PubMed, Год журнала: 2024, Номер 44(2), С. 270 - 279
Опубликована: Фев. 20, 2024
To investigate the protective effect of resveratrol on intestinal barrier in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse models and its mechanism for regulating TLR4/MyD88/NF-κB signaling to protect dopaminergic neurons.
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(2), С. 308 - 308
Опубликована: Янв. 19, 2024
Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain-gut axis is an object that remains the target of modern research, it not without reason many enrich with diet in its name. Numerous connections mutual correlations have become basis for seeking answers questions pathology as well human physiology. Disorders this homeostasis dysbiosis itself accompany neurodegenerative diseases such Alzheimer's Parkinson's. Heavily dependent on external factors, modulation gut microbiome represents opportunity advance treatment Probiotic interventions, synbiotic or fecal transplantation can undoubtedly support biotherapeutic process. A special role played by diet, which provides metabolites directly affect body microbiota. holistic view organism therefore essential.
Язык: Английский
Процитировано
14
Nutrients, Год журнала: 2024, Номер 16(12), С. 1938 - 1938
Опубликована: Июнь 19, 2024
Type 2 diabetes is a disease with significant health consequences for the individual. Currently, new mechanisms and therapeutic approaches that may affect this are being sought. One of them association type microbiota. Through enteric nervous system gut–microbiota axis, microbiota affects functioning body. It has been proven to have real impact on influencing glucose lipid metabolism insulin sensitivity. With dysbiosis, there increased bacterial translocation through disrupted intestinal barrier inflammation in In diabetes, microbiota’s composition altered with, example, more abundant class Betaproteobacteria. The these disorders linked involving short-chain fatty acids, branched-chain amino lipopolysaccharide, among others. Interventions focusing gut gaining traction as promising approach management. Studies currently conducted effects supply probiotics prebiotics, well fecal transplantation, course diabetes. Further research will allow us fully develop our knowledge subject possibly best treat prevent
Язык: Английский
Процитировано
6
Nutrients, Год журнала: 2024, Номер 16(16), С. 2646 - 2646
Опубликована: Авг. 10, 2024
This narrative review synthesizes current evidence regarding anti-inflammatory dietary patterns and their potential benefits for individuals with mental disorders neurodegenerative diseases. Chronic low-grade inflammation is increasingly recognized as a key factor in the etiology progression of these conditions. The examines neuroprotective properties components food groups, focusing on whole foods rather than specific nutrients or supplements. Key showing include fruits vegetables (especially berries leafy greens), grains, legumes, fatty fish rich omega-3, nuts (particularly walnuts), olive oil, fermented foods. These are generally antioxidants, fiber, bioactive compounds that may help modulate inflammation, support gut health, promote neuroprotection. Conversely, ultra-processed foods, red meat, sugary beverages be harmful. Based this evidence, we designed Brain Anti-Inflammatory Nutrition (BrAIN) diet. mechanisms diet modulation microbiota gut-brain axis, regulation inflammatory pathways, reduction oxidative stress, promotion neuroplasticity. BrAIN shows promise an aid to manage disorders.
Язык: Английский
Процитировано
6
Laws, Год журнала: 2024, Номер 13(4), С. 46 - 46
Опубликована: Июль 11, 2024
International studies have linked the consumption of ultra-processed foods with a variety non-communicable diseases. Included in this growing body research is evidence linking to mental disorders, aggression, and antisocial behavior. Although idea that dietary patterns various nutrients or additives can influence brain behavior has long history criminology, absence plausible mechanisms convincing intervention trials, topic was mostly excluded from mainstream discourse. The emergence across nutritional neuroscience psychology/psychiatry, combined mechanistic bench science, human provided support epidemiological findings, legitimacy concept criminology. Among emergent research, microbiome sciences illuminated pathways socioeconomic environmental factors, including foods, aggression Here review, we examine burgeoning related food addiction, explore its relevance criminal justice spectrum—from prevention intervention—and courtroom considerations diminished capacity. We use auto-brewery syndrome as an example intersecting diet gut science been used refute mens rea charges. legalome—microbiome omics applied forensic legal psychology—appears set emerge important consideration matters law, justice.
