Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15481 - 15481

Опубликована: Окт. 23, 2023

In the rapidly evolving field of Alzheimer's Disease (AD) research, intricate role Hydrogen Sulfide (H

Язык: Английский

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Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126541 - 126541

Опубликована: Ноя. 1, 2024

Язык: Английский

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Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics

Biomedicines, Год журнала: 2025, Номер 13(2), С. 446 - 446

Опубликована: Фев. 12, 2025

Background: Microplastics (MPs) are small plastic fragments with diameters less than 5 mm in size and prevalent everyday essentials consumables. Large global production has now led to a flooding of MPs our natural environment. Due their detrimental impacts on the planet's ecosystems potentially health, have emerged as significant public health concern. In this pilot study, we hypothesize that exposure will negatively affect gut microbiota composition function, which metabolic reprogramming plays an important role. Methods: Using vitro experiments, three bacterial strains (Escherichia coli MG1655, Nissle 1917, Lactobacillus rhamnosus) were selected investigate exposure. The individually cultured anaerobic chamber exposed 1 µm polystyrene at various concentrations (0, 10, 20, 50, 100, 500 µg/mL) culture medium. Results: reduced growth all dose-dependent manner. Liquid chromatography mass spectrometry (LC-MS)-based untargeted metabolomics revealed differences multiple pathways, such sulfur metabolism amino sugar nucleotide metabolism. addition, extracted from C57BL/6 mice, 16S rRNA sequencing results showed upregulation Lactobacillales reduction Erysipelotrichales due Furthermore, targeted corroborated alterations microbial tryptophan energy producing glycolysis/gluconeogenesis pentose phosphate pathway. Conclusions: These findings provide evidence causes comprehensive changes healthy microbiota, may also insights into mechanistic effects humans.

Язык: Английский

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Consumer risks and benefits: Macro and trace elements in muscle of dominant fish species from Vrana Lake, Croatia

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Quantitative study on reducing arsenic concentration in rice by sulfur fertilizer based on meta-analysis

Environmental Monitoring and Assessment, Год журнала: 2025, Номер 197(5)

Опубликована: Апрель 9, 2025

Язык: Английский

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Supersulfide donors and their therapeutic targets in inflammatory diseases

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Inflammation is one defense mechanism of the body that has multiple origins, ranging from physical agents to infectious including viruses and bacteria. The resolution inflammation emerged as a critical endogenous process protects host tissues prolonged or excessive inflammation, which can become chronic. Failure key pathological drives progression numerous inflammatory diseases. Owing various side effects currently available drugs control novel therapeutic prevent suppress are needed. Supersulfides highly reactive biologically potent molecules function antioxidants, redox regulators, modulators cell signaling. catenation state individual sulfur atoms endows supersulfides with unique biological activities. Great strides have recently been made in achieving molecular understanding these species, participate physiological pathways. This review mainly focuses on anti-inflammatory supersulfides. starts an overview supersulfide biology highlights roles both immune responses. donors used generate assessed research tools potential agents. Deeper cellular bases supersulfide-driven help guide development innovative strategies treat diseases associated

Язык: Английский

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The sewer advances: How to select eco-friendly pipe materials for environmental protection

The Science of The Total Environment, Год журнала: 2024, Номер 952, С. 175853 - 175853

Опубликована: Сен. 1, 2024

Язык: Английский

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Cellular targets of cytotoxic copper phenanthroline complexes: a multimodal imaging quantitative approach in single PC3 cells

Metallomics, Год журнала: 2024, Номер 16(11)

Опубликована: Ноя. 1, 2024

Metal complexes are emerging as promising alternatives to traditional platinum-based cancer treatments, offering reduced side effects. However, understanding their cellular uptake and distribution quantifying presence at the single cell level remains challenging. Advanced imaging techniques, including transmission electron microscopy, synchrotron radiation X-ray fluorescence, energetic ion beam-based nuclear microscopy (scanning particle-induced emission, elastic backscattering spectrometry), allow detailed high-resolution visualization of structure morphology, high sensitivity for elemental detection with quantification within cells, construction 3D models metal distribution, positioning them powerful tools assessing compartmentalization complexes. Three Cu(II) [Cu(phen)2(H2O)](NO3)2 (1), [Cu(Me2phen)2(NO3)]NO3 (2) [Cu(amphen)2(H2O)](NO3)2 (3), (phen = 1,10-phenanthroline, Me2phen 4,7-dimethyl-1,10-phen, amphen 5-amino-phen) were investigated Cu in PC3 prostate cells. All show significant regardless media concentration. concentrations cytoplasm nucleus similar between treatments. Complexes 1 3 concentrate region a vesicle-like pattern around nucleus, while 2 shows dispersed cytoplasmic large vesicles. The confirm that is not retained plasma membrane, complex targeting remaining cytoplasm. These results highlight importance correlating it structural changes understand relevance ligand mechanisms targeting, crucial development effective metal-based therapies.

Язык: Английский

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Astragalus polysaccharide alleviates asthma by modulating gut microbiota and serum metabolomics

Biomedical Reports, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 13, 2024

The aim of the present study was to examine effects Astragalus polysaccharide (APS) on gut microbiota and serum metabolites in asthmatic mice. For this purpose, a total 36 BALB/c female mice were selected randomly classified into following groups: i) normal control group sensitized with phosphate‑buffered saline; ii) asthma challenged ovalbumin (OVA); iii) OVA + APS (2.5 g/kg) treatment group; iv) (5.0 v) (10 vi) dexamethasone (2 mg/kg) group, 6 each group. used establish mouse model asthma. In intragastrically administered at various doses 1 h prior stimulation. airway hyperreactivity (AHR) measured, hematoxylin eosin staining employed evaluate pulmonary inflammatory infiltration. addition, 16S rRNA sequencing ultra‑performance liquid chromatography‑tandem mass spectrometry detect changes metabolites. results revealed that compared improved inflammation eosinophil infiltration mice, microbial imbalance mainly manifested as low abundance Bacteroidetes high Firmicutes, yielding an increased F/B ratio. high‑dose Firmicutes reduced, increased, which thereby decreased ratio corrected imbalance. Through blood metabolomics, 145 105 significantly differential detected medium‑ groups, respectively. Moreover, Kyoto Encyclopedia Genes Genomes pathway enrichment analysis demonstrated metabolic pathways medium‑dose included biosynthesis unsaturated fatty acids arginine. On other hand, enriched acids, pyrimidine metabolism. whole, demonstrates may regulate improve AHR

Язык: Английский

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Discovery of a Gut Bacterial Pathway for Ergothioneine Catabolism

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

Ergothioneine is a diet-derived micronutrient for humans. However, enzymes involved in the catabolism of ergothioneine human gut bacteria have not yet been identified. Herein, we characterize sulfidogenic pathway bacterial this micronutrient, which involves an unprecedented reductive desulfurization reaction catalyzed by members xanthine oxidoreductase family (XOR), class molybdenum-containing flavoproteins. Notably, first C-S bond cleavage known to be XORs. Evidence operation was gained through

Язык: Английский

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