Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis

Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)

Опубликована: Фев. 21, 2025

Abstract Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows immune cells to infiltrate central nervous system (CNS), worsening neuroinflammation and progression. We examine recent findings on interactions between CNS-resident microglia, forming self-perpetuating inflammatory cycle leading neuronal dysfunction. Moreover, this emphasizes developments dysregulation factors from both periphery CNS, their impact With ongoing development new therapeutic strategies, underscores importance modulating CNS therapy.

Язык: Английский

Approaches for studying neuroimmune interactions in Alzheimer’s disease

Trends in Immunology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский