Unbalance CD4+IL-10+ and more activated and exhausted CD8+ lymphocytes characterized patients with a Major Depressive Episode. DOI

Vera Tifner,

Federico M. Daray, Jhon Esteban López-Carvajal

и другие.

Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2025, Номер unknown, С. 103563 - 103563

Опубликована: Март 1, 2025

Depression is a highly prevalent psychiatric condition referred to as major depressive episode (MDE). The underlying causes and mechanisms of depression remain poorly elucidated and, in consequence, the efficacy current therapies. Inflammation has been proposed contribute pathophysiology MDE with altered innate adaptive immune responses. present work aimed shed light on effector CD4+ T helper (Th) cell subsets response activation exhaustion CD8+ lymphocytes peripheral blood patients MDE. Patients (n = 57) healthy controls (HCs) 34) were recruited. intracellular production interferon (IFN) γ (Th1), interleukin (IL)-17 (Th17), IL-10 (CD4+ IL-10+) exhausted status evaluated by flow cytometry. frequencies Th1 Th17 cells did not show statistical differences, but lower percentage CD4+IL-10+ (P < 0.05) CD4+IFNγ+IL-10+ .01) found compared HCs. reduction population negatively correlated number episodes .05 P duration illness .01). A higher proportion activated CD8+CD69+ .0001) potentially phenotype CD8+PD1+LAG3+ observed, which positively severity, episodes, Altogether, are characterized unbalanced Th1/Th17/CD4+IL-10+ increased cytotoxic cells. Therapeutic strategies restoring this balance effective control inflammatory responses may be beneficial SIGNIFICANCE STATEMENT: (MDE) remains defined, hampering development more tailored therapeutic interventions. initiate or maintain This study demonstrates that MDE, showing cells; meanwhile, an phenotype. provides valuable insights into lymphocyte response, should lead advances therapeutics mood disorders.

Язык: Английский

Unbalance CD4+IL-10+ and more activated and exhausted CD8+ lymphocytes characterized patients with a Major Depressive Episode. DOI

Vera Tifner,

Federico M. Daray, Jhon Esteban López-Carvajal

и другие.

Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2025, Номер unknown, С. 103563 - 103563

Опубликована: Март 1, 2025

Depression is a highly prevalent psychiatric condition referred to as major depressive episode (MDE). The underlying causes and mechanisms of depression remain poorly elucidated and, in consequence, the efficacy current therapies. Inflammation has been proposed contribute pathophysiology MDE with altered innate adaptive immune responses. present work aimed shed light on effector CD4+ T helper (Th) cell subsets response activation exhaustion CD8+ lymphocytes peripheral blood patients MDE. Patients (n = 57) healthy controls (HCs) 34) were recruited. intracellular production interferon (IFN) γ (Th1), interleukin (IL)-17 (Th17), IL-10 (CD4+ IL-10+) exhausted status evaluated by flow cytometry. frequencies Th1 Th17 cells did not show statistical differences, but lower percentage CD4+IL-10+ (P < 0.05) CD4+IFNγ+IL-10+ .01) found compared HCs. reduction population negatively correlated number episodes .05 P duration illness .01). A higher proportion activated CD8+CD69+ .0001) potentially phenotype CD8+PD1+LAG3+ observed, which positively severity, episodes, Altogether, are characterized unbalanced Th1/Th17/CD4+IL-10+ increased cytotoxic cells. Therapeutic strategies restoring this balance effective control inflammatory responses may be beneficial SIGNIFICANCE STATEMENT: (MDE) remains defined, hampering development more tailored therapeutic interventions. initiate or maintain This study demonstrates that MDE, showing cells; meanwhile, an phenotype. provides valuable insights into lymphocyte response, should lead advances therapeutics mood disorders.

Язык: Английский

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