Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome

Chinese Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Фев. 5, 2025

Язык: Английский

---

Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Окт. 26, 2024

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein crucial for cellular stress response and survival, particularly in the nervous cardiovascular systems. Unlike traditional factors, MANF primarily regulates endoplasmic reticulum (ER) protects cells by reducing ER stress-induced apoptosis. operates both inside outside cells, influencing key pathways like JAK/STAT NF-κB to enhance cell survival during stress. Beyond its neuroprotective role, also vital protection, mitigating damage inflammation maintaining function. Elevated levels have been observed patients experiencing myocardial infarction murine models of ischemia-reperfusion (I/R) injury, highlighting importance these conditions. Overexpression cardiomyocytes reduces ER-stress-induced death, while depletion worsens this effect. Treatment with recombinant (rMANF) has shown improve cardiac function mice I/R injury decreasing infarct size inflammation. Research indicates that alterations α1-helix region can impact structure, expression, secretion, overall Given protective effects involvement critical signaling pathways, being explored as potential therapeutic target stress-related diseases, including neurodegenerative disorders conditions injury.

Язык: Английский

---

Altered GnRH neuron-glia networks close to interface of polycystic ovary syndrome: Molecular mechanism and clinical perspectives

Life Sciences, Год журнала: 2024, Номер unknown, С. 123318 - 123318

Опубликована: Дек. 1, 2024

Язык: Английский

---