eLife, Год журнала: 2024, Номер 13
Опубликована: Ноя. 20, 2024
Gamma oscillations in brain activity (30–150 Hz) have been studied for over 80 years. Although the past three decades significant progress has made to try understand their functional role, a definitive answer regarding causal implication perception, cognition, and behavior still lies ahead of us. Here, we first review basic neural mechanisms that give rise gamma then focus on two main pillars exploration. The pillar examines major theories role information processing brain, also highlighting critical viewpoints. second reviews novel research direction proposes therapeutic oscillations, namely entrainment using sensory stimulation (GENUS). We extensively discuss both positive findings issues reproducibility GENUS. Going beyond gamma, propose third exploration, where generated endogenously by cortical circuits, is essential maintenance healthy circuit function. four classes interneurons, those expressing parvalbumin (PV), vasointestinal peptide (VIP), somatostatin (SST), nitric oxide synthase (NOS) take advantage endogenous perform active vasomotor control maintains homeostasis neuronal tissue. According this hypothesis, which call GAMER (GAmma MEdiated ciRcuit maintenance), act as ‘servicing’ rhythm enables efficient translation into vascular responses are optimal neurometabolic processes. an extension GENUS, rather than entrained plays fundamental role. Finally, several experiments test hypothesis.
Язык: Английский