Prevalência do uso de antidepressivos em pacientes com deficiência de cobalamina: um estudo transversal
Brazilian Journal of Health Review,
Год журнала:
2025,
Номер
8(1), С. e76731 - e76731
Опубликована: Янв. 10, 2025
Depressão
representa
um
importante
problema
de
saúde,
pois
pode
trazer
incapacitação.
Sua
fisiopatologia
não
é
totalmente
esclarecida
e
seu
diagnóstico
feito
com
base
nos
sintomas
persistentes
por
mais
duas
semanas.
A
vitamina
B12
grupo
micronutrientes
chamados
cobalaminas
encontrada
exclusivamente
em
alimentos
origem
animal.
Tal
tem
papel
na
homeostase,
participando
desde
a
multiplicação
celular
(síntese
DNA)
processos
regulação
do
sistema
nervoso
central,
como
o
bom
funcionamento
dos
neurotransmissores
mielinização
neurônios.
deficiência
se
dá
principalmente
pela
má
absorção
entérica,
podendo
levar
quadros
anemia,
neuropatia,
fadiga
declínio
cognitivo.
associação
depressão
ainda
foi
estabelecida,
havendo
discordância
literatura.
Este
estudo
teve
intuito
comparar
diferentes
grupos
participantes
que
dosaram
relação
uso
antidepressivo,
visando
estabelecer
uma
possível
entre
presença
depressão.
Para
tanto,
foram
utilizados
dados
fornecidos
laboratório
análises
clínicas
situado
no
interior
estado
São
Paulo.
prevalência
aqueles
apresentaram
B12,
resultado
normal
ou
acima
valor
referência
parece
indicar
cobalamina
antidepressivos.
necessários,
portanto,
estudos
para
elucidar
esse
tema
obscuro.
Compound B vitamins mitigate post-traumatic stress disorder-like behaviors induced by single prolonged stress in rats by inhibiting hippocampal mitochondrial DNA methylation
Journal of Neurorestoratology,
Год журнала:
2025,
Номер
unknown, С. 100187 - 100187
Опубликована: Янв. 1, 2025
Язык: Английский
Associations between the intake of single and multiple dietary vitamins and depression risk among populations with chronic kidney disease
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 4, 2025
Background
The
effects
of
multivitamin
exposure
on
depression
among
patients
with
chronic
kidney
disease
(CKD)
have
not
been
thoroughly
explored.
This
study
aimed
to
explore
the
individual
vitamin
intakes
and
joint
effect
intake
multiple
vitamins
(including
A,
B
1
,
2
6
12
C,
D,
E,
K)
risk
in
participants
CKD.
Methods
A
total
3,123
CKD
(weighted
n
=
25,186,480)
from
National
Health
Nutrition
Examination
Survey
database
2007
2014
were
included.
Weighted
multivariate
logistic
regression
models
utilized
analyze
associations
dietary
risk.
Additionally,
Bayesian
kernel
machine
(BKMR)
weighted
quantile
sum
(WQS)
performed
evaluate
nine
Results
overall
prevalence
was
approximately
11.3%
participants.
In
fully
adjusted
model,
high
(OR:
0.54,
95%
CI:
0.40–0.74),
0.67,
0.48–0.95),
0.70,
0.49–0.99),
D
0.67.
0.48–0.94),
K
0.61,
0.44–0.85)
associated
a
reduced
likelihood
depression.
BKMR
WQS
showed
that
had
significant
negative
depression,
being
largest
contributor
two
models.
Lastly,
reflected
mixed
0.82,
0.69–0.99).
Conclusion
High
are
low
Furthermore,
co-exposure
is
crucial
factor
contributing
this
population.
Язык: Английский
Diet-Gut Microbiome Nexus: A New Paradigm in Food-Based Mental Disease Therapeutics
Food Reviews International,
Год журнала:
2025,
Номер
unknown, С. 1 - 27
Опубликована: Март 19, 2025
Язык: Английский
Homocysteine Induced N6-Methyldeoxyadenosine Modification Perturbation Elicits Mitochondria Dysfunction Contributes to the Impairment of Learning and Memory Ability Caused by Early Life Stress in Rats
Опубликована: Янв. 1, 2025
Язык: Английский
Evaluating the causal effects of circulating metabolic biomarkers on Alzheimer's disease
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2025,
Номер
138, С. 111309 - 111309
Опубликована: Март 2, 2025
Язык: Английский
Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitamin C status: A randomized, double-blind, placebo-controlled trial
Brain Behavior and Immunity,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
The
intricate
relationship
between
nutrition,
gut
microbiome,
and
mental
health
has
gained
increasing
attention.
We
aimed
to
determine
how
vitamin
C
supplementation
improves
vitality
through
the
microbiome
associated
neurological
immunological
changes.
used
16S
rRNA
sequencing
analyze
microbiota
profiles
of
participants
from
our
previous
trial,
in
which
healthy
young
adults
(20-39
years)
with
inadequate
serum
levels
(<50
μM)
received
500
mg
or
a
placebo
twice
daily
for
4
weeks
(vitamin
C,
n
=
21;
placebo,
19).
examined
whether
changes
correlated
previously
determined
indices,
including
Stroop
test
performance,
work
engagement,
brain-derived
neurotrophic
factor
(BDNF)
levels.
