Potential intervention target of atherosclerosis: Ferroptosis (Review) DOI Creative Commons
Jia Li, Ling Xu, Yi Zuo

и другие.

Molecular Medicine Reports, Год журнала: 2022, Номер 26(5)

Опубликована: Сен. 21, 2022

Atherosclerosis (AS) is a chronic inflammatory disease of the blood vessels, which mainly characterized by form atherosclerotic plaques and vascular endothelial injury. Its formation involves abnormal lipid metabolism, oxidative stress inflammation, as well other processes. AS direct cause various acute cardiovascular cerebrovascular diseases, such myocardial infarction ischemic stroke. Early intervention in process lesion progression beneficial, has been associated with primary prevention range related diseases. Ferroptosis non‑apoptotic cell death different from necrosis autophagy, shown to participate atherogenesis through numerous signaling pathways. The main characteristic ferroptosis high levels cellular iron catalytic free radicals, unsaturated fatty acid accumulation iron‑induced reactive oxygen species accumulation, can stress, subsequent DNA, protein damage. There are hypotheses about pathogenesis AS. At present, it suggested that accelerate inflammation whole mechanisms pathways involvement neuroinflammation AS, therapeutic targets have not yet elucidated. present review article evaluated perspectives ferroptotic death, nervous system aim exploring new for

Язык: Английский

Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway DOI Creative Commons
Zhuang‐Hua Liu, Zhaopeng Zhou,

Pu Ai

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Авг. 19, 2022

Subarachnoid hemorrhage (SAH) is a severe type of stroke featuring exceptionally high rate morbidity and mortality due to the lack effective management. Ferroptosis can be defined as novel iron-dependent programmed cell death in contrast classical apoptosis necrosis. Astragaloside IV (AS-IV) an active ingredient extracted from Astragalus membranaceus with established therapeutic effect on CNS diseases. However, exact role ferroptosis IV-mediated neuroprotection after SAH yet demonstrated. In present study, model SD male rats endovascular perforation was used gauge neuroprotective AS-IV SAH-induced early brain injury (EBI) clarify potential molecular mechanism. We found that induction reduced levels SLC7A11 glutathione peroxidase 4 (GPX4) brain, exacerbated iron accumulation, enhanced lipid reactive oxygen species (ROS) level, stimulated neuronal ferroptosis. administration inhibitor Ferrostatin-1 (Fer-1) antioxidant capacity suppressed accumulation peroxides. Meanwhile, triggered Nrf2/HO-1 signaling pathway alleviated SAH. The Nrf2 ML385 blocked beneficial effects neuroprotection. These results consistently suggest profoundly implicated facilitating EBI SAH, thwarts process by activating pathway.

Язык: Английский

Процитировано

36

Targeting ferroptosis in ischemia/reperfusion renal injury DOI

Komal Thapa,

Thakur Gurjeet Singh,

Amarjot Kaur

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2022, Номер 395(11), С. 1331 - 1341

Опубликована: Авг. 3, 2022

Язык: Английский

Процитировано

35

Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis DOI Creative Commons

Chunkun Yang,

MU Yan-guang,

Shuanghong Li

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Дек. 1, 2023

Tanshinone IIA (Tan IIA) is a fat-soluble compound extracted from Salvia miltiorrhiza, which has protective effect against atherosclerosis (AS). Tan can inhibit oxidative stress and inflammatory damage of vascular endothelial cells (VECs) improve cell dysfunction. also good on smooth muscle (VSMCs). It reduce stenosis by inhibiting the proliferation migration (VSMCs), stability fibrous cap atherosclerotic plaque apoptosis inflammation VSMCs. In addition, inhibits response macrophages formation foam in plaques. summary, improves AS through complex pathway. We propose to further study specific molecular targets using systems biology methods, so as fundamentally elucidate mechanism IIA. worth mentioning that there lack high-quality evidence-based medical data treatment AS. recommend randomized controlled clinical trial be conducted evaluate exact efficacy improving Finally, sodium tanshinone sulfonate (STS) cause adverse drug reactions some patients, needs our attention.

Язык: Английский

Процитировано

19

Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug DOI Creative Commons
Hu Li,

Pengbo Hu,

Yajun Zou

и другие.

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Янв. 31, 2023

Because of its high prevalence and poor long-term clinical treatment effect, liver disease is regarded as a major public health problem around the world. Among them, viral hepatitis, fatty liver, cirrhosis, non-alcoholic (NAFLD), autoimmune are common causes inducements injury, play an important role in occurrence development hepatocellular carcinoma (HCC). Tanshinone IIA (TsIIA) fat soluble polyphenol Salvia miltiorrhiza that extracted from miltiorrhiza. strong biological activity (anti-inflammatory, antioxidant), it widely used Asia to treat cardiovascular diseases. In addition, TsIIA has shown significant anti-HCC previous studies. It not only anti proliferation pro apoptotic properties. can also anti-cancer by mediating variety signal pathways, including phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/rapamycin (mTOR), mitogen-activated protein (MAPK), nuclear factor kappa-B (NF-κB). This review reviews existing evidence molecular mechanism TsIIA's effect but liver-protective impact on fibrosis, NAFLD, other risk factors for cancer. we conducted network pharmacological analysis HCC further screen explore possible targets against carcinoma. expected provide theoretical basis anti-HCC-related drugs based TsIIA.

