Microbiome, Год журнала: 2024, Номер 12(1)
Опубликована: Ноя. 1, 2024
Depression and anxiety significantly impact the quality of life in individuals with Cushing's disease (CD), which originates from pituitary neuroendocrine tumors (PitNETs), yet our understanding underlying mechanisms is limited. There substantial evidence linking gut microbes to depression, anxiety, endocrinology.
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(7), С. 1054 - 1054
Опубликована: Апрель 4, 2024
The microbiota-gut-brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health disease. Dysbiosis, disturbance in gut microbiome equilibrium, can significantly impact MGB axis, leading to alterations microbial composition function. Emerging evidence highlights connection between microbiota neurological psychiatric disorders, including depression. This review explores potential psychobiotics managing depressive emphasizing their role restoring balance axis. Psychobiotics exhibit positive effects on intestinal barrier, immune response, cortisol levels, hypothalamic-pituitary-adrenal (HPA) Studies suggest that probiotics may serve as an adjunct therapy for depression, especially treatment-resistant cases. discusses key findings from studies interventions, gut-brain mental health. increasing acceptance expanded concept underscores importance microorganisms well-being. As our understanding microbiome's disease grows, emerge promising agents addressing issues, providing new avenues therapeutic interventions disorders.
Язык: Английский
Процитировано
13
Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17
Опубликована: Июль 18, 2024
The gut-brain axis (GBA) plays a dominant role in maintaining homeostasis as well contributes to mental health maintenance. pathways that underpin the expand from macroscopic interactions with nervous system, molecular signals include microbial metabolites, tight junction protein expression, or cytokines released during inflammation. dysfunctional GBA has been repeatedly linked occurrence of anxiety- and depressive-like behaviors development. importance inflammatory aspects altered recently highlighted literature. Here we summarize current reports on signaling which involves immune response within intestinal blood-brain barrier (BBB). We also emphasize effect stress altering barriers' permeability, therapeutic potential microbiota restoration by probiotic administration transplantation, based latest animal studies. Most research performed various models showed an association between behaviors, dysbiosis gut microbiota, disruption permeability simultaneous changes BBB integrity. It could be postulated under conditions impaired communication across may therefore represent significant mechanism allowing affect brain functions.
Язык: Английский
Процитировано
10
Asian Journal of Psychiatry, Год журнала: 2025, Номер 105, С. 104411 - 104411
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Neuroscience Letters, Год журнала: 2025, Номер unknown, С. 138218 - 138218
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International review of neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Affective Disorders, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Neurobiology of Disease, Год журнала: 2024, Номер 199, С. 106598 - 106598
Опубликована: Июль 11, 2024
Myocardial infarction (MI) and depression are leading causes of mortality morbidity globally, these conditions increasing recognized as being fundamentally interconnected. The recently gut-heart-brain axis offers insights into following MI, but effective treatments for this comorbidity remain lacking. To address medical need, we employed an animal model MI to investigate the potential repurposing sotagliflozin (SOTA), approved sodium-glucose cotransporter 1 2 (SGLT1/2) inhibitor diabetes, managing identifying SOTA-associated microbial mechanisms. SOTA treatment improved cardiac dysfunction alleviated depression-like behaviors induced by accompanied alterations in gut microbiota composition, such changes Prevotellaceae NK3B31 group, Alloprevotella, UCG-001. Moreover, fecal transplantation (FMT) using samples from SOTA-treated mice demonstrated that contributed beneficial effects on mice. Intriguingly, FMT-based intervention concordance analysis before after FMT suggested UCG-001 were associated with SOTA. Furthermore, functional prediction correlation support significance dynamic communities. In conclusion, findings suggest could serve a drug ameliorate depressive symptoms patients via through axis.
Язык: Английский
Процитировано
2
Proceedings of Anticancer Research, Год журнала: 2024, Номер 8(3), С. 68 - 73
Опубликована: Июнь 19, 2024
This paper aims to review the association between gut microbiota and respiratory system diseases, explore their potential mechanisms clinical significance. Gut microbiota, as an important microbial ecosystem in human body, has profound effects on host health. Recent studies have shown that imbalance of is closely related occurrence development including asthma, chronic obstructive pulmonary disease (COPD), pneumonia. We comprehensively analyzed current research progress found may affect diseases through various pathways, immune regulation, inflammatory responses, airway mucus secretion. Additionally, environmental factors, lifestyle, dietary habits are also Understanding relationship not only helps reveal but provides a theoretical basis for new treatment strategies. Future should focus exploring types functions conducting trials based this, investigating modulation prevention providing directions personalized medicine.
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Июль 10, 2024
Abstract Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an number of surgical procedures being performed, prevention management perioperative have garnered attention. While factors such as age, lifestyle, genetics, education are known to influence development cognitive dysfunction, recent research has highlighted role gut microbiota in neurological health. An increased abundance pro-inflammatory can trigger worsen neuroinflammation, neuronal cell damage, impaired cellular autophagy. Moreover, inflammation-promoting disrupt immune function, impair neuroautophagy, affect production circulation extracellular vesicles neurotransmitters. These collectively play onset advancement impairment. This narrative review delves into molecular mechanisms through which their derivatives contribute impairment, focusing impact anesthesia surgery, changes microbial populations, impairment associations. The study suggests that alterations various bacterial species metabolites pre- post-surgery may be linked Furthermore, potential probiotics or prebiotics addressing discussed, offering promising avenue investigating treatment disorders.
Язык: Английский
Процитировано
0