Ferroptosis in NAFLD: insights and the therapeutic potential of exercise DOI Creative Commons
Chang Li, Dehui Deng,

Qingfeng Jiang

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 26, 2025

Ferroptosis, a distinct form of non-apoptotic cell death driven by iron accumulation, has garnered significant attention in recent years. Emerging evidence suggests that ferroptosis hepatocytes may serve as pivotal trigger the pathogenesis non-alcoholic fatty liver disease (NAFLD). Importantly, inhibiting shown promising potential slowing progression NAFLD. Concurrently, exercise, cornerstone prevention and management chronic diseases, plays critical role regulating progression. As such, modulation through exercise represents avenue for developing innovative therapeutic strategies. This review aims to systematically elucidate conceptual framework molecular mechanisms underlying ferroptosis, with particular emphasis on its pathophysiological We have summarized effects regulation multiple mechanisms, including upregulation antioxidant defense systems via activation NRF2, GPX4, SLC7A11 signaling pathways; metabolism FPN-mediated homeostasis regulation. These findings not only provide valuable insights into basis exercise-induced protection against ferroptosis-mediated cellular damage but also offer novel perspectives future investigations exercise-based interventions NAFLD management. work thereby contributes advancement strategies field metabolic diseases.

Язык: Английский

Gentisic Acid Protects Sprague-Dawley Rats from Myocardial Infarction through Reversing Electrocardiographical, Biochemical and Histopathological Abnormalities DOI
Aimen Sajid, Muhammad Ikram, Nabi Shah

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 749, С. 151349 - 151349

Опубликована: Янв. 17, 2025

Язык: Английский

Процитировано

0
Ferroptosis in NAFLD: insights and the therapeutic potential of exercise DOI Creative Commons
Chang Li, Dehui Deng,

Qingfeng Jiang

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 26, 2025

Ferroptosis, a distinct form of non-apoptotic cell death driven by iron accumulation, has garnered significant attention in recent years. Emerging evidence suggests that ferroptosis hepatocytes may serve as pivotal trigger the pathogenesis non-alcoholic fatty liver disease (NAFLD). Importantly, inhibiting shown promising potential slowing progression NAFLD. Concurrently, exercise, cornerstone prevention and management chronic diseases, plays critical role regulating progression. As such, modulation through exercise represents avenue for developing innovative therapeutic strategies. This review aims to systematically elucidate conceptual framework molecular mechanisms underlying ferroptosis, with particular emphasis on its pathophysiological We have summarized effects regulation multiple mechanisms, including upregulation antioxidant defense systems via activation NRF2, GPX4, SLC7A11 signaling pathways; metabolism FPN-mediated homeostasis regulation. These findings not only provide valuable insights into basis exercise-induced protection against ferroptosis-mediated cellular damage but also offer novel perspectives future investigations exercise-based interventions NAFLD management. work thereby contributes advancement strategies field metabolic diseases.

Язык: Английский

Процитировано

0