Crossroads of Neurology and Virology: The Neurological Manifestations of COVID-19 DOI Creative Commons
Kirolos Eskandar

Ukrainian Neurosurgical Journal, Год журнала: 2024, Номер 30(4), С. 3 - 10

Опубликована: Дек. 30, 2024

Introduction: The COVID-19 pandemic, caused by SARS-CoV-2, has led to an unprecedented global health crisis. While primarily recognized for its respiratory implications, the virus shown a significant affinity nervous system, resulting in wide spectrum of neurological manifestations. This literature review explores intersection neurology and virology, focusing on acute long-term effects COVID-19. Methods: A comprehensive current was conducted using databases such as PubMed, Scopus, Web Science. Relevant studies were selected based their focus pathophysiology, clinical presentations, outcomes Special attention given peer-reviewed articles, meta-analyses, case reports published between 2019 2024. Results: identifies multiple mechanisms which SARS-CoV-2 invades including direct viral entry systemic inflammation. Acute manifestations include encephalitis, stroke, Guillain-Barré syndrome, while sequelae encompass cognitive impairment, neurodegeneration, psychiatric disorders. findings underscore complexity COVID-19’s impact with both immediate enduring effects. Conclusion: Neuro-COVID represents evolving challenge context pandemic. Understanding implications is crucial improving patient guiding future research. underscores need heightened awareness multidisciplinary approach effectively address complex neuro-COVID spectrum.

Язык: Английский

Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids DOI Creative Commons
Doris Loh, Russel J. Reíter

Exploration of neuroscience, Год журнала: 2025, Номер 4

Опубликована: Март 24, 2025

The SAR-CoV-2 virus has evolved to co-exist with human hosts, albeit at a substantial energetic cost resulting in post-infection neurological manifestations [Neuro-post-acute sequelae of SARS-CoV-2 infection (PASC)] that significantly impact public health and economic productivity on global scale. One the main molecular mechanisms responsible for development Neuro-PASC, individuals all ages, is formation inadequate proteolysis/clearance phase-separated amyloid crystalline aggregates—a hallmark feature aging-related neurodegenerative disorders. Amyloidogenesis during viral persistence natural, inevitable, protective defense response exacerbated by SARS-CoV-2. Acting as chemical catalyst, accelerates hydrophobic collapse heterogeneous nucleation amorphous amyloids into stable β-sheet aggregates. clearance aggregates most effective slow wave sleep, when high levels adenosine triphosphate (ATP)—a biphasic modulator biomolecular condensates—and melatonin are available solubilize removal. dysregulation mitochondrial dynamics SARS-CoV-2, particular fusion fission homeostasis, impairs proper distinct subpopulations can remedy challenges created diversion substrates away from oxidative phosphorylation towards glycolysis support replication maintenance. subsequent reduction ATP inhibition synthesis sleep results incomplete brain aggregates, leading commonly associated age-related Exogenous not only prevents dysfunction but also elevates production, effectively augmenting solubilizing effect moiety ensure timely, optimal disaggregation pathogenic prevention attenuation Neuro-PASC.

Язык: Английский

Процитировано

0
Acute and long-term neurological manifestations of Covid-19: insights from virology and neurology DOI Creative Commons
Kirolos Eskandar

Deleted Journal, Год журнала: 2025, Номер 16(1), С. 3 - 13

Опубликована: Март 30, 2025

Introduction This literature review examines the profound impact of Covid-19, caused by SARS-CoV-2, on nervous system. While virus is predominantly associated with respiratory complications, emerging evidence highlights its strong neurotropic potential, leading to a broad spectrum neurological disorders. explores convergence virology and neurology, emphasizing both acute long-term consequences disease. Methods A systematic following PRISMA guidelines was conducted using databases such as PubMed, Scopus, Web Science. Studies were selected based their relevance pathophysiology, clinical presentations, prolonged effects Covid-19. Preference given peer-reviewed research, including meta-analyses case reports published between 2020 2024. Results The identifies various pathways through which SARS-CoV-2 affects system, direct neuroinvasion systemic inflammatory responses. Acute conditions encephalitis, stroke, Guillain-Barré syndrome have been frequently reported, while chronic complications include cognitive dysfunction, neurodegenerative disorders, psychiatric disturbances. These findings highlight intricate enduring burden Conclusion Neuro-Covid presents an ongoing challenge in post-pandemic landscape. deeper understanding implications essential for enhancing patient management shaping future research directions. importance increased vigilance multidisciplinary strategy effectively address complex evolving Covid-19-related

Язык: Английский

Процитировано

0
Mitigating fatigue in long COVID patients with MYPplus: a clinical observation DOI Creative Commons
Yujin Choi, Jinseok Lee,

