Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116667 - 116667
Опубликована: Дек. 1, 2024
Язык: Английский
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 7, 2025
Liver transplantation is the most effective treatment for end-stage liver disease. However, shortage of donor livers has become a significant obstacle to advancement transplantation. Mesenchymal stem cells-derived exosomes (MSCs-Exo) have been extensively investigated in diseases. underlying mechanisms how they can protect organ donation after cardiac death (DCD) remain unclear. In this study, an arterialized mouse non-heart-beating (NHB) model was used investigate effect MSCs-Exo on NHB The survival rates, histology, pro-inflammatory cytokine and chemokine expression, were investigated. infusion reduced injury DCD graft tissue. vitro vivo experiments demonstrated that could inhibit hydrogen peroxide-induced pyroptosis Kupffer cells. We found miR-17-5p significantly abundant MSCs-Exo, targeting regulating TXNIP expression. This action inhibited NLRP3-mediated cells through classical Caspase1-dependent pathway, alleviating injury. Our study elucidated protective role model. mechanism provides theoretical basis new strategies clinical application improve quality alleviate
Язык: Английский
Процитировано
2
Journal of Food Biochemistry, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Our preliminary investigation has unveiled that emodin may inhibit the neurotoxic effects of sodium fluoride (NaF) on SH‐SY5Y cells by deactivating ERK and activating Nrf2/HO‐1 signaling pathway. This action thereby restores synaptic damage reduces excessive reactive oxygen species (ROS) generation. To delve further into neuroprotective neuronal cells, our study revealed 48 h NaF treatment disrupted balance between mitochondrial fission fusion in cells. disruption significantly upregulated proteins associated with pyroptosis pathways, including NLRP3, Caspase‐1, IL‐1 β , GSDMD expression, while inhibiting NF‐ κ B phosphorylation. Notably, pretreatment effectively reinstated these alterations induced exposure, indicating its capacity to not only mitigate ROS production but also regulate dynamics pathways. counteraction toxic provides valuable insights role emodin.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 7, 2025
Pancreatic cancer is renowned for its aggressive nature and dismal prognosis, with the majority of patients diagnosed at an advanced stage. The prognosis pancreatic can be improved by early diagnosis effective treatment. Circulating cell-free DNA (cfDNA) has emerged as a promising biomarker monitoring cancer. This research presents review circulating essential role in immunotherapy detection methods cfDNA, potential diagnostic biomarker, latest progress cfDNA-based are discussed. findings suggest that cfDNA plays vital personalised treatment cancer, holding great promise improving patient outcomes.
Язык: Английский
Процитировано
0
Data in Brief, Год журнала: 2025, Номер unknown, С. 111503 - 111503
Опубликована: Март 1, 2025
In this work, seven Cylo phe-Ala-Asp-Gly-based Compounds were optimized using Spartan'14 software. Series of software used in work Spartan 14, molecular operating environment (MOE), padel, ADMET. The compounds docked against human Caspase 1 (6F6R) so as to observe their inhibiting ability. calculated descriptors for individual reported and described. Also, the compound 2 (2-((2S,8S,11S)-11-([1,1'-biphenyl]-4-ylmethyl)-8-benzyl-3,6,9,12-tetraoxo-1,4,7,10-tetraazacyclododecan-2-yl) acetic acid) proved be more efficient caspase than other under investigation. pharmacokinetic evaluation with highest binding affinity reference executed reported.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 28, 2025
Sepsis is defined as a condition related to infection that manifests with multiorgan dysfunction, representing life-threatening state. Consequently, severe complications frequently occur, liver injury being one of the most prevalent serious sepsis. Liver dysfunction during sepsis serves an independent predictor mortality. This review provides comprehensive overview current research on sepsis-induced (SILI), encompassing clinical manifestations, diagnostic criteria, pathogenesis and therapeutic strategies associated this condition. SILI may manifest hypoxic hepatitis due ischemia shock, cholestasis resulting from abnormal bile metabolism, or duct sclerosis. The pathophysiology involves intricate interactions among inflammatory response, oxidative stress, cell death. All these factors complicate treatment represent potential targets for intervention. Furthermore, addresses limitations inherent in conventional therapies currently employed managing emphasizes novel targeted aimed at addressing fundamental mechanisms underlying
Язык: Английский
Процитировано
0
Neurotherapeutics, Год журнала: 2025, Номер unknown, С. e00572 - e00572
Опубликована: Апрель 1, 2025
Retinoic acid-inducible gene-I (RIG-I) is an immune signal that promotes inflammatory responses and plays important role in endothelial cell-mediated inflammation. Currently, no studies have investigated the of RIG-I early brain injury (EBI) after subarachnoid hemorrhage (SAH). In this research, vivo SAH model was established Sprague Dawley (SD) rats through carotid artery puncture, while oxyhemoglobin (OxyHb) used to stimulate microvascular cells (BMVECs) generate vitro model. The results showed activated expressed BMVECs both vitro. To explore how involved EBI, small interfering RNA downregulate its expression. Compared with rats, knockdown had better short-term long-term neurological recovery SAH, milder edema neurodegeneration, weaker blood-brain barrier disruption neuroinflammation. Furthermore, attenuated SAH-induced pyroptosis. OxyHb-stimulated BMVECs, reduced cellular dysfunction determine mechanism pyroptosis, co-immunoprecipitation verify direct binding caspase-1, could reduce Oxy-Hb-induced caspase-1 inhibitor VX-765 can alleviate tight junction loss, inflammation pyroptosis exacerbated by agonist. addition, levels cerebrospinal fluid patients were higher than those controls correlated factors clinical outcomes. summary, demonstrated aggravates neuroinflammation promoting caspase-1-mediated
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Microbial Pathogenesis, Год журнала: 2024, Номер 197, С. 107014 - 107014
Опубликована: Окт. 11, 2024
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138035 - 138035
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116667 - 116667
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1