Postpartum Maternal Stress is Unrelated to the Infant Fecal Microbiome, but is Associated With the Human Milk Microbiome in Exclusively Breastfeeding Mother‐Infant Dyads: The Mother‐Infant Microbiomes, Behavior, and Ecology Study (MIMBES) DOI Creative Commons
Elizabeth A. Holdsworth, Janet E. Williams, Ryan M. Pace

и другие.

American Journal of Human Biology, Год журнала: 2025, Номер 37(5)

Опубликована: Май 1, 2025

ABSTRACT Objectives This study aimed to evaluate whether postpartum maternal stress is associated with infant gastrointestinal microbiome composition and diversity, this relationship may be mediated by caregiving breastfeeding behaviors human milk (HMM) composition. Methods Infant fecal samples were collected from 51 exclusively mother‐infant dyads in the Pacific Northwest between 1 6 months postpartum. sequencing read counts > 773 ( n = 48) 200 46) analyzed for bacterial alpha diversity (richness, Shannon diversity), beta (Bray–Curtis dissimilarity), genera differential abundances. (IFM) measures tested associations mothers' self‐reported Parenting Stress Index total subscale scores regression envfit (beta MaAsLin2 (genera abundance) models. Potential mediators of IFM explored (observed time breastfeeding; maternal–infant physical contact frequency; HMM abundance). Results Maternal was not or diversities. Two subscales abundances Erysipelotrichaceae UCG‐003 (positively) Eggerthella (negatively) feces. two (Role Restriction, Attachment) positively (q attachment 0.07) negatively richness 0.08, q role 0.03). Conclusions Postpartum consistently during exclusive breastfeeding. However, suggesting that might influence other developmental pathways infant.

Язык: Английский

Supervised Modelling of Longitudinal Human Milk and Infant Gut Microbiome Reveal Maternal Pre-Pregnancy BMI and Early Life Growth Interactions DOI Creative Commons
Rasmus Riemer Jakobsen, Geert Roelof van der Ploeg, Ulrik Kræmer Sundekilde

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract Maternal obesity is a key risk factor for excessive foetal growth and childhood obesity, yet its influence on human milk (HM) composition the infant gut microbiome development remains unclear. This study examined 169 mother-infant dyads analyzing 570 HM metabolome, 495 microbiome, 348 faecal samples over three months of exclusive breastfeeding, alongside anthropometric data through years postpartum. While BMI was not directly correlated with (weight-for-length/height z-score), N-way Partial Least Squares modelling revealed microbial metabolite signatures linked to maternal ppBMI growth. High were associated altered oligosaccharides enrichment Bifidobacterium spp. in gut. In contrast, elevated simple sugars, amino acid derivatives, Klebsiella Escherichia relative abundance slower These findings highlight maternal-infant nutritional dynamics, informing targeted strategies support

Язык: Английский

Процитировано

0
Postpartum Maternal Stress is Unrelated to the Infant Fecal Microbiome, but is Associated With the Human Milk Microbiome in Exclusively Breastfeeding Mother‐Infant Dyads: The Mother‐Infant Microbiomes, Behavior, and Ecology Study (MIMBES) DOI Creative Commons
Elizabeth A. Holdsworth, Janet E. Williams, Ryan M. Pace

и другие.

American Journal of Human Biology, Год журнала: 2025, Номер 37(5)

Опубликована: Май 1, 2025

ABSTRACT Objectives This study aimed to evaluate whether postpartum maternal stress is associated with infant gastrointestinal microbiome composition and diversity, this relationship may be mediated by caregiving breastfeeding behaviors human milk (HMM) composition. Methods Infant fecal samples were collected from 51 exclusively mother‐infant dyads in the Pacific Northwest between 1 6 months postpartum. sequencing read counts > 773 ( n = 48) 200 46) analyzed for bacterial alpha diversity (richness, Shannon diversity), beta (Bray–Curtis dissimilarity), genera differential abundances. (IFM) measures tested associations mothers' self‐reported Parenting Stress Index total subscale scores regression envfit (beta MaAsLin2 (genera abundance) models. Potential mediators of IFM explored (observed time breastfeeding; maternal–infant physical contact frequency; HMM abundance). Results Maternal was not or diversities. Two subscales abundances Erysipelotrichaceae UCG‐003 (positively) Eggerthella (negatively) feces. two (Role Restriction, Attachment) positively (q attachment 0.07) negatively richness 0.08, q role 0.03). Conclusions Postpartum consistently during exclusive breastfeeding. However, suggesting that might influence other developmental pathways infant.

Язык: Английский

Процитировано

0