Язык: Английский
Процитировано
5
Nutrients, Год журнала: 2024, Номер 16(20), С. 3570 - 3570
Опубликована: Окт. 21, 2024
Recent research highlights the growing interest in impact of nutrition on cognitive health and function disease, as dietary habits are increasingly recognized crucial factors relation to brain function. This focus is especially important given rising prevalence neurodegenerative diseases decline associated with poor choices. Links now being sought between microbiota gut-brain axis. Mechanisms proposed that include low-grade chronic neuroinflammation, influence short-chain fatty acids, or disruption glial cells transmitters brain.
Язык: Английский
Процитировано
4
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(1), С. 265 - 265
Опубликована: Янв. 5, 2025
Background: Depression often coexists with anemia, potentially sharing common pathways, highlighting the need for treatments addressing both conditions simultaneously. This study evaluated effect of probiotics on red blood cell (RBC) parameters in adults depressive disorder. We hypothesized that would positively influence RBC parameters, modulated by baseline inflammation or dietary intake, improved function correlating better antidepressant outcomes. Methods: secondary analysis a two-arm, randomized, double-blind, controlled trial involved 116 Participants received probiotic formulation containing Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 placebo 60 days. Data from 97 subjects were analyzed including hemoglobin (HGB), count, hematocrit (HCT), mean corpuscular volume (MCV), concentration (MCH), (MCHC), distribution width (RDW). Results: Probiotic supplementation did not result significant changes compared to placebo. However, may help stabilize HGB, HCT, MCH, MCHC levels, preventing fluctuations observed group. Conclusions: While showed potential benefits symptoms, observed. Larger studies are needed clarify mechanisms clinical implications.
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(3), С. 552 - 552
Опубликована: Янв. 31, 2025
Background/Objectives: Irritable Bowel Syndrome (IBS) is a disorder of the gut-brain axis for which gastroenterologist most often consulted. Gastrointestinal symptoms and decreased quality life lead to considerable burden disease. The exact causes IBS are not well understood, no standard therapy has been established. primary outcome study focused on improvements assessed through validated questionnaire IBS-Severity Scoring System (IBS-SSS). Similarly, secondary outcomes geared towards improvement (IBS-Quality Life (IBS-QoL) Quality Index (GIQLI)) specific (bloating, abdominal distension, feeling heaviness, pain, flatulence), were self-administered questionnaires. Intestinal habits (consistency frequency depositions) subject stratification into diarrhoea (IBS-D), constipation (IBS-C), mixed type (IBS-M), as treatment tolerability also evaluated. Methods: A randomised, placebo-controlled, double-blind, clinical trial was conducted 156 enrolled patients (79 female 77 male), aged 18–70 years, randomised (1:1 allocation ratio) receive either two capsules per day food supplement (containing 480 mg complex tannin extracts) or placebo 56 days. Linear random intercept models (LMM) used analyse all experimental variables Results: Supplementation resulted in significant (p < 0.05) IBSS score, with respect group, changing condition going from mild (242.3 ± 89.8) moderate (148.1 60.6). indicators concerning life, intestinal 0.05). Furthermore, tannin-based showed ability modulate response different symptomatology such constipation, without side effects being reported. Conclusions: use based chestnut quebracho tannins presents great application potential management IBS-related disorders, peculiarity resolving opposite symptoms, indiscriminately.
Язык: Английский
Процитировано
0
Brain Research, Год журнала: 2025, Номер unknown, С. 149575 - 149575
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Gastrointestinal Disorders, Год журнала: 2025, Номер 7(2), С. 32 - 32
Опубликована: Апрель 29, 2025
Background: The relationship between gut microbiota and metabolic health has garnered significant attention in recent years. In this study, we aim to explore the intricate link outcomes, with a focus on lifestyle factors such as smoking, diet, living environment. Materials Methods: We investigated profiles of adult patients type 2 diabetes, all receiving metformin therapy, assess how impact health. Key parameters body composition indices were measured, alongside composition. Results: Our cohort included 30 patients, identified associations smoking adverse changes, well dietary patterns favoring plant-based foods correlating improved outcomes. Urban participants displayed distinct markers compared their rural counterparts, highlighting potential influence environmental factors. Conclusions: current data does not directly demonstrate causal usage specific changes These findings align existing literature while providing novel insights into population dynamics. Future research should longitudinal studies interventions targeting further unravel its therapeutic potential.
Язык: Английский
Процитировано
0
Schizophrenia Research, Год журнала: 2025, Номер 281, С. 30 - 44
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0