Serum homocysteine showed potential association with cognition and abnormal gut microbiome in major depressive disorder
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(3)
Опубликована: Фев. 26, 2025
Cognitive
impairment
is
one
of
the
common
clinical
manifestations
depression,
causing
negative
distress
to
patients.
Elevated
homocysteine
(Hcy)
concentrations
and
gut
microbiome
dysfunction
may
be
observed
in
patients
with
depression.
To
investigate
relationship
between
Hcy,
microbiome,
cognition
depressive
We
recruited
67
major
disorder
(MDD)
(MDD
group)
94
healthy
controls
(HCs)
individuals
(HCs
group).
Serum
Hcy
levels
were
determined
using
enzyme
circulation
method.
16s
rRNA
sequencing
was
used
classify
identify
fecal
bacteria.
17
Hamilton
depression
rating
scale
MATRICS
consensus
cognitive
battery
evaluate
mood
states
MDD.
Correlation
analysis
performed
explore
correlation
flora,
function.
serum
seen
MDD
compared
individuals.
Patients
indicated
significant
decreases
scores
(P
<
0.001)
six
modules:
Speed
processing,
working
memory,
visual
learning,
reasoning
problem-solving,
social
cognition,
total
scores.
showed
a
processing
speed,
0.05).
also
significantly
negatively
correlated
Alistipes,
Ruminococcae,
Tenericides,
Porphyromonas
Our
results
highlight
that
This
interaction
related
physiological
pathological
mechanisms
underlying
deficits
Язык: Английский
Flammulina velutipes residue Polysaccharide Alleviates Immunosuppression and Intestinal Injury by Modulating Gut Microbiota and Associated Metabolites
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
This
study
elucidated
the
mechanisms
underlying
immunoregulatory
and
gut-microbiota-modulating
effects
of
Flammulina
velutipes
residue
polysaccharide
(FVRP)
using
cyclophosphamide
(CTX)-induced
mouse
models.
FVRP
supplementation
alleviated
CTX-induced
intestinal
damage
boosted
antioxidant
enzyme
activity
cytokine
secretion.
Additionally,
enhanced
diversity
total
species
richness
gut
microbiota,
promoting
proliferation
beneficial
bacteria
(e.g.,
Prevotellaceae),
while
reducing
abundance
CTX-derived
(Lachnospiraceae
Rikenellaceae).
facilitates
accumulation
short-chain
fatty
acids.
Untargeted
metabolomic
analyses
cecal
content
revealed
that
treatment
notably
restored
levels
32
endogenous
metabolites
altered
by
CTX.
Based
on
a
pseudosterility
mice
model,
fecal
microbiota
transplantation
(FMT),
filtrate
(FFT),
associated
were
demonstrated
to
play
crucial
role
in
immunomodulatory
protective
against
injury.
In
conclusion,
exhibits
significant
potential
as
an
immune
enhancer
natural
therapeutic
agent
for
alleviating
inflammatory
conditions.
Язык: Английский