Molecular Medicine Reports,
Год журнала:
2022,
Номер
26(5)
Опубликована: Сен. 21, 2022
Atherosclerosis
(AS)
is
a
chronic
inflammatory
disease
of
the
blood
vessels,
which
mainly
characterized
by
form
atherosclerotic
plaques
and
vascular
endothelial
injury.
Its
formation
involves
abnormal
lipid
metabolism,
oxidative
stress
inflammation,
as
well
other
processes.
AS
direct
cause
various
acute
cardiovascular
cerebrovascular
diseases,
such
myocardial
infarction
ischemic
stroke.
Early
intervention
in
process
lesion
progression
beneficial,
has
been
associated
with
primary
prevention
range
related
diseases.
Ferroptosis
non‑apoptotic
cell
death
different
from
necrosis
autophagy,
shown
to
participate
atherogenesis
through
numerous
signaling
pathways.
The
main
characteristic
ferroptosis
high
levels
cellular
iron
catalytic
free
radicals,
unsaturated
fatty
acid
accumulation
iron‑induced
reactive
oxygen
species
accumulation,
can
stress,
subsequent
DNA,
protein
damage.
There
are
hypotheses
about
pathogenesis
AS.
At
present,
it
suggested
that
accelerate
inflammation
whole
mechanisms
pathways
involvement
neuroinflammation
AS,
therapeutic
targets
have
not
yet
elucidated.
present
review
article
evaluated
perspectives
ferroptotic
death,
nervous
system
aim
exploring
new
for
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 19, 2022
Subarachnoid
hemorrhage
(SAH)
is
a
severe
type
of
stroke
featuring
exceptionally
high
rate
morbidity
and
mortality
due
to
the
lack
effective
management.
Ferroptosis
can
be
defined
as
novel
iron-dependent
programmed
cell
death
in
contrast
classical
apoptosis
necrosis.
Astragaloside
IV
(AS-IV)
an
active
ingredient
extracted
from
Astragalus
membranaceus
with
established
therapeutic
effect
on
CNS
diseases.
However,
exact
role
ferroptosis
IV-mediated
neuroprotection
after
SAH
yet
demonstrated.
In
present
study,
model
SD
male
rats
endovascular
perforation
was
used
gauge
neuroprotective
AS-IV
SAH-induced
early
brain
injury
(EBI)
clarify
potential
molecular
mechanism.
We
found
that
induction
reduced
levels
SLC7A11
glutathione
peroxidase
4
(GPX4)
brain,
exacerbated
iron
accumulation,
enhanced
lipid
reactive
oxygen
species
(ROS)
level,
stimulated
neuronal
ferroptosis.
administration
inhibitor
Ferrostatin-1
(Fer-1)
antioxidant
capacity
suppressed
accumulation
peroxides.
Meanwhile,
triggered
Nrf2/HO-1
signaling
pathway
alleviated
SAH.
The
Nrf2
ML385
blocked
beneficial
effects
neuroprotection.
These
results
consistently
suggest
profoundly
implicated
facilitating
EBI
SAH,
thwarts
process
by
activating
pathway.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 1, 2023
Tanshinone
IIA
(Tan
IIA)
is
a
fat-soluble
compound
extracted
from
Salvia
miltiorrhiza,
which
has
protective
effect
against
atherosclerosis
(AS).
Tan
can
inhibit
oxidative
stress
and
inflammatory
damage
of
vascular
endothelial
cells
(VECs)
improve
cell
dysfunction.
also
good
on
smooth
muscle
(VSMCs).
It
reduce
stenosis
by
inhibiting
the
proliferation
migration
(VSMCs),
stability
fibrous
cap
atherosclerotic
plaque
apoptosis
inflammation
VSMCs.
In
addition,
inhibits
response
macrophages
formation
foam
in
plaques.
summary,
improves
AS
through
complex
pathway.
We
propose
to
further
study
specific
molecular
targets
using
systems
biology
methods,
so
as
fundamentally
elucidate
mechanism
IIA.
worth
mentioning
that
there
lack
high-quality
evidence-based
medical
data
treatment
AS.
recommend
randomized
controlled
clinical
trial
be
conducted
evaluate
exact
efficacy
improving
Finally,
sodium
tanshinone
sulfonate
(STS)
cause
adverse
drug
reactions
some
patients,
needs
our
attention.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 31, 2023
Because
of
its
high
prevalence
and
poor
long-term
clinical
treatment
effect,
liver
disease
is
regarded
as
a
major
public
health
problem
around
the
world.
Among
them,
viral
hepatitis,
fatty
liver,
cirrhosis,
non-alcoholic
(NAFLD),
autoimmune
are
common
causes
inducements
injury,
play
an
important
role
in
occurrence
development
hepatocellular
carcinoma
(HCC).
Tanshinone
IIA
(TsIIA)
fat
soluble
polyphenol
Salvia
miltiorrhiza
that
extracted
from
miltiorrhiza.
strong
biological
activity
(anti-inflammatory,
antioxidant),
it
widely
used
Asia
to
treat
cardiovascular
diseases.
In
addition,
TsIIA
has
shown
significant
anti-HCC
previous
studies.