Serum
concentrations
microbial-derived
molecules,
cytokines,
neurotransmitters
were
analyzed
using
enzyme-linked
immunosorbent
assay,
electrochemiluminescence-based
immunoassay,
ultra-high-performance
liquid
chromatography-mass
spectrometry.
Monocyte
subpopulations
peripheral
blood
quantified
fluorescence-activated
cell
sorting
analysis.
Vitamin
increased
relative
abundance
Bacillaceae
Anaerotruncus,
while
decreasing
Desulfovibrio,
Desulfovibrio
reduction
correlating
performance.
Moreover,
showing
substantial
("responders")
demonstrated
greater
BDNF
increases
stronger
correlations
L-DOPA
engagement
scores
than
did
non-responders.
In
addition,
suppressed
inflammatory
responses
concurrent
lipopolysaccharide
levels,
responders
showed
decreases
IL-10
classical
monocyte
frequencies
conclusion,
modulates
composition,
particularly
by
reducing
abundance,
extent
improvements
decreased
inflammation.
This
study
provides
insights
into
as
critical
dietary
intervention,
it
may
modulate
its
influence
on
gut-brain-immune
axis.
Язык: Английский
The association of vitamin deficiency with depression risk in late-life depression: a review
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 15, 2025
Late-life
depression
(LLD),
a
growing
public
health
challenge
in
aging
societies,
profoundly
impacts
physical
and
mental
by
exacerbating
cognitive
decline,
functional
disability,
comorbid
chronic
diseases.
Emerging
research
highlights
vitamin
supplementation
as
promising
adjunctive
therapy
for
LLD,
targeting
its
multifactorial
pathogenesis
involving
mitochondrial
dysfunction,
neuroinflammation,
oxidative
stress.
Specific
vitamins,
including
B-complex
vitamins
(B1,
B6,
B9,
B12),
D,
antioxidants
(C,
E),
demonstrate
therapeutic
potential
through
mechanisms
ranging
from
neurotransmitter
regulation
to
function
enhancement.
For
instance,
D
modulates
serotonin
synthesis
calcium
signaling,
while
B
mitigate
homocysteine-mediated
neurotoxicity
support
energy
metabolism.
Antioxidants
counteract
neural
damage
linked
depressive
severity.
Clinical
studies
reveal
that
deficiency
(<20
ng/mL)
correlates
with
elevated
risk,
combined
B-vitamin
shows
symptom
alleviation
nutritionally
deficient
subgroups.
However,
evidence
remains
heterogeneous
due
variability
dosing
protocols,
bioavailability,
population-specific
factors
like
comorbidities.
Despite
evidence,
critical
gaps
persist
regarding
optimal
dosages,
bioavailability
variations,
long-term
outcomes
elderly
populations.
This
review
synthesizes
current
on
vitamin-mediated
cellular
pathways
LLD
management,
evaluates
clinical
efficacy
across
interventions,
proposes
personalized
nutritional
strategies
optimize
outcomes.
By
integrating
mechanistic
insights
data,
this
analysis
aims
guide
evidence-based
protocols
within
geriatric
care
frameworks.
Язык: Английский
Targeting Divergent Pathways in the Nutritional Management of Depression
Nutrients,
Год журнала:
2024,
Номер
16(16), С. 2806 - 2806
Опубликована: Авг. 22, 2024
The
nutritional
management
of
depression
has
long
been
discussed,
due
to
the
perceived
benefit
a
product
having
less
side
effects
than
pharmaceutical
agents.
Candidate
nutrients
for
managing
include
vitamin
D,
B
vitamins,
tryptophan,
branch
chain
amino
acids,
probiotics,
omega-3
fatty
folate/methylfolate
(also
known
as
B9),
and
s-adenosylmethionine.
This
paper
provides
narrative
review
three
which
have
significant
scientific
support
depression.
A
deficiency
in
each
nutrient
is
associated
with
depression,
interventional
studies
indicate
that
correction
may
provide
clinical
benefit.
We
present
epidemiological
evidence,
mechanistic
explanation
these
nutrients.
Finally,
relevant
guidelines
are
presented
their
conclusion
role
Язык: Английский
Potential Benefits of Specific Nutrients in the Management of Depression and Anxiety Disorders
Deleted Journal,
Год журнала:
2024,
Номер
3(1), С. 1 - 10
Опубликована: Дек. 26, 2024
Depression
and
anxiety
are
widespread
mental
disorders
globally,
imposing
significant
burdens
on
both
individual
societal
health.
With
the
continuous
advancement
of
research
in
field
health,
influence
nutrition
psychological
well-being
has
emerged
as
an
increasingly
important
area
study.
A
growing
body
evidence
suggests
that
specific
nutrients
may
play
a
crucial
role
prevention
treatment
depression
anxiety,
particularly
regulation
neurobiological
mechanisms.
Nutrients
such
omega-3
fatty
acids,
vitamin
D,
B
vitamins,
minerals,
antioxidants
have
been
shown
to
offer
potential
benefits
modulating
brain
function,
alleviating
inflammatory
responses,
enhancing
neurotransmission.
This
review
consolidates
recent
relationship
between
these
depression/anxiety,
exploring
possible
mechanisms
through
which
they
contribute
neural
health
improvement.
The
paper
also
outlines
future
directions
this
area.
By
providing
comprehensive
overview,
aims
new
insights
for
interventions
promote
clinical
application
nutritional
approaches
care.
Язык: Английский