Reductive stress: The key pathway in metabolic disorders induced by overnutrition

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The balance of redox states is crucial for maintaining physiological homeostasis. For decades, the focus has been mainly on concept oxidative stress, which involved in mechanism almost all diseases. However, robust evidence highlighted that reductive other side spectrum, plays a pivotal role development various diseases, particularly those related to metabolism and cardiovascular health. In this review, we present an extensive array occurrence stress its significant implications metabolic Reductive defined as shift cellular towards more reduced state, characterized by excess endogenous reductants (such NADH, NADPH, GSH) over their oxidized counterparts (NAD+, NADP+, GSSG). While predominant studied obesity, disorders, growing underscores critical stress. This review discusses how contributes pathologies, emphasizing effects key processes. example, excessive NADH accumulation can disrupt mitochondrial function impairing electron transport chain, leading decreased ATP production increased reactive oxygen species. endoplasmic reticulum (ER), equivalents hampers protein folding, triggering ER activating unfolded response, lead insulin resistance compromised Furthermore, explore antioxidant supplementation exacerbate further shifting balance, potentially undermining beneficial exercise, health, aggravating obese individuals. body calls reevaluation disease pathogenesis therapeutic interventions.

Язык: Английский

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Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 9, 2025

Язык: Английский

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A Platelet-Powered Drug Delivery System for Enhancing Chemotherapy Efficacy for Liver Cancer Using the Trojan Horse Strategy

Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 905 - 905

Опубликована: Июль 5, 2024

Optimizing the delivery and penetration of nano-sized drugs within liver cancer sites, along with remodeling tumor microenvironment, is crucial for enhancing efficacy chemotherapeutic agents. For this study, a platelet (PLT)-mediated nanodrug system (DASA+ATO@PLT) was developed to improve effectiveness chemotherapy. This delivers dasatinib atovaquone specifically sites facilitates intra-tumoral permeation upon release. Through JC-1, immunohistochemistry, DNA damage analyses, therapeutic effect DASA+ATO@PLT assessed. In vitro simulation intravital imaging were carried out determine accumulation in sites. The experiment demonstrated followed by deep microenvironment assistance PLTs, while simultaneously revealing ability remodel (overcoming hypoxia) enhance efficacy. utilizes natural recognition PLTs enhances chemo-immunotherapeutic through targeted nano-chemotherapeutic tumor, resulting effective infiltration. PLT-mediated serves as "Trojan horse" carry cargo deliver them target cells, leading favorable outcomes.

Язык: Английский

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Ndufa8 promotes white fat Browning by improving mitochondrial respiratory chain complex I function to ameliorate obesity by in vitro and in vivo

Cellular Signalling, Год журнала: 2024, Номер 122, С. 111340 - 111340

Опубликована: Авг. 8, 2024

Язык: Английский

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