A new method for identifying and evaluating depressive disorders in young people based on cognitive neurocomputing: an exploratory study
Frontiers in Computational Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 25, 2025
Depressive
disorders
are
one
of
the
most
common
mental
among
young
people.
However,
there
is
still
a
lack
objective
means
to
identify
and
evaluate
people
with
depressive
quickly.
Cognitive
impairment
core
characteristics
disorders,
which
great
value
in
identification
evaluation
disorders.
This
study
proposes
new
method
for
identifying
evaluating
based
on
cognitive
neurocomputing.
The
evaluates
impairments
such
as
reduced
attention,
executive
dysfunction,
slowed
information
processing
speed
that
may
exist
youth
disorder
population
through
an
independently
designed
digital
paradigm.
It
also
mines
biomarkers
can
effectively
these
impairments.
A
total
50
patients
47
healthy
controls
were
included
this
validate
method's
capability.
differences
analysis
results
showed
function
function,
extracted
significantly
different
between
controls.
Through
stepwise
regression
analysis,
four
finally
screened.
area
under
curve
them
jointly
distinguish
from
was
0.927.
rapidly
characterizes
quantifies
provides
way
organizations,
schools,
quickly
human-computer
interaction.
Язык: Английский
Longitudinal patterns of cognitive function and depression: insights from the China Health and Retirement Longitudinal Study
Journal of Global Health,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 28, 2025
Abstract
Background
With
the
acceleration
of
population
aging,
cognitive
impairment
and
depression
have
become
serious
public
health
challenges
in
countries
around
world.
The
influencing
factors
trajectory,
dual
trajectories
middle-aged
elderly
adults
not
been
fully
studied.
Methods
This
study
used
data
from
China
Health
Retirement
Longitudinal
Study
database
spanning
2011–2018.
Group-based
trajectory
modelling
group-based
were
employed
to
examine
different
trajectories.
Restricted
cubic
spline
multivariate
logistic
regression
analysis
elucidate
relationship
between
sleep
duration
grip
strength
with
these
Mediation
was
conducted
explore
mediating
roles
activities
daily
living
(ADLs)
their
impact
on
Results
Trajectory
identified
two
longitudinal
patterns
function
scores:
low
high
group,
respectively,
states
cognition
depression:
stable
state
group
decline
group.
Sleep
associated
has
an
inverted
U-shaped
trajectory.
Grip
nonlinearly
above
mediation
effects
association
ADLs
cognitive,
3.14,
6.14,
2.70%.
While
7.21,
1.67
6.24%,
respectively
(P
<
0.05).
Conclusions
only
depression,
trajectories,
but
also
partially
mediate
will
provide
a
basis
for
how
intervene
mental
adults.
Язык: Английский
Neuroplasticity in Depressive Disorders: The Role of BDNF in Linking Pharmacotherapy and Physical Activity
Maciej Mamczur,
Michał Szczepański,
Dominik Maciej Feret
и другие.
Quality in Sport,
Год журнала:
2024,
Номер
36, С. 56457 - 56457
Опубликована: Дек. 14, 2024
Introduction:
Depressive
disorders
are
among
the
most
prevalent
mental
health
conditions
globally,
affecting
millions
of
people.
Despite
extensive
research,
exact
pathophysiology
depression
remains
unclear.
Recent
evidence
suggests
that
neuroplasticity,
particularly
role
brain-derived
neurotrophic
factor
(BDNF),
plays
a
crucial
in
both
onset
and
treatment
depressive
disorders.
Aim
Study:
This
review
explores
relationship
between
neuroplasticity
depression,
focusing
on
BDNF
as
central
biomarker
potential
therapeutic
target.
It
also
examines
how
antidepressant
therapies
physical
activity
influence
levels,
offering
insights
into
novel
approaches
for
treating
Material
Methods:
A
literature
was
conducted
using
PubMed
Google
Scholar
databases,
peer-reviewed
articles
with
keywords:
"neuroplasticity",
"BDNF",
"depression",
"antidepressants"
"physical
activity".
Conclusions:
Neuroplasticity,
through
signaling,
critical
pathogenesis
depression.
Elevated
levels
promote
synaptic
plasticity,
neurogenesis,
recovery
brain
function.
Antidepressant
treatments
enhance
by
increasing
levels.
Antidepressants
neuroplastic
processes,
serving
key
mediator.
Язык: Английский