LAB), Lactobacillus, predominant producers GABA. This review highlights how temporal alterations associated AD pathway, intestinal barrier integrity, AD-associated inflammation.
Язык: Английский
Процитировано
17
Brain Behavior and Immunity, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
9
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Ноя. 8, 2024
The human gastrointestinal tract is colonized by a complex microbial ecosystem, the gut microbiota, which pivotal in maintaining host health and mediating resistance to diseases. This review delineates colonization (CR), critical defensive mechanism employed microbiota safeguard against pathogenic bacterial invasions, notably
Язык: Английский
Процитировано
4
Journal of Affective Disorders, Год журнала: 2025, Номер 374, С. 150 - 159
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 20, 2025
Salmonella is one of the most common foodborne pathogens, which can cause severe enteritis and intestinal microbiota imbalance. However, there are limited strategies currently available for preventing or treating Salmonella-induced colitis. Herein, we developed Cu/Mn-co-doped ZnO tandem nanozyme (ZnO-CM) with pH-responsive multienzyme-mimicking activities via doping engineering treatment Benefiting from co-doping Cu Mn, ZnO-CM nanospheres exhibit remarkable peroxidase-like activity in acidic condition superoxide dismutase- catalase-like neutral environment. Animal experiments show that efficiently inhibit bacterial growth, alleviate inflammation, restore barrier, resulting good antibacterial anti-inflammatory effects on Mechanistically, functions through inhibiting continuous accumulation ROS, increasing levels tight junction proteins occludin claudin-1, decreasing expression pro-inflammatory cytokines IL-1β IL-6 intestine. This work not only presents an effective paradigm colitis therapy, but also provides new sights into prevention other enteritis.
Язык: Английский
Процитировано
0
World Journal of Psychiatry, Год журнала: 2025, Номер 15(5)
Опубликована: Апрель 30, 2025
Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive, emotional, and behavioral impairments. The microbiota-gut-brain axis crucial in its pathophysiology, mediating communication between the gut brain through neural, immune, endocrine, metabolic pathways. Dysbiosis, or an imbalance microbiota, linked to neuroinflammation, systemic inflammation, neurotransmitter disruptions, all of which contribute symptoms schizophrenia. Gut microbiota-derived metabolites, such as short-chain fatty acids, influence function, including immune responses synthesis. These findings suggest that microbial imbalances exacerbate schizophrenia, providing novel perspective on disorder’s underlying mechanisms. Emerging microbiota-targeted therapies—such probiotics, prebiotics, dietary interventions, fecal microbiota transplantation—show promise adjunctive treatments, aiming restore balance improve clinical outcomes. While further research needed, targeting offers innovative approach schizophrenia management, with potential enhance patient outcomes quality life.
Язык: Английский
Процитировано
0
Neurochemistry International, Год журнала: 2024, Номер unknown, С. 105860 - 105860
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
Journal of Functional Foods, Год журнала: 2024, Номер 122, С. 106533 - 106533
Опубликована: Окт. 21, 2024
Язык: Английский
Процитировано
0
npj Biofilms and Microbiomes, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 19, 2024
The "gut-brain axis" is involved in many physiological processes. However, its role regulating mammary gland (MG) development remains unknown. In this study, we established the mice model of bilateral subdiaphragmatic vagotomy (Vago) to clarify effects on MG pubertal mice. results showed that Vago reduced ratio Lactobacillus and Bifidobacterium, neuronal excitability nucleus solitary tract (NTS), synthesis secretion BDNF, thereby slowing development. Transplanting gut microbiota recipient replicated these effects, transplanting Control did not alleviate effects. Galacto-Oligosaccharide (GOS), which up-regulates supplementation elevated NTS neuron excitability, development, but reversed benefits. conclusion, GOS enhances BDNF-mediated via axis".
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2024, Номер 63, С. 105676 - 105676
Опубликована: Дек. 11, 2024
Язык: Английский
Процитировано
0