It
not
only
anti
proliferation
pro
apoptotic
properties.
can
also
anti-cancer
by
mediating
variety
signal
pathways,
including
phosphatidylinositol-3-kinase
(PI3K)/protein
kinase
B
(Akt)/rapamycin
(mTOR),
mitogen-activated
protein
(MAPK),
nuclear
factor
kappa-B
(NF-κB).
This
review
reviews
existing
evidence
molecular
mechanism
TsIIA's
effect
but
liver-protective
impact
on
fibrosis,
NAFLD,
other
risk
factors
for
cancer.
we
conducted
network
pharmacological
analysis
HCC
further
screen
explore
possible
targets
against
carcinoma.
expected
provide
theoretical
basis
anti-HCC-related
drugs
based
TsIIA.
Journal of Diabetes Investigation,
Год журнала:
2024,
Номер
15(8), С. 1003 - 1016
Опубликована: Апрель 22, 2024
Tanshinone
IIA
(TIIA)
is
one
of
the
main
components
root
red-rooted
Salvia
miltiorrhiza
Bunge.
However,
molecular
mechanisms
underlying
TIIA-mediated
protective
effects
in
diabetic
nephropathy
(DN)
are
still
unclear.
Experimental and Therapeutic Medicine,
Год журнала:
2022,
Номер
24(2)
Опубликована: Июнь 16, 2022
Head
and
neck
squamous
cell
carcinoma
(HNSCC)
is
a
worldwide
public
health
problem;
its
incidence
increasing
it
now
the
sixth
most
common
cancer
type
worldwide.
As
indicated
by
existing
studies,
ferroptosis
contributes
to
HNSCC
progression
Tanshinone
IIA
(TanIIA)
may
exert
therapeutic
effects
via
affecting
ferroptosis.
However,
underlying
mechanisms
have
remained
be
clarified.
Therefore,
main
aim
of
present
study
was
screen
investigate
key
genes
in
regulating
human
hypopharynx
line
FaDu
further
elucidate
mechanism
action
TanIIA.
A
list
ferroptosis‑related
obtained
from
FerrDb
database.
RNA‑sequencing
expression
(level
3)
profiles
corresponding
clinical
information
(cases,
n=502;
normal
controls,
n=44)
were
downloaded
The
Cancer
Genome
Atlas
dataset
for
(https://portal.gdc.com).
limma
package
R
software
used
differentially
expressed
mRNAs.
Adjusted
P<0.05
Log2(fold
change)
>1
or
<‑1
defined
as
threshold
differential
ClusterProfiler
(version
3.18.0)
employed
analyze
Gene
Ontology
functional
terms
associated
with
potential
targets
perform
Kyoto
Encyclopedia
Genes
Genomes
pathway
analysis.
ggplot2
draw
boxplot
pheatmap
heatmap.
DEG‑related
protein‑protein
interaction
network
built
Search
Tool
Retrieval
Interacting
proteins
database
then
visualization
performed
using
Cytoscape.
Ferritin
heavy
chain
1
(FTH1),
transferrin
(TF)
TF
receptor
screened
out
Wayne
diagram,
which
drawn
Venn
Diagram
R.
Kaplan‑Meier
survival
analysis
log‑rank
test
compare
differences
between
groups.
receiver
operating
characteristic
(v
0.4)
(ROC)
curve
predictive
accuracy
FTH1
results
verified
Human
Protein
data.
Immunohistochemistry
immunofluorescence
localize
cells.
Furthermore,
Cell
Counting
Kit‑8
Transwell
assays
detect
invasion
ability,
respectively.
western
blot
protein
expression.
that
three
validated
marker
HNSCC,
among
significantly
poorer
survival.
TanIIA
demonstrated
affect
invasiveness
markedly
attenuate
To
conclude,
gene
highly
inhibited
partially
suppressing
FTH1.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2023,
Номер
2023, С. 1 - 24
Опубликована: Фев. 6, 2023
Cardiovascular
diseases
(CVDs)
are
a
set
of
heart
and
blood
vessel
disorders
that
include
coronary
disease
(CHD),
rheumatic
disease,
other
conditions.
Traditional
Chinese
Medicine
(TCM)
has
definite
effects
on
CVDs
due
to
its
multitarget
multicomponent
properties,
which
gradually
gaining
national
attention.
Tanshinones,
the
major
active
chemical
compounds
extracted
from
Salvia
miltiorrhiza,
exhibit
beneficial
improvement
multiple
diseases,
especially
CVDs.
At
level
biological
activities,
they
play
significant
roles,
including
anti-inflammation,
anti-oxidation,
anti-apoptosis
anti-necroptosis,
anti-hypertrophy,
vasodilation,
angiogenesis,
combat
against
proliferation
migration
smooth
muscle
cells
(SMCs),
as
well
anti-myocardial
fibrosis
ventricular
remodeling,
all
effective
strategies
in
preventing
treating
Additionally,
at
cellular
level,
Tanshinones
produce
marked
cardiomyocytes,
macrophages,
endothelia,
SMCs,
fibroblasts
myocardia.
In
this
review,
we
have
summarized
brief
overview
structures
pharmacological
CVD
treatment
expound
different
properties
various
cell
types
