Nutrients,
Год журнала:
2022,
Номер
14(21), С. 4506 - 4506
Опубликована: Окт. 26, 2022
Endothelial
cells
(ECs)
line
the
inner
surface
of
blood
vessels
and
play
a
substantial
role
in
vascular
biology.
dysfunction
(ED)
is
strongly
correlated
with
initiation
progression
many
diseases.
Regulated
cell
death,
such
as
ferroptosis,
one
multiple
mechanisms
that
lead
to
ED.
Ferroptosis
an
iron-dependent
programmed
death
associated
various
diseases,
cardiovascular,
cerebrovascular,
pulmonary
This
review
summarized
ferroptosis
ECs
diseases
discussed
potential
therapeutic
strategies
for
treating
ECs.
In
addition
lipid
peroxidation
inhibitors
iron
chelators,
growing
body
evidence
showed
clinical
drugs,
natural
products,
intervention
noncoding
RNAs
may
also
inhibit
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115086 - 115086
Опубликована: Июль 6, 2023
Diabetic
nephropathy
(DN)
is
one
of
the
main
complications
diabetes.
However,
effective
therapy
to
block
or
slow
down
progression
DN
still
lacking.
San-Huang-Yi-Shen
capsule
(SHYS)
has
been
shown
significantly
improve
renal
function
and
delay
DN.
mechanism
SHYS
on
unclear.
In
this
study,
we
established
a
mouse
model
Then,
investigated
anti-ferroptotic
effects
including
reduction
iron
overload
activation
cystine/GSH/GPX4
axis.
Finally,
used
GPX4
inhibitor
(RSL3)
ferroptosis
(ferrostatin-1)
determine
whether
ameliorates
through
inhibiting
ferroptosis.
The
results
showed
that
treatment
was
for
mice
with
in
terms
improving
function,
reducing
inflammation
oxidative
stress.
Besides,
reduced
upregulated
expression
axis-related
factors
kidney.
Moreover,
exhibited
similar
therapeutic
effect
as
ferrostatin-1,
RSL3
could
abolish
anti-
ferroptotic
conclusion,
can
be
treat
Furthermore,
inhibit
upregulating
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
173, С. 116356 - 116356
Опубликована: Фев. 29, 2024
Aging,
an
inevitable
aspect
of
human
existence,
serves
as
one
the
predominant
risk
factors
for
vascular
diseases.
Delving
into
mystery
disease's
pathophysiology,
profound
involvement
programmed
cell
death
(PCD)
has
been
extensively
demonstrated.
PCD
is
a
fundamental
biological
process
that
plays
crucial
role
in
both
normal
physiology
and
pathology,
including
recently
discovered
form,
ferroptosis.
Ferroptosis
characterized
by
its
reliance
on
iron
lipid
peroxidation,
significant
disease
pathophysiology
increasingly
acknowledged.
This
phenomenon
not
only
offers
promising
therapeutic
target
but
also
deepens
our
understanding
complex
relationship
between
ferroptosis
age-related
Consequently,
this
article
aims
to
thoroughly
review
mechanisms
enable
effective
control
inhibition
It
focuses
genetic
pharmacological
interventions,
with
goal
developing
innovative
strategies
combat
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117183 - 117183
Опубликована: Июль 30, 2024
Atherosclerosis,
characterized
by
the
accumulation
of
plaque
within
arterial
walls,
is
an
intricate
cardiovascular
disease
that
often
results
in
severe
health
issues.
Recent
studies
have
emphasized
importance
ferroptosis,
a
controlled
type
cell
death
dependent
on
iron,
as
critical
factor
this
state.
Ferroptosis,
distinguished
its
reliance
iron
and
lipid
hydroperoxides,
offers
unique
insight
into
pathology
atherosclerotic
lesions.
This
summary
encapsulates
current
knowledge
role
ferroptosis
plays
onset
progression
atherosclerosis.
It
explores
molecular
processes
through
which
peroxidation
metabolism
contribute
to
development
atheromatous
plaques
evaluates
possibility
utilizing
novel
treatment
approach
for
By
illuminating
relationship
between
ferroptosis-related
atherosclerosis,
review
paves
way
future
clinical
applications
personalized
medicine
approaches
aimed
at
alleviating
effects
Acta Biochimica et Biophysica Sinica,
Год журнала:
2023,
Номер
55(9), С. 1337 - 1347
Опубликована: Июнь 16, 2023
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death,
results
in
lipid
peroxidation
polyunsaturated
fatty
acids
the
membrane,
which
is
catalyzed
by
iron
ions
and
accumulated
to
lethal
levels.
It
mechanistically
distinct
from
other
forms
such
as
apoptosis,
pyroptosis,
necroptosis,
so
it
may
address
problem
cancer
resistance
apoptosis
provide
new
therapeutic
strategies
for
treatment,
has
been
intensively
studied
over
past
few
years.
Notably,
considerable
advances
have
made
antitumor
research
natural
products
due
their
multitargets
side
effects.
According
research,
can
also
induce
ferroptosis
therapies.
In
this
review
we
summarize
molecular
mechanisms
ferroptosis,
introduce
key
regulatory
genes
discuss
progress
product
field
theoretical
guidance
on
product-induced
tumors.
Nutrients,
Год журнала:
2022,
Номер
14(21), С. 4506 - 4506
Опубликована: Окт. 26, 2022
Endothelial
cells
(ECs)
line
the
inner
surface
of
blood
vessels
and
play
a
substantial
role
in
vascular
biology.
dysfunction
(ED)
is
strongly
correlated
with
initiation
progression
many
diseases.
Regulated
cell
death,
such
as
ferroptosis,
one
multiple
mechanisms
that
lead
to
ED.
Ferroptosis
an
iron-dependent
programmed
death
associated
various
diseases,
cardiovascular,
cerebrovascular,
pulmonary
This
review
summarized
ferroptosis
ECs
diseases
discussed
potential
therapeutic
strategies
for
treating
ECs.
In
addition
lipid
peroxidation
inhibitors
iron
chelators,
growing
body
evidence
showed
clinical
drugs,
natural
products,
intervention
noncoding
RNAs
may
also
inhibit
