Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies DOI Creative Commons
Cole Maguire,

Kristina Kashyap,

Elizabeth Matilda Oliveira Williams

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Abstract Background Long COVID (LC) is a novel condition that characterized by persistent symptoms last from months to years following SARS-CoV-2 infection. While LC vary widely, neuropathy one of the most prevalent and drastically affects patients’ quality life. However, underlying pathophysiology remains poorly understood. Here, we investigated prevalence potential mechanisms in largest cohort date. Methods We conducted an observational study 977 adults with at Dell Medical School. Participants underwent clinical assessments, skin punch biopsy, comprehensive metabolic, endocrine immunological profiling. A subset patients received treatment intravenous immunoglobulin (IVIG). Findings Neuropathic were reported 55% (534/977) participants, biopsy confirming small fiber 56.5% (48/85) cases, affecting both epidermal autonomic nerve fibers. Common risk factors for neuropathy, including metabolic disorders, did not fully explain neuropathic symptoms. general markers (lymphocyte, T cell, B cell count C reactive protein unremarkable, unexpectedly, detected anti-ganglioside antibodies (AGAs) 25% comparable rate other AGA-associated neuropathies. Longitudinal testing revealed AGA positivity, multiple elevated AGAs patients. In pilot eight patients, IVIG resulted improvement patient Interpretation Our findings reveal high LC, evidence suggesting autoimmune mechanism involving four The therapeutic response further supports pathophysiology, benefits immunomodulation

Язык: Английский

Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies DOI Creative Commons
Cole Maguire,

Kristina Kashyap,

Elizabeth Matilda Oliveira Williams

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Abstract Background Long COVID (LC) is a novel condition that characterized by persistent symptoms last from months to years following SARS-CoV-2 infection. While LC vary widely, neuropathy one of the most prevalent and drastically affects patients’ quality life. However, underlying pathophysiology remains poorly understood. Here, we investigated prevalence potential mechanisms in largest cohort date. Methods We conducted an observational study 977 adults with at Dell Medical School. Participants underwent clinical assessments, skin punch biopsy, comprehensive metabolic, endocrine immunological profiling. A subset patients received treatment intravenous immunoglobulin (IVIG). Findings Neuropathic were reported 55% (534/977) participants, biopsy confirming small fiber 56.5% (48/85) cases, affecting both epidermal autonomic nerve fibers. Common risk factors for neuropathy, including metabolic disorders, did not fully explain neuropathic symptoms. general markers (lymphocyte, T cell, B cell count C reactive protein unremarkable, unexpectedly, detected anti-ganglioside antibodies (AGAs) 25% comparable rate other AGA-associated neuropathies. Longitudinal testing revealed AGA positivity, multiple elevated AGAs patients. In pilot eight patients, IVIG resulted improvement patient Interpretation Our findings reveal high LC, evidence suggesting autoimmune mechanism involving four The therapeutic response further supports pathophysiology, benefits immunomodulation

Язык: Английский

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