Язык: Английский

Процитировано

18

The role of ferroptosis in metabolic diseases DOI Creative Commons
Ling Xie, Bin Fang, Chun Zhang

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2023, Номер 1870(6), С. 119480 - 119480

Опубликована: Апрель 30, 2023

Язык: Английский

Процитировано

18

Herbal medicines provide regulation against iron overload in cardiovascular diseases: Informing future applications DOI
Jia Liu,

Liangyan Deng,

Liping Qu

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 326, С. 117941 - 117941

Опубликована: Фев. 20, 2024

Язык: Английский

Процитировано

9

Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway DOI Creative Commons
Shuai Zhu, Zhiqiang Kang, Fengjiao Zhang

и другие.

Journal of Diabetes Investigation, Год журнала: 2024, Номер 15(8), С. 1003 - 1016

Опубликована: Апрель 22, 2024

Tanshinone IIA (TIIA) is one of the main components root red-rooted Salvia miltiorrhiza Bunge. However, molecular mechanisms underlying TIIA-mediated protective effects in diabetic nephropathy (DN) are still unclear.

Язык: Английский

Процитировано

8

Qishen granule alleviates doxorubicin-induced cardiotoxicity by suppressing ferroptosis via nuclear erythroid factor 2-related factor 2 (Nrf2) pathway DOI
Siming Xue, Huan Chen, Jingmei Zhang

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 335, С. 118604 - 118604

Опубликована: Июль 22, 2024

Язык: Английский

Процитировано

8

Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma DOI Open Access
Wei Mao, Jian Ding, Yu Li

и другие.

Experimental and Therapeutic Medicine, Год журнала: 2022, Номер 24(2)

Опубликована: Июнь 16, 2022

Head and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence increasing it now the sixth most common cancer type worldwide. As indicated by existing studies, ferroptosis contributes to HNSCC progression Tanshinone IIA (TanIIA) may exert therapeutic effects via affecting ferroptosis. However, underlying mechanisms have remained be clarified. Therefore, main aim of present study was screen investigate key genes in regulating human hypopharynx line FaDu further elucidate mechanism action TanIIA. A list ferroptosis‑related obtained from FerrDb database. RNA‑sequencing expression (level 3) profiles corresponding clinical information (cases, n=502; normal controls, n=44) were downloaded The Cancer Genome Atlas dataset for (https://portal.gdc.com). limma package R software used differentially expressed mRNAs. Adjusted P<0.05 Log2(fold change) >1 or <‑1 defined as threshold differential ClusterProfiler (version 3.18.0) employed analyze Gene Ontology functional terms associated with potential targets perform Kyoto Encyclopedia Genes Genomes pathway analysis. ggplot2 draw boxplot pheatmap heatmap. DEG‑related protein‑protein interaction network built Search Tool Retrieval Interacting proteins database then visualization performed using Cytoscape. Ferritin heavy chain 1 (FTH1), transferrin (TF) TF receptor screened out Wayne diagram, which drawn Venn Diagram R. Kaplan‑Meier survival analysis log‑rank test compare differences between groups. receiver operating characteristic (v 0.4) (ROC) curve predictive accuracy FTH1 results verified Human Protein data. Immunohistochemistry immunofluorescence localize cells. Furthermore, Cell Counting Kit‑8 Transwell assays detect invasion ability, respectively. western blot protein expression. that three validated marker HNSCC, among significantly poorer survival. TanIIA demonstrated affect invasiveness markedly attenuate To conclude, gene highly inhibited partially suppressing FTH1.

Язык: Английский

Процитировано

28

A Pharmacological Review of Tanshinones, Naturally Occurring Monomers from Salvia miltiorrhiza for the Treatment of Cardiovascular Diseases DOI Creative Commons
Ye Yang, Mingyan Shao,

Wenkun Cheng

и другие.

Oxidative Medicine and Cellular Longevity, Год журнала: 2023, Номер 2023, С. 1 - 24

Опубликована: Фев. 6, 2023

Cardiovascular diseases (CVDs) are a set of heart and blood vessel disorders that include coronary disease (CHD), rheumatic disease, other conditions. Traditional Chinese Medicine (TCM) has definite effects on CVDs due to its multitarget multicomponent properties, which gradually gaining national attention. Tanshinones, the major active chemical compounds extracted from Salvia miltiorrhiza, exhibit beneficial improvement multiple diseases, especially CVDs. At level biological activities, they play significant roles, including anti-inflammation, anti-oxidation, anti-apoptosis anti-necroptosis, anti-hypertrophy, vasodilation, angiogenesis, combat against proliferation migration smooth muscle cells (SMCs), as well anti-myocardial fibrosis ventricular remodeling, all effective strategies in preventing treating Additionally, at cellular level, Tanshinones produce marked cardiomyocytes, macrophages, endothelia, SMCs, fibroblasts myocardia. In this review, we have summarized brief overview structures pharmacological CVD treatment expound different properties various cell types

Язык: Английский

Процитировано

17