Jin‐Yong Joung

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 26, 2025

The COVID-19 pandemic has led to the emergence of a secondary public health crisis known as Long COVID. It is estimated that approximately 10% individuals who contact develop COVID, with fatigue and brain fog being among most commonly reported debilitating symptoms. However, no standardized or effective treatments are currently available. This observational study aimed evaluate efficacy MYPplus, an herbal formulation composed Astragali Radix, Salviae Aquilariae Lignum, in alleviating patients Subjects score 60 higher on Modified Korean version Chalder Fatigue scale (mKCFQ11) rating 5 visual analogue (VAS) took two capsules MYPplus (500 mg per capsule) twice daily for 4 weeks. Changes symptoms were assessed using mKCFQ11, Multidimensional Inventory (MFI-20), VAS, Brain overall quality life Short-Form Health Survey (SF-12). Additionally, levels three cytokines (TNF-α, TGF-β, IFN- γ) cortisol measured. Fifty participants successfully completed 4-week administration MYPplus. At baseline, severity was 75.3 ± 10.9 70.9 11.2 MFI-20, 7.5 1.2 8.4 1.1 45.3 17.8 SF-12. All parameters significantly improved (p < 0.01), decrease 46% 26% 49% 52% increase 59% SF-12, respectively. Unlikely others, plasma level TGF-β showed declining pattern after (from 765.0 1759.7 243.9 708.1 pg/mL, p = 0.07). No safety concerns observed. pilot suggests clinical potential managing focusing fatigue-related life. Further studies required confirm its large-scale randomized placebo-controlled trials future. been retrospectively registered identifier number KCT0008948 https://cris.nih.go.kr , 27/10/23.

Язык: Английский

Процитировано

0
More than “Brain Fog”: Cognitive Dysfunction and the Role of Occupational Therapy in Long COVID DOI

Helen Skiffington,

Ciara Breen

Cardiopulmonary Physical Therapy Journal, Год журнала: 2024, Номер 36(1), С. 39 - 49

Опубликована: Дек. 30, 2024

Long COVID is a disabling condition which affects occupational performance and quality of life. It interferes with activities daily living, work, many meaningful life roles. Cognitive dysfunction frequently reported symptom, yet it commonly overlooked. important that cognitive activity considered when working people long COVID, particularly identifying triggers post exertional symptom exacerbation. There are potential mechanisms could be driving in including neuroinflammation, viral persistence, vascular damage, orthostatic intolerance. to consider these help guide intervention. The purpose this clinical perspective highlight the debilitating impact those share key role therapists area. may missed on standardized assessments as they not sensitive enough due episodic nature symptoms. Occupational can play area experts assessing providing safe assessment rehabilitation.

Язык: Английский

Процитировано

2
Effects of SARS-CoV-2 Spike S1 Subunit on the Interplay Between Hepatitis B and Hepatocellular Carcinoma Related Molecular Processes in Human Liver DOI Creative Commons
Giovanni Colonna

Livers, Год журнала: 2024, Номер 5(1), С. 1 - 1

Опубликована: Дек. 31, 2024

Background: This study addresses a particular aspect of the biological behavior Spike subunit S1 SARS-CoV-2. Researchers observed acting freely in human organism during and after COVID-19 vaccination. One its properties is that it interacts one-to-one with proteins. 12 specific proteins liver. Methods: We used these as seeds to extract their functional relationships from proteome through enrichment. The interactome representing set metabolic activities which they are involved shows several molecular processes (KEGG), including some linked HBV (hepatitis B) HCC (hepatocellular carcinoma) many genes/proteins involved. Reports show that, COVID patients, reactivated or progressed cancer. Results: analyzed approaches understand whether two pathologies have independent progressions common progression. All our efforts consistently showed involving both significantly present all we used, making difficult any useful information about fate. Through BioGRID, extracted experimental data vivo but derived model cell systems. lack patient STRING results prevents diagnosis prediction real disease progression; therefore, can consider them “aseptic” data. Conclusion: tells us genes HVB-related pathways potential activate processes. gold standard. It comparison similar interactions found individual phenotypes phenotype favors hinders also suggests how use features. These sets constitute “toolkit”. In fact, if compare patient, will provide on level phenotypic state driving disease. composition an entire group broader more detailed than single marker. Therefore, protein compositions serve reference system doctors cases for personalized medicine diagnoses.

Язык: Английский

Процитировано

0
Crossroads of Neurology and Virology: The Neurological Manifestations of COVID-19 DOI Creative Commons
Kirolos Eskandar

Ukrainian Neurosurgical Journal, Год журнала: 2024, Номер 30(4), С. 3 - 10

Опубликована: Дек. 30, 2024

Introduction: The COVID-19 pandemic, caused by SARS-CoV-2, has led to an unprecedented global health crisis. While primarily recognized for its respiratory implications, the virus shown a significant affinity nervous system, resulting in wide spectrum of neurological manifestations. This literature review explores intersection neurology and virology, focusing on acute long-term effects COVID-19. Methods: A comprehensive current was conducted using databases such as PubMed, Scopus, Web Science. Relevant studies were selected based their focus pathophysiology, clinical presentations, outcomes Special attention given peer-reviewed articles, meta-analyses, case reports published between 2019 2024. Results: identifies multiple mechanisms which SARS-CoV-2 invades including direct viral entry systemic inflammation. Acute manifestations include encephalitis, stroke, Guillain-Barré syndrome, while sequelae encompass cognitive impairment, neurodegeneration, psychiatric disorders. findings underscore complexity COVID-19’s impact with both immediate enduring effects. Conclusion: Neuro-COVID represents evolving challenge context pandemic. Understanding implications is crucial improving patient guiding future research. underscores need heightened awareness multidisciplinary approach effectively address complex neuro-COVID spectrum.

Язык: Английский

Процитировано

0