The biological intersection between chemotherapy-related cognitive impairment and Alzheimer’s disease
American Journal Of Pathology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Alzheimer's
disease
(AD)
is
the
most
common
type
of
dementia
and
one
leading
causes
death
in
elderly
patients.
The
number
patients
with
AD
United
States
projected
to
double
by
2060.
Thus,
understanding
modifiable
risk
factors
for
an
urgent
public
health
priority.
In
parallel
patients,
cancer
survivors
estimated
increase
significantly,
up
80%
treated
chemotherapy
will
develop
cognitive
deficits,
termed
chemotherapy-related
impairment
(CRCI).
This
Review
discusses
biologically
plausible
pathways
underlying
both
disorders,
goal
why
a
proportion
may
be
at
higher
developing
AD.
Highlighted
are
E4
allele
apolipoprotein
E
gene,
neuroinflammation,
oxidative
stress,
DNA
damage,
mitochondrial
dysfunction,
neuronal
synaptic
loss,
cellular
senescence,
brain-derived
neurotrophic
factor
signaling,
white
matter
blood-brain
barrier/vascular
tau
pathology,
transposable
element
reactivation.
Язык: Английский
The Role of the Microbiome in Cancer Therapies
Hematology/Oncology Clinics of North America,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Exploring the Impact of Chemotherapy on the Emergence of Antibiotic Resistance in the Gut Microbiota of Colorectal Cancer Patients
Antibiotics,
Год журнала:
2025,
Номер
14(3), С. 264 - 264
Опубликована: Март 5, 2025
With
nearly
half
of
colorectal
cancer
(CRC)
patients
diagnosed
at
advanced
stages
where
surgery
alone
is
insufficient,
chemotherapy
remains
a
cornerstone
for
this
treatment.
To
prevent
infections
and
improve
outcomes,
antibiotics
are
often
co-administered.
However,
chemotherapeutic
interactions
with
the
gut
microbiota
cause
significant
non-selective
toxicity,
affecting
not
only
tumor
normal
epithelial
cells
but
also
microbiota.
This
toxicity
triggers
bacterial
SOS
response
loss
microbial
diversity,
leading
to
mutations
dysbiosis.
Consequently,
pathogenic
overgrowth
systemic
increase,
necessitating
broad-spectrum
intervention.
review
underscores
how
prolonged
antibiotic
use
during
chemotherapy,
combined
chemotherapy-induced
mutations,
creates
selective
pressures
that
drive
de
novo
antimicrobial
resistance
(AMR),
allowing
resistant
bacteria
dominate
gut.
compromises
treatment
efficacy
elevates
mortality
risk.
Restoring
diversity
may
mitigate
therapeutic
emerging
strategies,
such
as
fecal
transplantation
(FMT),
probiotics,
prebiotics,
show
considerable
promise.
Given
global
threat
posed
by
treatment,
prioritizing
stewardship
essential
optimizing
preventing
in
CRC
undergoing
chemotherapy.
Future
research
should
aim
minimize
chemotherapy’s
impact
on
develop
targeted
interventions
restore
affected
Язык: Английский
The role of oxytocin in mediating the relationships between social factors and chemotherapy-associated cognitive decline in female patients with breast cancer
Melina Seng,
Seth Adarkwah Yiadom,
Lauren Otto
и другие.
Psychoneuroendocrinology,
Год журнала:
2025,
Номер
176, С. 107428 - 107428
Опубликована: Март 15, 2025
Язык: Английский
Baseline gut microbiome alpha diversity predicts chemotherapy-induced gastrointestinal symptoms in patients with breast cancer
npj Breast Cancer,
Год журнала:
2024,
Номер
10(1)
Опубликована: Ноя. 15, 2024
Chemotherapy
frequently
causes
debilitating
gastrointestinal
symptoms,
which
are
inadequately
managed
by
current
treatments.
Recent
research
indicates
the
gut
microbiome
plays
a
role
in
pathogenesis
of
these
symptoms.
The
study
aimed
to
identify
pre-chemotherapy
markers
that
predict
symptom
severity
after
breast
cancer
chemotherapy.
Fecal
samples,
blood,
and
scores
were
collected
from
59
patients
before,
during,
Lower
alpha
diversity
abundance
specific
microbes
(e.g.,
Faecalibacterium)
predicted
greater
chemotherapy-induced
Notably,
tumor
diet
characteristics
associated
with
lower
diversity.
baseline
also
higher
disruption,
was
positively
diarrhea
results
indicate
certain
have
before
chemotherapy,
is
predictive
symptoms
less
resilient
microbiome.
These
may
be
strong
candidates
for
microbiome-directed
preventative
interventions
change).
Язык: Английский
Development and validation of a risk prediction model for cognitive impairment in breast cancer patients
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 15, 2024
Breast
cancer
patients
often
experience
cognitive
impairment
as
a
complication
during
treatment,
which
seriously
affects
their
quality
of
life.
This
study
aimed
to
assess
the
risk
factors
associated
with
in
breast
and
construct
validate
nomogram
model
predict
this
population.
In
study,
we
used
convenience
sampling
method
select
423
who
attended
Department
Surgery
at
First
Hospital
Jinzhou
Medical
University
from
September
2023
March
2024.
We
analyzed
these
patients'
through
LASSO
regression
logistic
analysis
develop
predictive
model.
The
was
evaluated
using
area
under
curve
(AUC)
receiver
operating
characteristic
(ROC)
calibration
decision
analysis.
found
prevalence
19.62%
among
patients.
A
developed
based
on
six
influencing
factors:
age,
educational
level,
pathological
type,
treatment
program,
emotional
state,
fatigue.
for
model's
training
validation
groups
0.944
0.931,
respectively.
curves
showed
high
degree
consistency,
(DCA)
indicated
good
clinical
applicability
demonstrates
discrimination,
calibration,
applicability,
making
it
more
intuitive
predictor
Язык: Английский